Amélia Maria Lopes Dias da Silva
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Data da última atualização
»Last update
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30/07/2015 |
Dados pessoais (Personal data)
Nome completo
Full name |
Amélia Maria Lopes Dias da Silva |
Nome em citações bibliográficas
Quoting name |
Silva, Amélia Maria Lopes Dias da |
Categoria profissional
Position |
Professor Auxiliar |
Domínio científico de atuação
Scientific domain |
Ciências Naturais-Ciências Biológicas.
Ciências Médicas-Ciências da Saúde.
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Endereço profissional
Professional address |
Universidade de Trás-os-Montes e Alto Douro
Escola de Ciências da Vida e do Ambiente
Departamento de Biologia e Ambiente
Departamento de Biologia
Vila Real
5001-801 Vila Real
Portugal
Apartado: 1013
Telefone: (+351)259350106Extensão: 2106
Correio electrónico: amsilva@utad.pt |
Sexo
Gender |
Feminino»Female |
Graus Académicos
(Academic Degrees)
| 2003 |
Doutoramento
Phd |
Bioquímica (especialidade Biofísica Celular).
Universidade de Coimbra,
Portugal.
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| 1992-1995 |
Mestrado
Master degree |
Biologia Celular
(2 anos » years)
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Universidade de Coimbra,
Portugal.
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| 1987-1992 |
Licenciatura
Licentiate degree |
Bioquímica
(5 anos » years)
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Universidade de Coimbra,
Portugal.
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Vínculos profissionais
(Professional Positions)
| Universidade de Trás-os-Montes e Alto Douro |
| Mar/2003-Actual |
Professor Auxiliar |
Produção científica, técnica e artística/cultural
(Scientific, technical and artistical/cultural
production)
Capítulos de livros publicados
Published book chapters |
| 1. |
Andreani, Tatiana; Souza, Ana L. R; SILVA, Amélia M; Souto, Eliana B. 2012. Sol–Gel Carrier System: A Novel Controlled Drug Delivery. In Patenting Nanomedicines, ed. Eliana B. Souto, 151 - 166. ISBN: 978-3-642-29264-4. Berlin, Heidelberg: Springer Berlin Heidelberg.
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| 2. |
SANTOS, Rosa M; Barbosa, Rui M; Silva, Amélia M; Antunes, Célia M; Rosario, Luis M. 1994. [Ca2+]i-sensitive conductance in the regulation of pancreatic b-cell bursting. In Frontiers of Insulin Secretion and Pancreatic b-cell Research , ed. P. R. Flatt, & Lenzen, S.,, 181 - 186. . U.K.: Smith-Gordon. |
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Artigos em revistas com arbitragem científica
Papers in periodics with scientific refereeing |
| 1. |
Severino, Patrícia; Szymanski, Marcelo; Favaro, Marianna; Azzoni, Adriano R; Chaud, Marco V; Santana, Maria H. A; SILVA, Amélia M; Souto, Eliana B. 2015. "Development and characterization of a cationic lipid nanocarrier as non-viral vector for gene therapy", European Journal of Pharmaceutical Sciences 66, -: 78 - 82.
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| 2. |
Soares, Jorge P; Silva, Amélia M; Fonseca, Sandra; Oliveira, Maria M; Peixoto, Francisco; Gaivão, Isabel; Mota, Maria P. 2015. "How can age and lifestyle variables affect DNA damage, repair capacity and endogenous biomarkers of oxidative stress?", Experimental Gerontology 62, -: 45 - 52.
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| 3. |
Andreani, Tatiana; SILVA, Amélia M; Souto, Eliana B. 2015. "Silica based-matrices: State of the art and new perspectives for therapeutic drug delivery", Biotechnology and Applied Biochemistry n, -: n/a - n/a.
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| 4. |
Fangueiro, Joana F; SILVA, Amélia M; Garcia, Maria L; Souto, Eliana B. 2015. "Current nanotechnology approaches for the treatment and management of diabetic retinopathy", European Journal of Pharmaceutics and Biopharmaceutics, -: na - na.
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| 5. |
Vazzana, M.; Andreani, T.; Fangueiro, J.; Faggio, C.; Silva, C.; Santini, A.; Garcia, M.L.; Silva, A.M.; Souto, E.B.. 2015. "Tramadol hydrochloride: Pharmacokinetics, pharmacodynamics, adverse side effects, co-administration of drugs and new drug
delivery systems", Biomedicine & Pharmacotherapy 70, 2015: 234 - 238.
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| 6. |
Andreani, Tatiana; Miziara, Leonardo; Lorenzón, Esteban N; de Souza, A. L. R; Kiill, Charlene P; Fangueiro, Joana F; Garcia, Maria L; Gremião, Palmira D; SILVA, Amélia M; Souto, Eliana B. 2015. "Effect of mucoadhesive polymers on the in vitro performance of insulin-loaded silica nanoparticles: Interactions with mucin
and biomembrane models", European Journal of Pharmaceutics and Biopharmaceutics 93, -: 118 - 126.
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| 7. |
Andreani, Tatiana; Kiill, Charlene P; de Souza, A. L. R; Fangueiro, Joana F; Doktorovová, Slavomira; Garcia, Maria L; Gramião, Maria P. D; SILVA, Amélia M; Souto, Eliana B. 2015. "Effect of cryoprotectants on the reconstitution of silica nanoparticles produced by sol–gel technology", Journal of Thermal Analysis and Calorimetry 120, 1: 1001 - 1007.
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| 8. |
Andreani, Tatiana; Fangueiro, Joana; Jose, Sajan; Santini, Antonello; Silva, Amelia; Souto, Eliana. 2015. "Hydrophilic Polymers for Modified-Release Nanoparticles: A Review of Mathematical Modelling for Pharmacokinetic Analysis", Current Pharmaceutical Design 21, 22: 3090 - 3096.
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| 9. |
Soares, Jorge P; SILVA, Amélia M; Oliveira, Maria M; Peixoto, Francisco; Gaivão, Isabel; Mota, Maria P. 2015. "Effects of combined physical exercise training on DNA damage and repair capacity: role of oxidative stress changes", AGE 37, 3: 1 - 12.
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| 10. |
Macedo, Ana S; Quelhas, Sara; SILVA, Amélia M; Souto, Eliana B. 2014. " Nanoemulsions for delivery of flavonoids: formulation and in vitro release of rutin
as model drug ", Pharmaceutical Development and Technology 19, 6: 677 - 680.
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| 11. |
Doktorovova, Slavomira; Shegokar, Ranjita; Fernandes, Lisete; Martins-Lopes, Paula; SILVA, Amélia M; Müller, Rainer H; Souto, Eliana B. 2014. "Trehalose is not a universal solution for solid lipid nanoparticles freeze-drying", Pharmaceutical Development and Technology 19, 8: 922 - 929.
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| 12. |
Doktorovova, Slavomira; SILVA, Amélia M; Gaivão, Isabel; Souto, Eliana B; Teixeira, João P; Martins-Lopes, Paula. 2014. "Comet assay reveals no genotoxicity risk of cationic solid lipid nanoparticles", Journal of Applied Toxicology 34, 4: 395 - 403.
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| 13. |
Monteiro-Cardoso, Vera F; SILVA, Amélia M; Oliveira, Maria M; Peixoto, Francisco; Videira, Romeu A. 2014. "Membrane lipid profile alterations are associated with the metabolic adaptation of the Caco-2 cells to aglycemic nutritional
condition", Journal of Bioenergetics and Biomembranes 46, 1: 45 - 57.
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| 14. |
Fangueiro, Joana F; Andreani, Tatiana; Egea, Maria A; Garcia, Maria L; Souto, Selma B; SILVA, Amélia M; Souto, Eliana B. 2014. "Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicity", International Journal of Pharmaceutics 461, 1-2: 64 - 73.
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| 15. |
Souza, Ana L. R.; Andreani, Tatiana; de Oliveira, R. N; Kiill, Charlene P; Santos, Fernanda K.; Allegretti, Silmara M; Chaud, Marco V; Souto, Eliana B; SILVA, Amélia M; Gremião, Maria P. D. 2014. "In vitro evaluation of permeation, toxicity and effect of praziquantel-loaded solid lipid nanoparticles against Schistosoma
mansoni as a strategy to improve efficacy of the schistosomiasis treatment", International Journal of Pharmaceutics 463, 1: 31 - 37.
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| 16. |
Doktorovova, Slavomira; Souto, Eliana B; SILVA, Amélia M. 2014. "Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers – A systematic review of in vitro data", European Journal of Pharmaceutics and Biopharmaceutics 87, 1: 1 - 18.
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| 17. |
Sousa, Cristina P; Azevedo, Jorge T; SILVA, Amélia M; Viegas, Carlos A; Reis, Rui L; Gomes, Manuela E; Dias, Isabel R. 2014. "Serum total and bone alkaline phosphatase levels and their correlation with serum minerals over the lifespan of sheep", Acta Veterinaria Hungarica 62, 2: 205 - 214.
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| 18. |
Doktorovová, Slavomira; Santos, Dario L; Costa, Inês; Andreani, Tatiana; Souto, Eliana B; SILVA, Amélia M. 2014. "Cationic solid lipid nanoparticles interfere with the activity of antioxidant enzymes in hepatocellular carcinoma cells", International Journal of Pharmaceutics 471, 1-2: 18 - 27.
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| 19. |
Severino, Patrícia; Andreani, Tatiana; Jäger, Alessandro; Chaud, Marco V; Santana, Maria H. A; SILVA, Amélia M; Souto, Eliana B. 2014. "Solid lipid nanoparticles for hydrophilic biotech drugs: Optimization and cell viability studies (Caco-2 & HEPG-2 cell lines)", European Journal of Medicinal Chemistry 81, -: 28 - 34.
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| 20. |
Andreani, Tatiana; Souza, Ana L. R.; Kiill, Charlene P; Lorenzón, Esteban N; Fangueiro, Joana F; Calpena, Ana C; Chaud, Marco V; Garcia, Maria L; Gremião, Maria P. D; SILVA, Amélia M; Souto, Eliana B. 2014. "Preparation and characterization of PEG-coated silica nanoparticles for oral insulin delivery", International Journal of Pharmaceutics 473, 1-2: 627 - 635.
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| 21. |
Fangueiro, Joana F; Parra, Alexander; SILVA, Amélia M; Egea, Maria A; Souto, Eliana B; Garcia, Maria L; Calpena, Ana C. 2014. "Validation of a high performance liquid chromatography method for the stabilization of epigallocatechin gallate", International Journal of Pharmaceutics 475, 1-2: 181 - 190.
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| 22. |
Andreani, Tatiana; Kiill, Charlene P; Souza, Ana L. R.; Fangueiro, Joana F; Fernandes, Lisete; Doktorovová, Slavomira; Santos, Dario L; Garcia, Maria L; Gremião, Maria P. D; Souto, Eliana B; SILVA, Amélia M. 2014. "Surface engineering of silica nanoparticles for oral insulin delivery: Characterization and cell toxicity studies", Colloids and Surfaces B: Biointerfaces 123, -: 916 - 923.
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| 23. |
Fangueiro, Joana F; Andreani, Tatiana; Fernandes, Lisete; Garcia, Maria L; Egea, Maria A; SILVA, Amélia M; Souto, Eliana B. 2014. "Physicochemical characterization of epigallocatechin gallate lipid nanoparticles (EGCG-LNs) for ocular instillation", Colloids and Surfaces B: Biointerfaces 123, -: 452 - 460.
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| 24. |
Silva, Amélia M; Miranda, Andreia; Fernandes, Elisabete; Santos, Susana; Fraga, Irene; Santos, Dario L; Dias, Albino A; Bezerra, Rui M. 2013. "Endopolysaccharides from Ganoderma resinaceum, Phlebia rufa, and Trametes versicolor Affect Differently the Proliferation
Rate of HepG2 Cells", Applied Biochemistry and Biotechnology 169, 6: 1919 - 1926.
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| 25. |
Santos, Isis S; Ponte, Bruno M; Boonme, Prapaporn; Silva, Amélia M; Souto, Eliana B. 2013. "Nanoencapsulation of polyphenols for protective effect against colon–rectal cancer", Biotechnology Advances 31, 5: 514 - 523.
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| 26. |
Andreani, Tatiana; Sofia Macedo, A; F. Ferreira, S; M. Silva, A; Rosmaninho, Aristoteles; B. Souto, E. 2012. "Topical Targeting Therapies for Sexually Transmitted Diseases", Current Nanoscience 8, 4: 486 - 490.
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| 27. |
Severino, Patrícia; Andreani, Tatiana; Macedo, Ana S; Fangueiro, Joana F; Santana, Maria H. A; Silva, Amélia M; Souto, Eliana B. 2012. "Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery", Journal of Drug Delivery 2012, 2012: 1 - 10.
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| 28. |
Doktorovova, S.; Shegokar, R.; Martins-Lopes, P.; Silva, A.M.; Lopes, C.M.; Müller, R.H.; Souto, E.B.. 2012. "Modified Rose Bengal assay for surface hydrophobicity evaluation of cationic solid lipid nanoparticles (cSLN)", European Journal of Pharmaceutical Sciences 45, 5: 606 - 612.
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| 29. |
Souza, Ana L. R; Andreani, Tatiana; Nunes, Fernando M; Cassimiro, Douglas L; Almeida, Adélia E; Ribeiro, Clóvis A; Sarmento, Victor H. V; Gremião, Maria P. D; Silva, Amélia M; Souto, Eliana B. 2011. "Loading of praziquantel in the crystal lattice of solid lipid nanoparticles", Journal of Thermal Analysis and Calorimetry 108, 1: 353 - 360.
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| 30. |
Doktorovova, S.; Shegokar, R.; Rakovsky, E.; Gonzalez-Mira, E.; Lopes, C.M.; Silva, A.M.; Martins-Lopes, P.; Muller, R.H.; Souto, E.B.. 2011. "Cationic solid lipid nanoparticles (cSLN): Structure, stability and DNA binding capacity correlation studies", International Journal of Pharmaceutics 420, 2: 341 - 349.
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| 31. |
Dias, I.R.; Viegas, C.A.; Silva, A.M.; Pereira, H.F.; Sousa, C.P.; Carvalho, P.P.; Cabrita, A.S.; Fontes, P.J.; Silva, S.R.; Azevedo, J.M.T.. 2010. "Haematological and biochemical parameters in Churra-da-Terra-Quente ewes from the northeast of Portugal", ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA 62, 2: 265 - 272.
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| 32. |
Souto, Eliana B; Martins-Lopes, Paula; Lopes, Carla M; Gaivão, Isabel; Silva, Amélia M; Guedes-Pinto, Henrique. 2009. "A Note on Regulatory Concerns and Toxicity Assessment in Lipid-Based Delivery Systems (LDS)", Journal of Biomedical Nanotechnology 5, 4: 317 - 322.
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| 33. |
 Misler, Stanley; Zhou, Zhuan; Dickey, Adam S; Silva, Amelia M; Pressel, David M; Barnett, David W. 2009. " Electrical activity and exocytotic correlates of biphasic insulin secretion from ß-cells of canine islets of
Langerhans: Contribution of tuning two modes of Ca 2+ entry-dependent exocytosis to two modes of
glucose-induced electrical activity ", Channels 3, 3: 181 - 193.
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| 34. |
Misler, Stanley; Silva, Amelia M; Barnett, David W; Dickey, Adam S. 2009. "Phasic and tonic modes of depolarization-exocytosis coupling in ß-cells of porcine islets of Langerhans", Channels 3, 2: 101 - 109.
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| 35. |
Silva, Amelia M; Dickey, Adam S; Barnett, David W; Misler, Stanley. 2009. "Ion channels underlying stimulus-exocytosis coupling and its cell-to-cell heterogeneity in ß-cells of transplantable porcine
islets of Langerhans", Channels 3, 2: 91 - 100.
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| 36. |
Rosário, Luís M; BARBOSA, Rui M; ANTUNES, Célia M; BALDEIRAS, Inês E; SILVA, Amélia M; TOMÉ, Ângelo R; SANTOS, Rosa M. 2008. "Regulation by Glucose of Oscillatory Electrical Activity and 5-HT/Insulin Release from Single Mouse Pancreatic Islets in Absence
of Functional KATP Channels", Endocrine Journal 55, 4: 639 - 650.
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| 37. |
Silva, Amélia M; Rodrigues, Ricardo J; Tomé, Ângelo R; Cunha, Rodrigo A; Misler, Stanley; Rosário, Luís M; Santos, Rosa M. 2008. "Electrophysiological and Immunocytochemical Evidence for P2X Purinergic Receptors in Pancreatic ß Cells", Pancreas 36, 3: 279 - 283.
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| 38. |
Morais, Raul; Valente, A.; Almeida, J.C.; Silva, Amélia M; Soares, Salviano; Reis, M.J.C.S.; Valentim, R.; Azevedo, Jorge. 2006. "Concept study of an implantable microsystem for electrical resistance and temperature measurements in dairy cows, suitable
for estrus detection", Sensors and Actuators A: Physical 132, 1: 354 - 361.
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| 39. |
Silva, A. M; Liu-Gentry, J.; Dickey, A.S.; Barnett, D.W.; Misler, S.. 2005. "alpha-Latrotoxin increases spontaneous and depolarization-evoked exocytosis from pancreatic islet beta-cells", JOURNAL OF PHYSIOLOGY-LONDON 565, 3: 783 - 799.
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| 40. |
Barbosa, Rui M; Silva, Amelia M; Tome, Angelo R; Stamford, Jonathan A; Santos, Rosa M; Rosario, Luis M. 1998. "Control of pulsatile 5-HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics", JOURNAL OF PHYSIOLOGY-LONDON 510, 1: 135 - 143.
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| 41. |
Santos, R. M; Barbosa, R.M.; C.M., Antunes.; Silva, A.M.; Salgado, A.P.; Abrunhosa, A.J.; Pereira, F.C.; Seiça, R.M.; Rosário, L.M.. 1997. "Bursting electrical activity generated in the presence of KATP channel blockers. Pharmacology, sensitivity to intracellular
pH and modulation by glucose metabolism", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 426: 33 - 45. |
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| 42. |
Barbosa, Rui M; Silva, Amélia M; Tome, Angelo R; Stamford, Jonathan A; Santos, Rosa M; Rosario, Luis M. 1996. "Real Time Electrochemical Detection of 5-HT/Insulin Secretion from Single Pancreatic Islets: Effect of Glucose and K+Depolarization", Biochemical and Biophysical Research Communications 228, 1: 100 - 104.
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| 43. |
Salgado, A.P.; Silva, A.M.; Santos, R. M; Rosário, L.M.. 1996. "Multiphasic action of glucose and alpha-keto isocaproic acid on the intracellular pH of isolated mouse pancreatic beta-cells.", Journal of Biological Chemistry 271, 15: 8738 - 8467. |
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| 44. |
Silva, Amélia M; Rosario, Luis M; Santos, Rosa M. 1994. "Background Ca2+ influx mediated by a dihydropyridine- and voltage insensitive channel in pancreatic *-cells: modulation by
Ni2+, diphenylamine-2-carboxylate and glucose metabolism. ", Journal of Biological Chemistry 269, 25: 17095 - 17103. |
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| 45. |
Rosario, Luis M; Barbosa, Rui M; Antunes, Célia M; Silva, Amélia M; Abrunhosa, Antero J; Santos, Rosa M. 1993. "Bursting electrical activity in pancreatic beta-cells: evidence that the channel underlying the burst is sensitive to Ca2+
influx through L-type Ca2+ channels", Pflugers Archiv European Journal of Physiology 424, 5-6: 439 - 447.
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| 46. |
Santos, Rosa M; Barbosa, Rui M; Silva, Amélia M; Antunes, Célia M; Rosario, Luis M. 1992. "High external Ca2+ levels trigger membrane potential oscillations in mouse pancreatic ß-cells during blockade of K(ATP) channels", Biochemical and Biophysical Research Communications 187, 2: 872 - 879.
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Indicadores de produção
(Production indicators)
Produção científica
Scientific production |
Produção científica
Scientific production |
48 |
Livros e capítulos
Books and book chapters |
2 |
Capítulos de livros publicados
Published book chapters |
2 |
Artigos científicos em revistas
Papers in periodics |
46 |
Com arbitragem científica
With scientific refereeing |
46 |
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