Curriculum Vitae

Teresa Maria Caldeira Martins. É Investigador Auxiliar no Instituto Português de Oncologia Doutor Francisco Gentil - IPO Coimbra. Publicou 15 artigos em revistas especializadas e 16 trabalhos em actas de eventos. Possui 25 itens de produção técnica. Recebeu 2 prémios e/ou homenagens. Actua na área de Ciências Biológicas Nas suas actividades profissionais interagiu com 46 colaboradores em co-autorias de trabalhos científicos.
Endereço de acesso a este CV: http://www.degois.pt/visualizador/curriculum.jsp?key=0884946446272349

Nome completo Full name	Teresa Maria Caldeira Martins
Nome em citações bibliográficas Quoting name	Martins, Teresa Maria Caldeira
Categoria profissional Position	Investigador Auxiliar
Domínio científico de actuação Scientific domain	Ciências Naturais-Ciências Biológicas. Ciências Médicas-Ciências da Saúde.

Endereço profissional Professional address

Instituto Português de Oncologia Doutor Francisco Gentil - IPO Coimbra Av. Bissaya Barreto, 98 Coimbra 3000-075 Coimbra Portugal Apartado: 2005 Telefone: (+351)239400200Extensão: 2753 Fax: (+351)239484317 Correio electrónico: tmartins@ipocoimbra.min-saude.pt Homepage: www.ipocoimbra.min-saude.pt

Sexo Gender

Feminino»Female

1994-1998	Doutoramento Phd
Biomedicina (Imunologia). Universidade do Porto, Portugal.

1989-1993	Licenciatura Licentiate degree
Biologia (4 anos » years) . Universidade de Coimbra, Portugal.

2008-2008	Curso de curta duração Short course
Neuroimmunology. Universidade de Coimbra, Portugal.

2008-2008	Curso de curta duração Short course
Oncobiology. Universidade de Coimbra, Portugal.

2008-2008	Curso de curta duração Short course
Immunology. Universidade de Coimbra, Portugal.

2008-2008	Curso de curta duração Short course
Cell Death. Universidade de Coimbra, Portugal.

2007-2007	Outros Others
Workshop European Tissuebanking for Medical Research. Erasmus MC - Roterdam, Países Baixos.

1999-2003	Pós-Doutoramento Postdoctorate
Universidade do Porto, Portugal.

2000-2000	Outros Others
1st International Symposium on Laboratory Animals. Universidade de Coimbra, Portugal.

1999-1999	Curso de curta duração Short course
V Curso de Genética em Oncologia. Instituto Português de Oncologia Doutor Francisco Gentil - IPO Coimbra, Portugal.

1997-1997	Curso de curta duração Short course
Modulation of the Immune system. Universidade do Porto, Portugal.

1996-1996	Curso de curta duração Short course
Activation of the Immune System. Universidade do Porto, Portugal.

1995	Curso de curta duração Short course
Immune system: genes and development. Sociedade Portuguesa de Imunologia, Portugal.

1995	Curso de curta duração Short course
Basic Immunology. Fundação Calouste Gulbenkian, Portugal.

1994	Curso de curta duração Short course
Immunity to Intracellular Infections. Universidade do Porto, Portugal.

1993	Curso de curta duração Short course
II Curso de Genética em Oncologia. Instituto Português de Oncologia Doutor Francisco Gentil - IPO Coimbra, Portugal.

1992	Curso de curta duração Short course
Curso Teórico-Prático de Psiquiatria Genética. Hospitais da Universidade de Coimbra, Portugal.

1992	Curso de curta duração Short course
I Curso de Genética em Oncologia. Instituto Português de Oncologia Doutor Francisco Gentil - IPO Coimbra, Portugal.

Instituto Português de Oncologia Doutor Francisco Gentil - IPO Coimbra

Mai/2003-Actual

Investigador Auxiliar

Escola Universitária Vasco da Gama

Set/2002-Set/2005

Professor Auxiliar

Universidade do Porto

Jan/1994-Mai/2003

Outra Situação

Escola Superior de Enfermagem Cidade do Porto

Out/1999-Dez/1999

Professor Auxiliar

Instituto Português de Oncologia Doutor Francisco Gentil - IPO Coimbra

Mai/2003-Actual
Linhas de investigação»Research fields: Genética e Biologia do cancro Imunologia

Instituto Português de Oncologia Doutor Francisco Gentil - IPO Coimbra

Nov/2004-Actual

Instituto Português de Oncologia Doutor Francisco Gentil - IPO Coimbra

Out/2007-Actual
Vogal do Gabinete Coordenador da Investigação

Instituto Português de Oncologia Doutor Francisco Gentil - IPO Coimbra

Fev/2004-Actual
- Directora do Laboratório de Patologia Molecular

Instituto Português de Oncologia Doutor Francisco Gentil - IPO Coimbra

Ago/2004-Actual
Actividade de extensão realizada»Extension activity rendered:    - Ocupação Temporária de Jovens nas Férias - Ciência Viva

Outro Tipo de Participação Other kind of participation

Experimental autoimmune diabetes vaccination: role of Treg cells and pro-inflammatory cytokines

Referência do projecto»Project reference: POCTI/MGI/34175/99.

Lymphocyte antigen CD38 and immune homeostasis

Referência do projecto»Project reference: POCTI/BCI/34197/99.

Multifunctional ectoenzymes CD38 e CD157: role in solid tumours and lymphoid malignancies

Referência do projecto»Project reference: POCTI/BCI/44109/2002.

Risk-modifying genetic factors in BRCA172-associated breast and/or ovarian cancer

Referência do projecto»Project reference: POCTI/MGI/48912/2002.

Analysis of molecular alterations that are relevant for GIST carcinogenesis and treatment

Referência do projecto»Project reference: Novartis Oncology.

Compreende Understandig	Inglês (Bem), Espanhol (Bem), Francês (Razoavelmente).
Fala Speaking	Inglês (Bem), Espanhol (Bem), Francês (Razoavelmente).
Lê Reading	Inglês (Bem), Espanhol (Bem), Francês (Razoavelmente).
Escreve Writing	Inglês (Bem), Espanhol (Bem), Francês (Razoavelmente).

1998	1º Prémio Bial em Biomedicina, Bial.
2007	Bolsa Prof. E Limbert em Patologia da Tiróide, Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo /Genzyme.

2007- Actual	European Association for Cancer Research, Membro.
Nov/1994 - Actual	Portuguese Immunology Society (SPI), Membro.

Capítulos de livros publicados Published book chapters

1.	Martins, Teresa C. 2009. Mycobacteria and autoimmunity: the two sides of a coin.  In Cur. Topics on the Profiles of Host Immunological Response to Mycobacterial Infections, 183 - 217. . India: Research Signpost.

Artigos em revistas com arbitragem científica Papers in periodics with scientific refereeing

1.	Prazeres, Hugo J; Torres, Joana; Rodrigues, Fernando; Vinagre, João; Teixeira, Marta; Pastoriza, M C; Gomes, Daniela; Cameselle-Teijeiro, José; Vidal, Anxo; Martins, Teresa C; Simões, Manuel S; Soares, Paula. 2011. "Multiple levels of inactivation of LRP1B, a modulator of MMP2 in the extracellular environment of human cancer cells", Oncogene 30, 11: 1302 - 1317.

2.	Nobre, Rui J; Cruz, Eugénia; Real, Odete; Almeida, Luís P; Martins, Teresa C. 2010. "Characterization of the Common and Rare Human Papillomaviruses in Portuguese Women by Polymerase Chain Reaction, Restriction Fragment Length Polymorphism and Sequencing", J. Med. Virol, 82: 1024 - 1032.

3.	Prazeres, Hugo J; Rodrigues, Fernando; Naidenov, Plamen; Figueiredo, Paulo; Soares, Paula; Lacerda, Manuela; Campos, Beatriz; Martins, Teresa C. 2008. "Loss of Heterozygosity at 19p13.2 and 2q21 in Tumours from Familial Clusters of Non-Medullary Thyroid Carcinoma", Familial Cancer , 7: 141 - 149.

4.	Nobre, Rui J; Almeida, Luís P; Martins, Teresa C. 2008. "Complete genotyping of mucosal human papillomavirus using a restriction fragment length polymorphism analysis and an original typing algorithm", J. Clin. Virol, 42: 13 - 21.

5.	Viegas, Marta S; Seco, F; Martins, Teresa C; Carmo, Anália. 2007. "An improved and cost effective methodology for the reduction of autofluorescence in direct immunofluorescence studies on formalin-fixed paraffin-embedded tissues", Eur. J. Histochemistry , 51: 59 - 66.

6.	Viegas, Marta S; Carmo, Anália; Seco, F; Lacerda, Manuela; Martins, Teresa C. 2007. "CD38 plays a role in effective containment of mycobacteria within granulomata and polarization of Th1 immune responses against Mycobacterium avium", Microbes Infect, 9: 847 - 854.

7.	Martins, Teresa C; Prazeres, Hugo J; Rodrigues, Fernando; Figueiredo, Paulo; Naidenov, Plamen; Soares, Paula; Bugalho, Maria J; Faro, Carlos; Campos, Beatriz; Lacerda, Manuela. 2006. "Recurrence of the Cys611Tyr mutation and a novel Arg886Trp substitution in the RET proto-oncogene in multiple endocrine neoplasia type 2 families and sporadic medullary thyroid carcinoma cases originating from the central region of Portugal", Clin. Endocrinol 64, -: 659 - 666.

8.	Martins, Teresa C. 2005. "Buba – adapting to a life on three legs", FAB Journal 43, -: 56 - 57.

9.	Martins, Teresa C; Águas, Artur P. 1999. "Mechanisms of M. avium-induced resistance against IDDM in non-obese diabetic (NOD) mice: role of Fas and Th1 cells", Clin. Exp. Immunol 115, -: 248 - 254.

10.	Martins, Teresa C; Águas, Artur P. 1999. "NOD mice are resistant to depletion of thymic cells caused by acute stress or infection", Autoimmunity 29, -: 273 - 280.

11.	Martins, Teresa C; Águas, Artur P. 1999. "A role for CD45RBloCD38 T cells and co-stimulatory pathways of T cell activation in protection of NOD mice from diabetes", Immunology 96, -: 600 - 605.

12.	Martins, Teresa C; Águas, Artur P. 1998. "Involvement of c-myc in the resistance of non-obese diabetic (NOD) to glucocorticoid-induced apoptosis", Immunology 95, 3: 377 - 382.

13.	Martins, Teresa C; Águas, Artur P. 1996. "Changes in B and T lymphocytes associated with mycobacteria-induced protection of NOD mice from diabetes", J. Autoimmunity 9, -: 501 - 507.

14.	Martins, Teresa C; Águas, Artur P. 1995. "Stress modulates acute inflammation triggered by mycobacteria in autoimmunity-prone and normal mice", Inflamm. Res.  44, -: 393 - 399.

Trabalhos completos/resumidos em eventos com arbitragem científica Papers in conference proceedings with scientific refereeing

1.	Martins, Teresa C; Viegas, Marta S; Lund, Frances; Thankappan, A. 2010. "CD38 is required for dendritic cell priming of Th1 responses to Mycobacterium avium infection", Trabalho apresentado em 14th International Congress of Immunology., In International Immunol , Kobe.

2.	Martins, Teresa C; Viegas, Marta S. 2009. "Absence of CD38 compromises leukocyte recruitment and macrophage activation during responses to mycobacteria", Trabalho apresentado em III International Congress of Molecular Medicine, In IUBMB Life, Istanbul.

3.	Martins, Teresa C; Gonçalves, Vera; Pais, Rosete. 2009. "Polymorphisms in DEFA1, 2 and 3 and DEFA5 are associated with increased risk for HPV infection and development of cervical cancer.", Trabalho apresentado em III International Congress of Molecular Medicine, In IUBMB Life , Istanbul.

4.	Gonçalves, Vera; Prazeres, Hugo J; Lacerda, Manuela; Martins, Teresa C. 2009. "Genetic susceptibility factors for breast cancer in the Portuguese population: AIB1, PPARGC1A, CYP1A1 and DSS1", Trabalho apresentado em III International Congress of Molecular Medicine, In IUBMB Life , Istanbul.

5.	Martins, Teresa C; Gonçalves, Vera; Pais, Rosete; Teles, Vera. 2009. "Polymorphisms in DEFA1, 2, 3, DEFA5 and TLR7: association with susceptibility to HPV infection and persistence and development of cervical cancer", Trabalho apresentado em 2nd European Congress of Immunology, In Eur. J. Immunol, Berlin.

6.	Martins, Teresa C; Viegas, Marta S; Lun, Frances; Cooper, Andrea; Pearl, John. 2009. "CD38 plays a role in the development of productive immune responses against Mycobacterium tuberculosis", Trabalho apresentado em 2nd European Congress of Immunology, In Eur J Immunol, Berlin.

7.	Lacerda, Manuela; Gonçalves, Vera; Monteiro, Maria M; Madeira, Andreia; Martins, Teresa C. 2008. "Loss of expression of Claspin in tumour cells may be involved in breast carcinogenesis", Trabalho apresentado em 20th Meeting of the European Association for Cancer Research – EACR20, In European J. Cancer, Lyon, France.

8.	Viegas, Marta S; Carmo, Anália; Martins, Teresa C. 2006. "Absence of CD38 accelerates development of a lupus-like disease in C57Bl.6-lpr/lpr mice", Trabalho apresentado em The CD38 ectoenzyme family: advances in basic science and clinical practice, In Molecular Medicine, Turin, Itália.

9.	Viegas, Marta S; Martins, Teresa C. 2004. "Absence of CD38 accelerates development of systemic autoimmune disease", Trabalho apresentado em 4th International Congress on Autoimmunity, In Autoimmun. Rev., Budapeste.

10.	Ferreira, Patrícia; Martins, Teresa C. 2004. "Prevention of diabetes in NOD mice: role for TGFbeta-CD40 cross-talk on B cells.", Trabalho apresentado em 4th International Congress on Autoimmunity, In Autoimmun. Rev., Budapeste.

11.	Rodrigues, Monica I; Águas, Artur P; Martins, Teresa C. 2003. "Deficient activation of NOD T cells: reduced tyrosine phosphorylation and c-myc expression", Trabalho apresentado em 15th European Immunology Meeting, In Immunol. Lett., Rhodes.

12.	Viegas, Marta S; Águas, Artur P; Martins, Teresa C. 2003. "CD38: a role in immunity to mycobacterial infection? ", Trabalho apresentado em 15th European Immunology Meeting, In Immunol. Lett, Rhodes.

13.	Ferreira, Patrícia; Águas, Artur P; Martins, Teresa C. 2003. "Prevention of autoimmune diabetes of NOD mice by mycobacterial infection: role for myeloid and lymphoid dendritic cells", Trabalho apresentado em 15th European Immunology Meeting, In Immunol. Letts., Rhodes.

14.	Martins, Teresa C; Águas, Artur P. 2003. "Vaccination of NOD mice against diabetes by Mycobacterium avium infection: rescue of high activation threshold T cells from hyporresponsiveness.", Trabalho apresentado em 15th European Immunology Meeting, In Immunol. Letts, Rhodes.

15.	Martins, Teresa C; Ferreira, Patrícia; Huygen, Kris; Águas, Artur P. 2003. "DNA vaccination of NOD mice against diabetes: role for IgG B cells and CD28-CD8 T cells?", Trabalho apresentado em 15th European Immunology Meeting, In Immunol. Letts., Rhodes.

16.	Martins, Teresa C; Águas, Artur P. 2000. "Diabetes vaccination: role of Treg cells in mycobacteria -induced resistance against diabetes in NOD mice ", Trabalho apresentado em 14th European Immunology Meeting, In Immunol. Lett. , Poznan.

Apresentação oral de trabalho Oral work presentation

1.	Viegas, Marta S; Carmo, Anália; Martins, Teresa C. Absence of CD38 accelerates development of a lupus-like disease in C57Bl.6-lpr/lpr mice.,The CD38 ectoenzyme family: advances in basic science and clinical practice.,Turin,2006 (Comunicação).

2.

Prazeres, Hugo J; Gonçalves, Vera; Viegas, Marta S; Leite, Ana M; Santos, AH; Lima, Margarida; Martins, Teresa C. Lymphocyte differentiation marker CD38 and immune homeostasis: PvuII polymorphisms and development of B-chronic lymphocytic leukaemia,2nd ESF – Functional Genomics Conference,Oslo,2005 (Poster).

3.	Viegas, Marta S; Martins, Teresa C. Relevance of CD38 on immune homeostasis: knocking out of CD38 accelerates development of autoimmune disease with kidney involvement,2nd ESF – Functional Genomics Conference,Oslo,2005 (Poster).

4.	Prazeres, Hugo J; Martins, Teresa C. Whole genomic allelic imbalance analysis in familial non-medullary thyroid cancer. ,2nd ESF – Functional Genomics Conference,Oslo,2005 (Poster).

5.	Martins, Teresa C; Prazeres, Hugo J; Cruz, Eugénia. CD157 polymorphisms on exon 3 are associated with development of cervical cancer in HPV-infected women,21st International Conference and Clinical Workshop on Papillomavirus,Cidade do México,2004 (Poster).

6.	Prazeres, Hugo J; Leite, Ana M; Martins, Teresa C. CD38 PvuII polymorphisms: over-representation of the AA genotype in B-CLL patients,XII Meeting of the European Association for Haematopathology.,Saloniki,2004 (Poster).

7.	Viegas, Marta S; Martins, Teresa C. Absence of CD38 accelerates development of systemic autoimmune disease. ,4th International Congress on Autoimmunity,Budapest,2004 (Poster).

8.	Ferreira, Patrícia; Martins, Teresa C. Prevention of diabetes in NOD mice: role for TGFbeta-CD40 cross-talk on B cells,4th International Congress on Autoimmunity,Budapest,2004 (Poster).

9.	Rodrigues, Mónica I; Águas, Artur P; Martins, Teresa C. Deficient activation of NOD T cells: reduced tyrosine phosphorylation and c-myc expression,15th European Immunology Meeting,Rhodes,2003 (Poster).

10.	Viegas, Marta S; Águas, Artur P; Martins, Teresa C. CD38: a role in immunity to mycobacterial infection? ,15th International Immunology Congress,Rhodes,2003 (Poster).

11.	Ferreira, Patrícia; Águas, Artur P; Martins, Teresa C. Prevention of autoimmune diabetes of NOD mice by mycobacterial infection: role for myeloid and lymphoid dendritic cells,15th European Immunology Meeting,Rhodes,2003 (Poster).

12.	Martins, Teresa C; Águas, Artur P. Vaccination of NOD mice against diabetes by Mycobacterium avium infection: rescue of high activation threshold T cells from hyporresponsiveness,15th European Immunology Meeting,Rhodes,2003 (Poster).

13.	Martins, Teresa C; Ferreira, Patrícia; Huygen, Kris; Águas, Artur P. DNA vaccination of NOD mice against diabetes: role for IgG B cells and CD28-CD8 T cells?,15th European Immunology Meeting,Rhodes,2003 (Poster).

14.	Martins, Teresa C; Águas, Artur P. Effects of TGFbeta on B cells of vaccinated NOD mice are dependent on costimulation via CD40: role for inhibitory Smads?,6th International Symposium on “Predictive Oncology and Intervention Strategies”,Paris,2002 (Poster).

15.	Martins, Teresa C; Águas, Artur P. Glucocorticoid resistance of NOD mice lymphocytes: defective suppression of c-myc transcription results from delayed dissociation of glucocorticoid receptor complex.,3rd International Congress on Signal Transduction,Dubrovnik,2002 (Poster).

16.	Viegas, Marta S; Águas, Artur P; Martins, Teresa C. Signalling cascade of CD38 in lupus-prone and normal mice: differences in c-myc expression and protein tyrosine phosphorylation,3rd International Congress on Signal Transduction,Dubrovnik,2002 (Poster).

17.	Martins, Teresa C; Águas, Artur P. Regulation by TGFbeta of CD40 expression on B cells of NOD mice vaccinated against diabetes,10th International Congress of Immunology,Stockolm,2001 (Poster).

18.	Martins, Teresa C; Águas, Artur P. In vitro response to SA-5K of immune cells from mycobacteria-immunised mice.,3rd BIOMED Meeting,Pisa,2000 (Comunicação).

19.	Martins, Teresa C; Águas, Artur P. Diabetes vaccination: role of Treg cells in mycobacteria -induced resistance against diabetes in NOD mice. ,14th European Immunology Meeting,Poznan,2000 (Comunicação).

20.	Martins, Teresa C; Águas, Artur P. Immune response to SA-5K,2nd BIOMED Meeting,Pisa,1999 (Comunicação).

21.	Martins, Teresa C; Águas, Artur P. Infection and apoptosis in NOD mice.,13th European Immunology Meeting,Amsterdam,1997 (Poster).

22.	Martins, Teresa C; Águas, Artur P. Infection and/or stress modify apoptosis frequency and lymphocyte subpopulations in the thymus of mice,14th International Congress: The Phagocyte - molecular and clinical aspects,Verona, Itália,1996 (Poster).

23.	Martins, Teresa C; Águas, Artur P. Mycobacteria-induced protection of NOD mice from diabetes is associated with enhancement in CD4+ T cells and B220+ B cells,2nd Symposium on the Pathogenesis and Immunotherapy of Autoimmune Diseases.,Milano,1996 (Poster).

24.	Martins, Teresa C; Águas, Artur P. Acute stress changes the inflammatory response of lupus-prone NZB/W mice.,9th International Congress of Immunology,San Francisco,1995 (Poster).

Organização de evento Event organization

1.	Martins, Teresa C; Lopes, Maria C. Oncobiology,2007 (Outro / Organização).

Produção científica Scientific production

Produção técnica Technical production

Total

Produção científica Scientific production

31

Livros e capítulos Books and book chapters

1

Capítulos de livros publicados Published book chapters

1

Artigos científicos em revistas Papers in periodics

14

Com arbitragem científica With scientific refereeing

14

Trabalhos em eventos Papers in conference proceedings

16

Com arbitragem científica With scientific refereeing

16

Total

Produção técnica Technical production

25

Outros tipos de produção técnica Other technical production

25

Luis Fernando Morgado Pereira de Almeida