Ana Luísa Colaço Cardoso
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Data da última atualização
»Last update
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09/09/2015 |
Dados pessoais (Personal data)
Nome completo
Full name |
Ana Luísa Colaço Cardoso |
Nome em citações bibliográficas
Quoting name |
Cardoso, Ana Luísa Colaço |
Domínio científico de atuação
Scientific domain |
Ciências Naturais-Ciências Biológicas. Ciências Médicas-Biotecnologia Médica.
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Endereço profissional
Professional address |
Universidade de Coimbra -Centro de Neurociências e Biologia Celular Centro de Neurociências e Biologia Celular 3004-517 Águeda Portugal Correio electrónico: alcardoso@ci.uc.pt |
Sexo
Gender |
Feminino»Female |
Graus Académicos
(Academic Degrees)
2005-2008 |
Doutoramento Phd |
Tecnologia Bioquímica
(4 anos » years)
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Universidade de Coimbra,
Portugal.
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1999-2004 |
Licenciatura Licentiate degree |
Bioquímica
(4 anos » years)
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Universidade de Coimbra,
Portugal.
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Formação complementar ( studies)
2010-2010 |
Curso de curta duração Short course |
Formação Pedagógica Inicial de Formadores.
Tecla Centro,
Portugal.
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2009-2009 |
Curso de curta duração Short course |
Curso de Experimentação Animal - Grau C.
Universidade de Coimbra -Centro de Neurociências e Biologia Celular,
Portugal.
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Vínculos profissionais
(Professional Positions)
Fev/2008-Actual |
Outra Situação |
Línguas (Languages)
Compreende Understandig |
Inglês (Bem), Francês (Bem), Alemão (Razoavelmente), Português (Bem). |
Fala Speaking |
Inglês (Bem), Francês (Razoavelmente), Alemão (Pouco), Português (Bem). |
Lê Reading |
Inglês (Bem), Francês (Bem), Alemão (Pouco), Português (Bem). |
Escreve Writing |
Inglês (Bem), Francês (Pouco), Alemão (Pouco), Português (Bem). |
Prémios e títulos (Awards Prizes, and Honours)
2004 |
Bolsa de Mérito,
Universidade de Coimbra.
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Membro de Associações Profissionais/Científicas (Professional/Scientific Association membership)
Jan/2004 - Actual |
Sociedade Portuguesa de Bioquímica, Membro.
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Produção científica, técnica e artística/cultural
(Scientific, technical and artistical/cultural
production)
Capítulos de livros publicados Published book chapters |
1. |
Faneca, Henrique; Cardoso, Ana L. C; Trabulo, Sara M; Duarte, Sónia P; Pedroso de L. M. C. 2012. Cationic liposome-based systems for nucleic acid delivery: from the formulation development to therapeutic applications. In Drug delivery systems: Advanced technologies potentially applicable in personalized treatments, ed. Coelho, Jorge, 0 - 0. . New York: Springer. |
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2. |
Cardoso, Ana L. C; Trabulo, Sara M; Almeida, Luís P; Pedroso de L. M. C. 2012. Interaction of nucleic acids with biological membranes: activation of inflammatory mechanisms. In A Toxicological / Pharmacological Approach to the Chemico-Biological Interactions at the Membrane Level, ed. Jurado, Amália, 0 - 0. . ...: Translational Research Network. |
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3. |
Cardoso, Ana L. C; Trabulo, Sara M; Duarte, Sónia P; Costa, Pedro; Almeida, Luís P; Pedroso de L. M. C. 2010. Gene silencing as a promising strategy to target CNS and neurological disorders. In Gene Silencing: Theory, Techniques and Applications, 0 - 0. . New York: Nova Science Publishers.
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Artigos em revistas com arbitragem científica Papers in periodics with scientific refereeing |
1. |
Trabulo, Sara M; Cardoso, Ana L. C; Cardoso, A. M; Jurado, Amália S; Pedroso de L. M. C. 2012. "Cell-penetrating Peptide-based systems for nucleic Acid delivery: a biological and biophysical approach", Methods Enzymol, 509: 277 - 300.
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2. |
Trabulo, S.; Cardoso, A. M; Santos-Ferreira, T.; Cardoso, A. L; Simo~es, S.; Pedroso de L. M. C. 2011. "Survivin Silencing as a Promising Strategy To Enhance the Sensitivity of Cancer Cells to Chemotherapeutic Agents", Molecular Pharmaceutics 8, 4: 1120 - 1131.
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3. |
Cardoso, Ana L. C; Simões, Sérgio; Almeida, Luís P; Culmsee, Carsten; Wagner, Ernst; Pedroso de L. M. C. 2010. "Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage", Journal of Controlled Release, 142: 392 - 403. |
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4. |
Trabulo, Sara; Cardoso, Ana L; Mano, Miguel; de Lima, M. C. P. 2010. "Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems", Pharmaceuticals 3, 4: 961 - 993.
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5. |
Cardoso, Ana L. C; Simões, Sérgio; Almeida, Luís P; Pedroso de L. M. C; Wagner, Ernst; Culmsee, Carsten. 2008. "Tf-lipoplexes for neuronal siRNA delivery in vitro and in vivo: A promising system to mediate gene silencing in the CNS", Journal of Controlled Release, 132: 113 - 123. |
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6. |
Trabulo, Sara M; Cardoso, Ana L. C. 2008. "S413-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA", Journal of Gene Medicine, 10: 1210 - 1222. |
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7. |
Cardoso, Ana L. C; Simões, Sérgio; Almeida, Luís P; Culmsee, Carsten; Wagner, Ernst; Pedroso de L. M. C. 2007. "siRNA delivery by a transferrin-associated lipid-based vector: a non-viral strategy to mediate gene silencing", Journal of Gene Medicine, 9: 170 - 193. |
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8. |
Pedroso de L. M. C; Cardoso, Ana L. C. 2005. "Liposomal and Viral Vectors for Gene Therapy of the Central Nervous System", Current Drug Targets – CNC & Neurological Disorders 4, 4: 453 - 465. |
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Artigos em revistas sem arbitragem científica Papers in periodics without scientific refereeing |
1. |
Cardoso, A.M.; Morais, C.M.; Cruz, A.R.; Cardoso, A.L.C.; Silva, S.G.; Do Vale, M; Marques, E.F.; Pedroso De L. M; Jurado, A.S.. 2015. "Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression", Molecular Pharmaceutics 12, 3: 716 - 730. |
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2. |
Costa, P.M.; Cardoso, A.L.C.; Mano, M.; de Lima, M. 2015. "MicroRNAs in glioblastoma: Role in pathogenesis and opportunities for targeted therapies", CNS and Neurological Disorders - Drug Targets 14, 2: 222 - 238. |
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3. |
Cardoso, A.M.; Calejo, M.T.; Morais, C.M.; Cardoso, A.L.C.; Cruz, R.; Zhu, K.; Pedroso De L. M; Jurado, A.S.; Nyström, B.. 2014. "Application of thermoresponsive PNIPAAM-b-PAMPTMA diblock copolymers in siRNA delivery", Molecular Pharmaceutics 11, 3: 819 - 827. |
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4. |
Guedes, J. R; Custodia, C. M; Silva, R. J; de Almeida, L. P; Pedroso de L. M. C; Cardoso, A. L. 2014. "Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model", Human Molecular Genetics 23, 23: 6286 - 63.
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5. |
Trabulo, S.; Cardoso, A.L.C.; Cardoso, A.M.S.; Morais, C.M.; Jurado, A.S.; Pedroso de L. M. 2013. "Cell-penetrating peptides as nucleic acid delivery systems: From biophysics to biological applications", Current Pharmaceutical Design 19, 16: 2895 - 29. |
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6. |
Cardoso, A.M.; Trabulo, S.; Cardoso, A.L.C.; Maia, S.; Gomes, P.; Jurado, A.S.; Pedroso De L. M. 2013. "Comparison of the efficiency of complexes based on S413-PV cell-penetrating peptides in plasmid DNA and siRNA delivery", Molecular Pharmaceutics 10, 7: 2653 - 26. |
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7. |
Costa, P.M.; Cardoso, A.L.C.; Nóbrega, C.; Pereira de a. L; Bruce, J.N.; Canoll, P.; Pedroso de L. M. 2013. "MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma", Human Molecular Genetics 22, 5: 904 - 918. |
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8. |
Calejo, M.T.; Cardoso, A.M.S.; Kjøniksen, A.-L.; Zhu, K.; Morais, C.M.; Sande, S.A.; Cardoso, A.L.C.; Lima, M.C.P.D.; Jurado, A.S.; Nyström, B.. 2013. "Temperature-responsive cationic block copolymers as nanocarriers for gene delivery", International Journal of Pharmaceutics 448, 1: 105 - 114. |
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9. |
Cardoso, Ana L; Guedes, Joana R; Pereira de A. L; Pedroso de L. M. C. 2012. "miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production", Immunology 135, 1: 73 - 88.
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10. |
Cardoso, Ana M; Trabulo, Sara; Cardoso, Ana L; Lorents, Annely; Morais, Catarina M; Gomes, Paula; Nunes, Cláudia; Lúcio, Marlene; Reis, Salette; Padari, Kärt; Pooga, Margus; Pedroso de L. M. C; Jurado, Amália S. 2012. "S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes:
Implications for cell internalization", Biochimica et Biophysica Acta (BBA) - Biomembranes 1818, 3: 877 - 888.
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11. |
Costa, P.M.; Cardoso, A.L.C.; Pereira de a. L; Bruce, J.N.; Canoll, P.; Pedroso de l. M. 2012. "PDGF-B-mediated downregulation of miR-21: New insights into PDGF signaling in glioblastoma", Human Molecular Genetics 21, 23: 5118 - 51. |
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12. |
Cardoso, Ana M; Trabulo, Sara M; Cardoso, Ana L. C; Lorents, Annely; Morais, Catarina M; Gomes, Paula; Nunes, Cláudia; Lúcio, Marlene; Reis, Salette; Padari, Kärt; Pooga, Margus; Pedroso de L. M. C; Jurado, Amália S. 2011. "S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes:
Implications for cell internalization", Biochimica et Biophysica Acta (BBA) - Biomembranes, 0: 0 - 0.
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13. |
Trabulo, S.; Cardoso, A.M.; Santos-Ferreira, T.; Cardoso, A.L.C.; Simões, S.; Pedroso De L. M. 2011. "Survivin silencing as a promising strategy to enhance the sensitivity of cancer cells to chemotherapeutic agents", Molecular Pharmaceutics 8, 4: 1120 - 11. |
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14. |
Trabulo, Sara M; Cardoso, Ana L. C; Pedroso de L. M. C. 2010. "Cell penetrating peptides: Mechanisms of cellular uptake and generation of nucleic acid delivery systems", Pharmaceuticals 3, 4: 961 - 993. |
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15. |
Trabulo, S.; Cardoso, A.L.C.; Mano, M.; de Lima, M. 2010. "Cell-penetrating peptides-mechanisms of cellular uptake and generation of delivery systems", Pharmaceuticals 3, 4: 961 - 993. |
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16. |
Cardoso, A.L.C.; Costa, P.; de Almeida, L; Simões, S.; Plesnila, N.; Culmsee, C.; Wagner, E.; Pedroso de L. M. 2010. "Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo", Journal of Controlled Release 142, 3: 392 - 403. |
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17. |
Cardoso, Ana L. C; Trabulo, Sara M; Pedroso de L. M. C. 2009. "Targeted lipoplexes for siRNA delivery", Methods in Enzimology, 465: 267 - 287. |
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18. |
Cardoso, A. M; Trabulo, S.; Moreira, J.N.; Düzgünes, N.; de Lima, M. 2009. "Chapter 14 Targeted Lipoplexes for siRNA Delivery", Methods in Enzymology 465, C: 267 - 287. |
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19. |
Cardoso, A.L.C.; Simões, S.; de Almeida, L; Plesnila, N.; Pedroso de L. M; Wagner, E.; Culmsee, C.. 2008. "Tf-lipoplexes for neuronal siRNA delivery: A promising system to mediate gene silencing in the CNS", Journal of Controlled Release 132, 2: 113 - 123. |
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20. |
Cardoso, A.L.C.; Simões, S.; de Almeida, L; Pelisek, J.; Culmsee, C.; Wagner, E.; Pedroso de L. M. 2007. "siRNA delivery by a transferrin-associated lipid-based vector: A non-viral strategy to mediate gene silencing", Journal of Gene Medicine 9, 3: 170 - 183. |
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21. |
Girão da C. M. T; Cardoso, Ana L. C. 2005. "Cationic Liposome-mediated In Vivo Gene Transfer to the CNS", Gene Therapy 12, 16: 1242 - 1252. |
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22. |
Pedroso de L. M; Girão da C. M; Cardoso, A.L.C.; Simões, S.; Pereira de A. L. 2005. "Liposomal and viral vectors for gene therapy of the central nervous system", Current Drug Targets: CNS and Neurological Disorders 4, 4: 453 - 465. |
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23. |
Girão da C. M; Cardoso, A.L.C.; de Almeida, L; Simões, S.; Pedroso de L. M. 2005. "Tf-lipoplex-mediated NGF gene transfer to the CNS: Neuronal protection and recovery in an excitotoxic model of brain injury", Gene Therapy 12, 16: 1242 - 12. |
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Apresentação oral de trabalho Oral work presentation |
1. |
Cardoso, Ana M; Trabulo, Sara M; Cardoso, Ana L. C; Maia, S; Gomes, P; Jurado, Amália S; Pedroso de L. M. C. Efficient siRNA delivery mediated by S413-PV cell penetrating peptide-based systems: a comparative study,13th Naples Workshop on Bioactive Peptides - Conformation and Activity in Peptides: Relationships and Interactions,Nápoles,2012 (Comunicação). |
2. |
Cardoso, Ana L. C; Guedes, Joana R; Almeida, Luís P; Pedroso de L. M. C. Deregulation of immune-related miRNAs in Alzheimer’s disease,10th European meeting of glial cells in health and disease,Prague,2011 (Poster). |
3. |
Costa, Pedro; Cardoso, Ana L. C; Cannol, Peter; Bruce, J.; Almeida, Luís P; Pedroso de L. M. C. PDGF-mediated modulation of miRNAs in glioblastoma multiforme: a new paradigm in miRNA regulation in brain tumors,Portuguese Genetic Conferences,Coimbra,2011 (Comunicação). |
4. |
Costa, Pedro; Cardoso, Ana L. C; Cannol, Peter; Bruce, J.; Almeida, Luís P; Pedroso de L. M. C. PDGF-mediated modulation of miR-21 and miR-128 in glioblstoma multiforme: new insights into miRNA regulation in brain tumors,Porto cancer Meeting,Porto,2011 (Poster). |
5. |
Costa, Pedro; Cardoso, Ana L. C; Cannol, Peter; Bruce, J.; Almeida, Luís P; Pedroso de L. M. C. Modulation of miRNAs in glioblastoma multiforme: a new paradigm in PDGF regulation of brain tumors,International Symposium: ncRNAs and human disease,Copenhagen,2011 (Poster). |
6. |
Costa, Pedro; Cardoso, Ana L. C; Pedroso de L. M. C. miR-21 upregulation and miR-128a downregulation in human glioblastomas,RNAi & miRNA World Congress,Boston,2010 (Poster). |
7. |
Cardoso, Ana L. C. Non-viral gene therapy to the CNS: DNA and siRNA delivery for the treatment of excitotoxic injury,BEB Ph.D program,Coimbra,2010 (Comunicação). |
8. |
Cardoso, Ana L. C; Almeida, Luís P; Duarte, Carlos B; Pedroso de L. M. C. Modulation of Microglia Immune Response by miR-155,RNAi World Congress 2010,Boston,2010 (Poster). |
9. |
Cardoso, Ana L. C. Lipoplex-mediated siRNA and DNA delivery to the CNS,Nanomedicine Advanced Course,Lisboa,2009 (Comunicação). |
10. |
Cardoso, Ana L. C. Quando o gene se transforma em Medicamento,Brain Awareness Week,Coimbra,2009 (Comunicação). |
11. |
Trabulo, Sara M; Cardoso, Ana L. C. S413-PV cell penetrating peptide associated with different cargos: assessment of delivery efficiency and internalization mechanisms,30th European Peptide Symposium (30EPS) - Cell-Penetrating Peptides Satellite Symposium,Helsinki,2008 (Comunicação). |
12. |
Cardoso, Ana L. C. Tf-lipoplex-mediated c-Jun knockdown results in neuroprotection following excitotoxic injury in the mouse brain,European Society of Gene and Cell Therapy Meeting,Brugges,2008 (Poster). |
13. |
Cardoso, Ana L. C. siRNA delivery to the CNS: Tf-lipolex-mediated gene silencing in vitro and in vivo,2nd International Symposium on Cellular Delivery of Therapeutic Macromolecules,Cardiff,2008 (Poster). |
14. |
Trabulo, Sara M; Cardoso, Ana L. C; Pedroso de L. M. C. Association S413-PV cell penetrating peptide with cationic liposomes: a synergistic effect on the intracellular delivery of
plasmid DNA,30th European Peptide Symposium (30EPS) ,Helsinki,2008 (Poster). |
15. |
Duarte, Sónia P; Cardoso, Ana L. C; Pedroso de L. M. C. Folate-associated cationic liposomes as a promising system for tumor-targeted gene delivery, European Society of Gene and Cell Therapy Meeting,Brugges,2008 (Poster). |
16. |
Trabulo, Sara M; Cardoso, Ana L. C; Pedroso de L. M. C. S413-PV cell penetrating peptide-based strategies for the intracellular delivery of nucleic acids,Cell Penetrating Peptides,Telford,2007 (Poster). |
17. |
Cardoso, Ana L. C; Pedroso de L. M. C. Gene silencing in the CNS: Tf-lipoplexes for neuronal siRNA delivery in vitro and in vivo,3rd Congress of The Oligonucleotides Therapeutic Society,Berlin,2007 (Poster). |
18. |
Cardoso, Ana L. C. siRNA delivery to the Central Nervous System: Tf-lipoplex-mediated gene silencing in vitro and in vivo,V Annual Meeting of the Center for Neuroscience and Cell Biology,Coimbra,2007 (Comunicação). |
19. |
Trabulo, Sara M; Cardoso, Ana L. C; Pedroso de L. M. C. A novel approach for the intracellular delivery of nucleic acids based on the S413-PV cell penetrating peptide,2nd Workshop on Biophysics of Membrane-active Peptides,Lisboa,2007 (Poster). |
20. |
Trabulo, Sara M; Cardoso, Ana L. C; Pedroso de L. M. C. Enhancement of the intracellular delivery of siRNA and plasmid DNA using S4(13)-PV cell penetrating peptide-based systems,2nd Intracellular Delivery of Therapeutic Molecules – From Concept to Application,Grenoble,2007 (Poster). |
21. |
Cardoso, Ana L. C. Gene silencing in the CNS: Tf-lipoplexes for neuronal siRNA delivery in vitro and in vivo,Congresso Nacional de Bioquímica,Aveiro,2006 (Comunicação). |
22. |
Cardoso, Ana L. C; Pedroso de L. M. C. Development of transferrin–associated lipoplexes for siRNA delivery: a new strategy to mediate gene silencing in the CNS,5th Forum of European Neuroscience,Vienna,2006 (Poster). |
23. |
Cardoso, Ana L. C. siRNA delivery by Tf-associated lipoplexes: a novel non-viral strategy to mediate gene silencing in neurons,Congress of the German Pharmacological Society,Mainz,2006 (Comunicação). |
24. |
Cardoso, Ana L. C; Pedroso de L. M. C. siRNA delivery by a transferrin associated lipid-based vector: a new non-viral strategy to mediate gene silencing,13Th Cogress of the European Society of Gene Therapy,Prague,2005 (Poster). |
25. |
Cardoso, Ana L. C; Pedroso de L. M. C. Development of lipid-based vectors for siRNA delivery to the CNS: new strategies for the treatment of acute brain ischemia.,FENS Summer School,Ofir,2005 (Poster). |
26. |
Girão da C. M. T; Cardoso, Ana L. C. Cationic Liposome-mediated In Vivo Gene Transfer to the CNS,Congresso Nacional de Bioquímica,Vilamoura,2005 (Comunicação). |
Dados Complementares (Additional data)
Dissertação de Mestrado Master degree dissertation |
1. |
Joana Ribeiro Guedes, Evaluation of miR-155 and miR-125b regulatory effect on astrocyte-mediated immune response, 2011. Dissertação (Bioquímica) - Universidade de Coimbra (Orientador). |
Trabalho de conclusão de curso de Bacharelato/Licenciatura Bachelor/Licenciate degree conclusion work |
1. |
Joana Ribeiro Guedes, Alzheimer's disease: Evaluation of miR-155 regulatory effect in microglial activation and astrocyte proliferation, 2010. Trabalho de Conclusão de Curso (Licenciatura em Bioquímica) - Universidade de Coimbra (Orientador). |
1. |
Ricardo silva, miRNA contribution to the pathology of Alzheimer’s Disease, 2012. Trabalho de Conclusão de Curso (Licenciatura em Bioquímica) - Universidade de Coimbra (Orientador). |
2. |
Carlos Custódia, The role of miRNAs in the development of Glioblastoma multiforme, 2012. Trabalho de Conclusão de Curso (Licenciatura em Bioquímica) - Universidade de Coimbra (Orientador). |
Iniciação científica Scientific initiation |
1. |
Ricardo Silva, Evaluation of astrocyte proliferation in the presence of inflammatory cytokines, 2011. Iniciação científica (Bioquímica) - Universidade de Coimbra (Orientador). |
2. |
Joan Ribeiro Guedes, TLR-dependent microglia activation and miRNA deregulation in Alzheimer's disease, 2009. (Orientador). |
Indicadores de produção
(Production indicators)
Produção científica
Scientific production |
Produção técnica
Technical production |
Dados complementares
data |
Produção científica Scientific production |
34 |
Livros e capítulos Books and book chapters |
3 |
Capítulos de livros publicados Published book chapters |
3 |
Artigos científicos em revistas Papers in periodics |
31 |
Com arbitragem científica With scientific refereeing |
8 |
Sem arbitragem científica Without scientific refereeing |
23 |
Produção técnica Technical production |
26 |
Outros tipos de produção técnica Other technical production |
26 |
Dados complementares (Additional data) |
6 |
Orientações Orientations |
6 |
Visualizações do curriculum [
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