Curriculum Vitae

Carla Lopes Varela

Data da última atualização »Last update : 25/09/2014


Carla Lopes Varela. Concluiu Mestrado Integrado em Ciências Farmacêuticas pela Universidade de Coimbra em 2008. Frequenta Doutoramento em Farmácia, especialidade de Química Farmacêutica pela Universidade de Coimbra desde 2009. É Investigador Auxiliar na Universidade de Coimbra. Publicou 5 artigos em revistas especializadas e 8 trabalhos em actas de eventos. Possui 46 itens de produção técnica. Participou em 7 eventos no estrangeiro e 11 em Portugal. Orientou 4 trabalhos de conclusão de curso de bach./licenciatura e 11 trabalhos de iniciação científica nas áreas de Ciências da Saúde e Química. Recebeu 12 prémios e/ou homenagens. Actualmente participa em 1 projecto de investigação. Actua nas áreas de Ciências Médicas com ênfase em Ciências da Saúde e Ciências Exactas com ênfase em Química. Nas suas actividades profissionais interagiu com 49 colaboradores em co-autorias de trabalhos científicos.


Endereço de acesso a este CV:

http://www.degois.pt/visualizador/curriculum.jsp?key=1403173880041620


Dados pessoais (Personal data)
Nome completo
Full name
Carla Lopes Varela
Nome em citações bibliográficas
Quoting name
Varela, Carla L.
Categoria profissional
Position
Investigador Auxiliar
Domínio científico de atuação
Scientific domain
Ciências Médicas-Ciências da Saúde.
Ciências Exactas-Química.
Endereço profissional
Professional address
Universidade de Coimbra
Faculdade de Farmácia
Pólo das Ciências da Saúde Azinhaga de Santa Comba
Coimbra
3000--548 Coimbra
Portugal
Telefone: (+351)239488400Extensão: 17635
Correio electrónico: carla.varela@portugalmail.com
Sexo
Gender
Feminino»Female




Graus Académicos (Academic Degrees)
2009-2013 Doutoramento
Phd
Doutoramento em Farmácia, especialidade de Química Farmacêutica (4 anos » years) .
Universidade de Coimbra, Portugal.

2002-2008 Licenciatura
Licentiate degree
Mestrado Integrado em Ciências Farmacêuticas (6 anos » years) .
Universidade de Coimbra, Portugal.





Vínculos profissionais (Professional Positions)
Universidade de Coimbra
Jul/2013-Actual Investigador Auxiliar

Universidade de Coimbra
Abr/2009-Mar/2013 Outra Situação

Farmácia Castanheira de Febres, Cantanhede
Mar/2008-Mar/2009 Outra Situação

Universidade de Coimbra
Jan/2002-Jan/2008 Outra





Atividades de Investigação e Desenvolvimento (Research and Development activities)


Estágios realizados (Traineeships)


Universidade de Coimbra
Ago/2007-Ago/2007
Estágios realizados»Traineeships:

   - Scientific research internship at the Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, University of Coimbra


Mar/2007-Jun/2007
Estágios realizados»Traineeships:

   - Scientific research project at the Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, University of Coimbra, within the subject of Chemical and Enzymatic Synthesis


Ago/2006-Ago/2006
Estágios realizados»Traineeships:

   - Internship at the Pharmacy Romahnja in Belgrade, Serbia, under the SEP program (Students Exchange Program)


Ago/2005-Ago/2005
Estágios realizados»Traineeships:

   - Internship at the Pharmacy Galeno, Vila Real


Ago/2004-Ago/2004
Estágios realizados»Traineeships:

   - Internship at the Pharmacy of the Hospital Centre of Trás-os-Montes e Alto Douro, Vila Real






Linhas de Investigação (Research fields)
1. Design, synthesis and structure-activity relationships studies on steroidal aromatase and 5alpha-reductase inhibitors as anti-tumors
2. Design and synthesis of coumarins as potential aromatase inhibitors




Projetos de Investigação (Research projects)
Outro Tipo de Participação
Other kind of participation
2012-
New Enzymatic Inhibitors Against Breast and Prostate Cancer: A Contribution To Ameliorate the Bone Loss and Endocrine Resistance
Referência do projeto»Project reference: PTDC/QUI-BIQ/120319/2010.






Línguas (Languages)
Compreende
Understandig
Inglês (Bem), Espanhol (Razoavelmente), Francês (Razoavelmente).
Fala
Speaking
Inglês (Bem), Espanhol (Razoavelmente).

Reading
Inglês (Bem), Espanhol (Razoavelmente), Francês (Razoavelmente).
Escreve
Writing
Inglês (Bem).




Prémios e títulos (Awards Prizes, and Honours)
2013 ESMEC fellowship to attend the 33rd edition of the European School of Medicinal Chemistry, Urbino, Italy, 7-12 July 2013, Scientific Committee of the European School of Medicinal Chemistry (ESMEC- Urbino) and the European .
2012 Best Oral Communication in the “Drug Discovery” area, presented at the Conference CEF 2012, Hovione, Center for Pharmaceutical Studies and Faculty of Pharmacy .
2005 Award given as the first author for the best oral communication entitled “Separation and collection of urban solid waste: habits and attitudes”, Portuguese Pharmacists Association .
2009 Scholarship SFRH/BD/44872/2008, Fundação para a Ciência e a Tecnologia Ministério da Educação e Ciência .
2012 Bentham scholarship under the “XXII International Symposium on Medicinal Chemistry”, Berlin, Germany, 2-6 of September of 2012, Bentham and European Federation of Medicinal Chemistry.
2010 Award for the 3% best students of each course, for the academic year of 2006/2007, University of Coimbra.
2010 Bentham scholarship under the “XXI International Symposium on Medicinal Chemistry”, Brussels, Belgium, 5-9 of September of 2010, Bentham .
2010 Scholarship from the European Federation on Medicinal Chemistry under the “XXI International Symposium on Medicinal Chemistry”, Brussels, Belgium, 5-9 of September of 2010, European Federation on Medicinal Chemistry.
2008 Award “Sociedade Farmacêutica Lusitana” that distinguishes the young pharmacists who have concluded their academic degree in Portugal with the highest classification, Portuguese Pharmacists Association.
2008 Award for the 3% best students of each course, for the academic year of 2005/2006, University of Coimbra.
2007 Award for the 3% best students of each course, for the academic year of 2004/2005, University of Coimbra.
2005 Award Paracelsus given to the student with best grade of the subject Organic Chemistry, Rectory of the University of Coimbra.




Membro de Associações Profissionais/Científicas (Professional/Scientific Association membership)
Ago/2008 - Actual Ordem dos Farmacêuticos, Membro.




Produção científica, técnica e artística/cultural (Scientific, technical and artistical/cultural production)
Artigos em revistas com arbitragem científica
Papers in periodics with scientific refereeing
1. Roleira, F. M. F; Tome , C; Bernardo, T.; Serafim, T.; Oliveira, Paulo J; Varela, Carla; Borges, Fernanda; Carvalho, R. A. 2011. "DESIGN, SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITIES OF CINNAMIC AND HYDROCINNAMIC ACID LIPOPHILIC DERIVATIVES", European Journal of Pharmaceutical Sciences 44, 1-2: 176 - 176.

Trabalhos completos/resumidos em eventos com arbitragem científica
Papers in conference proceedings with scientific refereeing
1. Varela, C.; Carvalho, R.; Oliveira, P.; Serafim, T.; Roleira, F.; Tavares-da-Silva, E.; Bernardo, T.; Borges, F.; Tome, C.. 2011. "DESIGN, SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITIES OF CINNAMIC AND HYDROCINNAMIC ACID LIPOPHILIC DERIVATIVES", Trabalho apresentado em 4th BBBB-Bled International Conference on Pharmaceutical Sciences - New Trends in Drug Discovery, Delivery Systems and Laboratory Diagnostics, In EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Bled, SLOVENIA.

Artigos em revistas sem arbitragem científica
Papers in periodics without scientific refereeing
1. Varela, Carla L; Roleira, Fernanda M. F; Costa, Saul C; Pinto, Alexandra S. C. T; Martins, Ana I. O. S; Carvalho, Rui A; Teixeira, Natércia; Correia-da-Silva, Georgina; Tavares-da-Silva, Elisiário J. 2014. "Insights Into the Synthesis of Steroidal A-ring Olefins", Helvetica Chimica Acta 97, 1: 39 - 46.
2. Varela, Carla L; Amaral, Cristina; Correia-da-Silva, Georgina; Carvalho, Rui A; Teixeira, Natércia A; Costa, Saul C; Roleira, Fernanda M; Tavares-da-Silva, Elisiário J. 2013. "Design, synthesis and biochemical studies of new 7a-allylandrostanes as aromatase inhibitors", Steroids 78, 7: 662 - 669.
3. Amaral, Cristina; Varela, Carla L; Azevedo, Margarida; da Silva, E. T; Roleira, Fernanda M; Chen, Shiuan; Correia-da-Silva, Georgina; Teixeira, Natércia. 2013. "Effects of Steroidal Aromatase Inhibitors on Sensitive and Resistant Breast Cancer Cells: Aromatase Inhibition and Autophagy", The Journal of Steroid Biochemistry and Molecular Biology 135, -: 51 - 59.
4. Amaral, Cristina; Varela, Carla L; Correia-da-Silva, Georgina; Tavares-da-Silva, Elisiário J; Carvalho, Rui A; Costa, Saul C; Cunha, Sara C; Fernandes, José O; Teixeira, Natércia; Roleira, Fernanda M. 2013. "New Steroidal 17ß-Carboxy Derivatives Present Anti-5a-Reductase Activity and Anti-proliferative Effects in a Human Androgen-Responsive Prostate Cancer Cell Line", Biochimie, 2013: 1 - 10.
5. Amaral, Cristina; Varela, Carla; Borges, Margarida; Tavares da S. E; Roleira, Fernanda M. F; Correia-da-Silva, Georgina; Teixeira, Natércia. 2013. "Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis", Apoptosis, -: 1 - 11.
6. Varela, Carla L; Tavares da S. E. J; Amaral, Cristina; Correia da S. G; Baptista, Teresa; Alcaro, Stefano; Costa, Giosuè; Carvalho, Rui A; Teixeira, Natércia A. A; Roleira, Fernanda M. F. 2012. "New Structure–Activity Relationships of A- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis, and Biochemical Evaluation", Journal of Medicinal Chemistry 55, 8: 3992 - 4002.
7. Andrade, L. C. R; Almeida, M. J. M.; Fernandes Roleira, F. M; Varela, Carla L; Tavares da S. E. J. 2012. "6-Methylideneandrost-4-ene-3,17-dione", Acta Crystallographica Section E Structure Reports Online 68, 4: o1263 - o1263.
8. Varela, Carla L; Andrade, L. C. R; Almeida, M. J. M.; Roleira, Fernanda M; Tavares-da-Silva, Elisiário J. 2008. "(E)-17-Oximino-5-alpha-androst-3-ene", Acta Crystallogr., C64,: o508 - o508.

Trabalhos completos/resumidos em eventos sem arbitragem científica
Papers in conference proceedings without scientific refereeing
1. Varela, Carla L; Tavares-da-Silva, Elisiário J; Lopes, A.; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Carvalho, Rui A; Ribeiro, P.; Teixeira, Natércia; Roleira, Fernanda M. 2014. "Exemestane Metabolites: Synthesis, Stereochemical Elucidation and Mechanism of Action in Breast Cancer", Trabalho apresentado em 22nd Conference on Isoprenoids, In CHEMICKE LISTY, Praga.
2. Varela, Carla L; Roleira, Fernanda M. F; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2014. "Exploring New Chemical Functionalities to Improve Aromatase Inhibition of Steroids ", Trabalho apresentado em 22nd Conference on Isoprenoids, In CHEMICKE LISTY, Praga.
3. Varela, Carla L; Roleira, Fernanda M; Costa, Saul C; Carvalho, Rui A; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2014. "Targeting Aromatase in Breast Cancer: New Steroidal Olefins and Epoxides as Aromatase Inhibitors and Structure-Activity Relationships", Trabalho apresentado em 22nd Conference on Isoprenoids, In CHEMICKE LISTY, Praga.
4. Varela, Carla L; Roleira, Fernanda M. F; Costa, Saul C; Carvalho, Rui A; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2013. "Steroidal Aromatase Inhibitors in Breast Cancer Research. Structure and Substrate-Guided Design, Synthesis and Structure-Activity Relationships (SAR)", Trabalho apresentado em 5th International BBBB Conference, In European Journal of Pharmaceutical Sciences, Atenas.
5. Varela, Carla L; Tavares-da-Silva, Elisiário J; Amaral, Cristina; Correia-da-Silva, Georgina; Carvalho, Rui A; Costa, Saul C; Cunha, S.; Fernandes, J.; Teixeira, Natércia; Roleira, Fernanda M. F. 2013. "Design, Synthesis and Evaluation of New Steroidal 17 -Carboxy Derivatives as 5a-Reductase Inhibitors", Trabalho apresentado em 5th International BBBB Conference, In European Journal of Pharmaceutical Sciences, Atenas.
6. Varela, Carla L; Roleira, Fernanda M. F; Lopes, A.; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2013. "Exemestane Potential Metabolites – Design, Synthesis and Studies in Breast Cancer Cells", Trabalho apresentado em 5th International BBBB Conference, In European Journal of Pharmaceutical Sciences, Atenas.
7. Roleira, Fernanda M; Tavares-da-Silva, Elisiário J; Varela, Carla L; Bernardo, T.; Serafim, T.; Oliveira, P.; Teixeira, J.; Garrido, J.; Borges, F.. 2012. "New Lipophilic Cinnamic Acid Derivatives. Correlation between Antioxidant and Antiproliferative Activities towards Breast Cancer Cell Lines", Trabalho apresentado em XXII International Symposium on Medicinal Chemistry , In ChemMedChem, Berlin.
8. Varela, Carla L; Tavares-da-Silva, Elisiário J; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Pinto, Alexandra S. C. T; Simões, Ana; Carvalho, Rui A; Teixeira, Natércia; Roleira, Fernanda M. F. 2012. "A-, B- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis and Biochemical Studies", Trabalho apresentado em XXII International Symposium on Medicinal Chemistry, In ChemMedChem, Berlin.
9. Roleira, Fernanda M. F; Tomé, C.; Bernardo, T.; Serafim, T.; Oliveira, P.; Varela, Carla L; Borges, F.; Carvalho, Rui A; Tavares-da-Silva, Elisiário J. 2011. "Design, Synthesis and Antiproliferative Activities of Cinnamic and Hydrocinnamic Acid Lipopilic Derivatives", Trabalho apresentado em 4th BBBB – Bled International Conference on Pharmaceutical Sciences, In European Journal of Pharmaceutical Sciences, Bled.
10. Varela, Carla L; Roleira, Fernanda M. F; Cepa, Margarida; Azevedo, Margarida; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2010. "Design Synthesis and Biological Evaluation Towards Aromatase of C-4 Derivatives of Formestane and 5alpha-Androst-3-en-17-one", Trabalho apresentado em XXI International Symposium on Medicinal Chemistry, In Drug Future, Brussels.
11. Varela, Carla L; Tavares-da-Silva, Elisiário J; Cepa, Margarida; Azevedo, Margarida; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Roleira, Fernanda M. 2010. "Structure-Activity Relationships on D-Ring Modified 3-Deoxy-3-Androstenes as Aromatase inhibitors", Trabalho apresentado em XI International Symposium on Medicinal Chemistry, In Drug Future, Brussels.
12. Varela, Carla L; Roleira, Fernanda M; Correia-da-Silva, Georgina; Cepa, Margarida; Dias, Ana; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2009. "Androstenes vs Epoxyandrostanes. The role of the Planarity of the A-Ring in Aromatase Inhibition. A Structure-Activity Study", Trabalho apresentado em Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies, In Drug Future, Barcelona.
13. Roleira, Fernanda M. F; Sintra, Tânia; Varela, Carla L; Correia-da-Silva, Georgina; Cepa, Margarida; Dias, Ana; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2009. "The Effect of C-3 Stereochemistry in the Aromatase Inhibitory Activity of 3-Hydroxy-4-Androstenes. A Structure-Activity Study", Trabalho apresentado em Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies, In Drug Future, Barcelona.
14. Tavares-da-Silva, Elisiário J; Cepa, Margarida; Correia-da-Silva, Georgina; Teixeira, Natércia; Varela, Carla L; Roleira, Fernanda M. 2008. "Structure-Activity Relationships on 4-Androstenes and 5alpha-Androstan-4-ones as Aromatase Inhibitors", Trabalho apresentado em XX International Symposium on Medicinal Chemistry , In Drug Future, Vienna.



Apresentação oral de trabalho
Oral work presentation
1. Varela, Carla L; Tavares-da-Silva, Elisiário J; Lopes, A.; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Carvalho, Rui A; Ribeiro, P.; Teixeira, Natércia; Roleira, Fernanda M. F. Exemestane Metabolites: Synthesis, Stereochemical Elucidation and Mechanism of Action in Breast Cancer,22nd Conference on Isoprenoids,Prague,2014 (Congresso).
2. Maurício, J.; Amaral, Cristina; Varela, Carla L; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M. F; Costa, Saul C; Correia-da-Silva, Georgina; Teixeira, Natércia. New 7a-allylandrostanes as Aromatase Inhibitors: Biological Effects in Hormone-dependent and Hormone-resistant Breast Cancer Cells,7th Meeting of Young Researchers at UP,Porto,2014 (Conferência ou palestra).
3. Amaral, Cristina; Lopes, A.; Varela, Carla L; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M; Correia-da-Silva, Georgina; Teixeira, Natércia. Effects of Exemestane Metabolites in Sensitive and Resistant Breast Cancer Cells: Role of Autophagy,Annual Meeting of the Portuguese Pharmacology Society,Coimbra,2014 (Congresso).
4. Varela, Carla L; Roleira, Fernanda M. F; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. Exploring New Chemical Functionalities to Improve Aromatase Inhibition of Steroids ,22nd Conference on Isoprenoids,Prague,2014 (Congresso).
5. Lemos, A.; Amaral, Cristina; Lopes, A.; Varela, Carla L; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M. F; Costa, Saul C; Teixeira, Natércia; Correia-da-Silva, Georgina. Biological Evaluation of New Steroidal Compounds: Aromatase Inhibition and Effects in MCF-7aro Cells Viability,7th Meeting of Young Researchers at UP,Porto,2014 (Poster).
6. Varela, Carla L; Roleira, Fernanda M. F; Costa, Saul C; Carvalho, Rui A; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. Targeting Aromatase in Breast Cancer: New Steroidal Olefins and Epoxides as Aromatase Inhibitors and Structure-Activity Relationships,22nd Conference on Isoprenoids ,Prague,2014 (Congresso).
7. Varela, Carla L; Roleira, Fernanda M; Costa, Saul C; Carvalho, Rui A; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia A; Tavares-da-Silva, Elisiário J. STEROIDAL AROMATASE INHIBITORS IN BREAST CANCER RESEARCH. STRUCTURE AND SUBSTRATE-GUIDED DESIGN, SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS (SAR) ,5th BBBB International Conference,2013 (Conferência ou palestra).
8. Varela, Carla L; Tavares-da-Silva, Elisiário J; Amaral, Cristina; Correia-da-Silva, Georgina; Carvalho, Rui A; Costa, Saul C; Cunha, S.; Fernandes, J.; Teixeira, Natércia A; Roleira, Fernanda M. F. NEW STEROIDAL 17ß-CARBOXY DERIVATIVES – DESIGN, SYNTHESIS AND EVALUATION AS 5a-REDUCTASE INHIBITORS,IV CEF Conference 2013,2013 (Comunicação).
9. Varela, Carla L. Design, Synthesis and Structure-activity Relationships Studies on Steroidal Aromatase and 5a-Reductase Inhibitors as Anti-tumors,European School of Medicinal Chemistry – XXXIII Advanced Course of Medicinal Chemistry and “E. Duranti” National Seminar for PhD Students,Urbino,2013 (Poster).
10. Varela, Carla L; Roleira, Fernanda M; Lopes, A.; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia A; Tavares-da-Silva, Elisiário J. EXEMESTANE POTENTIAL METABOLITES – DESIGN, SYNTHESIS AND STUDIES IN BREAST CANCER CELLS,5th BBBB International Conference,2013 (Poster).
11. Varela, Carla L; Roleira, Fernanda M; Lopes, A.; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia A; Tavares-da-Silva, Elisiário J. DESIGN, SYNTHESIS AND STUDY OF POTENTIAL METABOLITES OF EXEMESTANE IN BREAST CANCER CELLS,IV CEF Conference,2013 (Poster).
12. Lopes, A.; Amaral, Cristina; Varela, Carla L; Roleira, Fernanda M. F; Tavares-da-Silva, Elisiário J; Correia-da-Silva, Georgina; Teixeira, Natércia. Exemestane Metabolites: Effects on Breast Cancer Cell Proliferation and Induction of Cell Death,6th Meeting of Young Researchers at UP,Porto,2013 (Conferência ou palestra).
13. Varela, Carla L; Tavares-da-Silva, Elisiário J; Amaral, Cristina; Correia-da-Silva, Georgina; Carvalho, Rui A; Costa, Saul C; Cunha, S.; Fernandes, J.; Teixeira, Natércia; Roleira, Fernanda M. DESIGN, SYNTHESIS AND EVALUATION OF NEW STEROIDAL 17ß-CARBOXY DERIVATIVES AS 5a-REDUCTASE INHIBITORS,5yh BBBB International Conference,2013 (Poster).
14. Amaral, Cristina; Varela, Carla L; Borges, M.; Roleira, Fernanda M. F; Tavares-da-Silva, Elisiário J; Correia-da-Silva, Georgina; Teixeira, Natércia. The Aromatase Inhibitors Androst-4-en-17-one and 4a,5a-Epoxyandrostan-17-one: Biological Effects in an Estrogen Receptor-Positive Aromatase-Overexpressing Breast Cancer Cell Line (MCF-7aro),Cell Death in Cancer Conference – EACR,Amsterdam,2012 (Poster).
15. Varela, Carla L; Tavares-da-Silva, Elisiário J; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Pinto, Alexandra S. C. T; Simões, Ana; Carvalho, Rui A; Teixeira, Natércia; Roleira, Fernanda M. A-, B- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis and Biochemical Studies,XXII International Symposium on Medicinal Chemistry,Berlin,2012 (Poster).
16. Varela, Carla L; Tavares-da-Silva, Elisiário J; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Pinto, Alexandra S. C. T; Simões, Ana; Carvalho, Rui A; Teixeira, Natércia; Roleira, Fernanda M. F. Structure-Activity Relationships of A-, B- and D-Ring Modified Steroidal Aromatase Inhibitors,Conference CEF 2012,Coimbra,2012 (Conferência ou palestra).
17. Amaral, Cristina; Varela, Carla L; Azevedo, Margarida; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M; Chen, S.; Correia-da-Silva, Georgina; Teixeira, Natércia. Effects of New Steroidal Aromatase Inhibitors on Sensitive and Resistant Breast Cancer Cells,One Day Symposium on Darwinian evolution and clonal heterogeneity in human cancer: biological and clinical implications,Porto,2012 (Poster).
18. Roleira, Fernanda M. F; Tavares-da-Silva, Elisiário J; Varela, Carla L; Bernardo, T.; Serafim, T.; Oliveira, P.; Teixeira, J.; Garrido, J.; Borges, F.. Cinnamic Acid Derivatives. Design, Synthesis, Antioxidant Profile and Antiproliferative Activities Towards Breast Cancer Cell Lines,Conference CEF 2012,Coimbra,2012 (Poster).
19. Lopes, A.; Amaral, Cristina; Varela, Carla L; Roleira, Fernanda M; Tavares-da-Silva, Elisiário J; Correia-da-Silva, Georgina; Teixeira, Natércia. Comparative Study of Exemestane Metabolites in a Breast Cancer Cell Model,XXI Porto Cancer Meeting – Metabolism and Cancer, from etiopathogenesis to therapy,Porto,2012 (Poster).
20. Roleira, Fernanda M. F; Tavares-da-Silva, Elisiário J; Varela, Carla L; Bernardo, T.; Serafim, T.; Oliveira, P.; Teixeira, J.; Garrido, J.; Borges, F.. New Lipophilic Cinnamic Acid Derivatives. Correlation between Antioxidant and Antiproliferative Activities towards Breast Cancer Cell Lines,XXII International Symposium on Medicinal Chemistry,Berlin,2012 (Poster).
21. Amaral, Cristina; Azevedo, Margarida; Borges, M.; Varela, Carla L; Roleira, Fernanda M; Tavares-da-Silva, Elisiário J; Correia-da-Silva, Georgina; Teixeira, Natércia. Effects of Two Aromatase Inhibitors in Cell Proliferation and Cell Death in an Estrogen-dependent Breast Cancer Cell Line (MCF-7aro),Second I3S Scientific Retreat,Porto,2011 (Poster).
22. Roleira, Fernanda M; Tomé, C.; Bernardo, T.; Serafim, T.; Oliveira, P.; Varela, Carla L; Borges, F.; Carvalho, Rui A; Tavares-da-Silva, Elisiário J. Desing, Synthesis and Antiproliferativo Activities of Cinnamic and Hydrocinnamic Acid Lipopilic Derivatives,4th BBBB – Bled International Conference on Pharmaceutical Sciences,Bled,2011 (Poster).
23. Amaral, Cristina; Azevedo, Margarida; Borges, M.; Varela, Carla L; Cepa, Margarida; Roleira, Fernanda M. F; Tavares-da-Silva, Elisiário J; Correia-da-Silva, Georgina; Teixeira, Natércia. Effects of Two Steroidal Aromatase Inhibitors in an Estrogen Receptor-Positive Aromatase-Overexpressing Breast Cancer Cell Line (Mcf-7aro),XX Porto Cancer Meeting,Porto,2011 (Poster).
24. Varela, Carla L. Seeking for a New Framework in Steroids Aiming Aromatase Inhibition,2nd ScienCEF,Coimbra,2011 (Conferência ou palestra).
25. Varela, Carla L; Tavares-da-Silva, Elisiário J; Costa, Saul C; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Roleira, Fernanda M. F. Design, Synthesis and Biochemical Screening Towards Aromatase of C-17 Derivatives of 7a-Allylandrostenedione As Well As Its 1-Ene and 3-Deoxo Analogs,Frontiers in Medicinal Chemistry Meeting,Stockholm,2011 (Poster).
26. Amaral, Cristina; Azevedo, Margarida; Varela, Carla L; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M. F; Correia-da-Silva, Georgina; Teixeira, Natércia. Effects of A- and D-Ring Modified Steroids in Aromatase Activity,2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery,Porto,2011 (Poster).
27. Varela, Carla L; Roleira, Fernanda M. F; Costa, Saul C; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. New Structure-Activity Relationships (SAR) of 7a-Allyl Derivatives of Androstenedione as Aromatase Inhibitors Towards Breast Cancer Research,Conference CEF 2011,Coimbra,2011 (Poster).
28. Roleira, Fernanda M; Tomé, C.; Bernardo, T.; Serafim, T.; Oliveira, P.; Varela, Carla L; Borges, F.; Tavares-da-Silva, Elisiário J. Lipophilic Derivatives of Cinnamic and Hydrocinnamic Acids. Design, Synthesis and Antiproliferative Activities,Conference CEF 2011,Coimbra,2011 (Poster).
29. Varela, Carla L; Roleira, Fernanda M. F; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. Structure-Activity Relationships of A-, B- and D-Ring Modified Steroidal Aromatase Inhibitors,2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery,Porto,2011 (Congresso).
30. Varela, Carla L; Roleira, Fernanda M; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. New A-Ring Steroidal Olefins and Epoxides as Aromatase Inhibitors. Design, Synthesis, Biochemical Evaluation and SAR,Frontiers in Medicinal Chemistry Meeting,Stockholm,2011 (Poster).
31. Dias, Ana; Correia-da-Silva, Georgina; Amaral, Cristina; Borges, M.; Cepa, Margarida; Varela, Carla L; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M. F; Teixeira, Natércia. Two New Aromatase Inhibitors: Biological Evaluation and Effects in an Estrogen-Dependent Breast Cancer Cell Line,3rd Meeting of Young Researchers of U. Porto,Porto,2010 (Conferência ou palestra).
32. Varela, Carla L; Tavares-da-Silva, Elisiário J; Cepa, Margarida; Azevedo, Margarida; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Roleira, Fernanda M. F. Structure-Activity Relationships on D-Ring Modified 3-Deoxy-3-Androstenes as Aromatase inhibitors,XXI International Symposium on Medicinal Chemistry,Brussels,2010 (Poster).
33. Varela, Carla L; Roleira, Fernanda M; Amaral, Cristina; Correia-da-Silva, Georgina; Azevedo, Margarida; Cepa, Margarida; Teixeira, Natércia; Alcaro, S.; Costa, G.; Tavares-da-Silva, Elisiário J. Steroidal Aromatase Inhibitors in Breast Cancer Research. New Structure-Activity Relationships (SAR) and Docking Studies on Androstenedione Based Inhibitors,Conference CEF 2010,Coimbra,2010 (Poster).
34. Amaral, Cristina; Azevedo, Margarida; Varela, Carla L; Cepa, Margarida; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M; Correia-da-Silva, Georgina; Teixeira, Natércia. New A-D-ring Modified Steroids as Aromatase Inhibitors: Structure-Activity Relationship Studies,I3S Scientific Retreat,Porto,2010 (Poster).
35. Amaral, Cristina; Azevedo, Margarida; Borges, M.; Varela, Carla L; Cepa, Margarida; Roleira, Fernanda M. F; Tavares-da-Silva, Elisiário J; Correia-da-Silva, Georgina; Teixeira, Natércia. Effects of Two Aromatase Inhibitors in Cell Proliferation and Cell Death in an Estrogen-dependent Breast Cancer Cell Line,Eighth International Conference on Mechanisms of Cell Death and Disease. Advances in Therapeutic Intervention and Drug Development,Cascais,2010 (Poster).
36. Varela, Carla L. Looking for Chemical Key-features in the A-ring of Steroids Aiming Inhibition of Aromatase,1st ScienCEF,Coimbra,2010 (Conferência ou palestra).
37. Amaral, Cristina; Azevedo, Margarida; Mota, V.; Varela, Carla L; Cepa, Margarida; Roleira, Fernanda M; Correia-da-Silva, Georgina; Teixeira, Natércia. A- and D-Rings Modified Steroids as Potential Aromatase Inhibitors: Aromatase Activity Evaluation and Kinetic Studies,XVII National Biochemistry Congress,Porto,2010 (Poster).
38. Varela, Carla L; Roleira, Fernanda M; Cepa, Margarida; Azevedo, Margarida; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. Design, Synthesis and Biological Evaluation Towards Aromatase of C-4 Derivatives of Formestane and 5alpha-Androst-3-en-17-one,XXI International Symposium on Medicinal Chemistry,Brussels,2010 (Poster).
39. Varela, Carla L; Roleira, Fernanda M. F; Correia-da-Silva, Georgina; Cepa, Margarida; Dias, Ana; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. Androstenes vs Epoxyandrostanes. The role of the Planarity of the A-Ring in Aromatase Inhibition. A Structure-Activity Study,Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies,Barcelona,2009 (Poster).
40. Roleira, Fernanda M. F; Sintra, T.; Varela, Carla L; Correia-da-Silva, Georgina; Cepa, Margarida; Dias, Ana; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. The Effect of C-3 Stereochemistry in the Aromatase Inhibitory Activity of 3- Hydroxy-4-Androstenes. A Structure-Activity Study,Frontiers in Medicinal Chemistry: Emerging T argets, Novel Candidates and Innovative Strategies,Barcelona,2009 (Poster).
41. Tavares-da-Silva, Elisiário J; Cepa, Margarida; Correia-da-Silva, Georgina; Teixeira, Natércia; Varela, Carla L; Roleira, Fernanda M. Structure-Activity Relationships on 4-Androstenes and 5alpha-Androstan-4-ones as Aromatase Inhibitors,XX International Symposium on Medicinal Chemistry,Vienna,2008 (Poster).
42. Tavares-da-Silva, Elisiário J; Cepa, Margarida; Correia-da-Silva, Georgina; Teixeira, Natércia; Varela, Carla L; Roleira, Fernanda M. F. Structure-Based Design, Synthesis, and Biological Evaluation of New Steroids Aromatase Inhibitors,Symposium on Advances on Synthetic and Medicinal Chemistry,Saint Petersburg,2007 (Poster).
43. Varela, Carla L. EQOFAR,Environmental Health Seminar,2006 (Poster).
44. Cruz, Filipa; Matos, Cyntia; Varela, Carla L; Moreno, Mª J. S. M. ECODYNAMIC – Environmental Education for Adults,Environmental Health Seminar,2006 (Poster).
45. Varela, Carla L; Caçador, Catarina; Moreno, Mª J. S. M. Separation and collection of urban solid waste: habits and attitudes,I Educational Forum of Organic Chemistry in Pharmaceutical Sciences,2005 (Simpósio).
46. Cruz, Filipa; Matos, Cyntia; Varela, Carla L; Moreno, Mª J. S. M. Ecodynamic Program – Environmental Education for Adults,I Educational Forum of Organic Chemistry in Pharmaceutical Sciences,2005 (Simpósio).

Curso de curta duração lecionado
Taught short course
1. Varela, Carla L. Synthesis of Aspirin, 2014 (Extensão), promovido por Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, University of Coimbra; 28 March 2014 (Escola 2,3/S Dr. Manuel Ribeiro Ferreira – Agrupamento de Escolas de Alavaiázere).
2. Varela, Carla L. Synthesis of aspirin, 2014 (Extensão), promovido por Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, University of Coimbra; 5 June 2014 (Escola Básica Grão Vasco do Agrupamento de Escolas Zona Urbana de Viseu).
3. Varela, Carla L. “Como preparar o Paracetamol?” - Universidade de Verão, Faculdade de Farmácia, Universidade de Coimbra, 2014 (Extensão).
4. Varela, Carla L. Synthesis of Aspirin - Summer University, at the Faculty of Pharmacy, University of Coimbra, 2013 (Extensão), promovido por Faculty of Pharmacy, University of Coimbra.Tipo de participação: Outra.
5. Varela, Carla L. Synthesis of Aspirin, 2013 (Extensão), promovido por Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, University of Coimbra; 3 April 2013 (Escola Secundária de Ourém).
6. Varela, Carla L. Synthesis of Aspirin, 2013 (Extensão), promovido por Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, University of Coimbra; 14 March 2013 (Escola José Falcão, Coimbra).
7. Varela, Carla L. Synthesis of Aspirin - Summer University, at the Faculty of Pharmacy, University of Coimbra, 2010 (Extensão), promovido por Faculty of Pharmacy, University of Coimbra.
8. Varela, Carla L. Public Health and Environment – 3E’s Program, 2006 (Extensão), promovido por Portuguese Pharmacists Association, regional section of Coimbra; 6 March 2006.Tipo de participação: Outra.
9. Varela, Carla L. Public Health and Environment – 3E’s Program, 2006 (Extensão), promovido por Portuguese Pharmacists Association, regional section of Coimbra; 12 January 2006.
10. Varela, Carla L. Public Health and Environment – 3E’s Program, 2006 (Extensão), promovido por Portuguese Pharmacists Association, regional section of Porto; 19 May 2006.Tipo de participação: Outra.

Organização de evento
Event organization
1. Varela, Carla L. 2nd Iberic Meeting on Medicinal Chemistry - G Protein-Coupled Receptors an Enzymes in Drug Discovery,2011 (Encontro).
2. Varela, Carla L. 1st Iberic Meeting on Medicinal Chemistry – Anticancer Agents,2007 (Encontro).
3. Varela, Carla L. I Educational Forum of Organic Chemistry in Pharmaceutical Sciences,2005 (Encontro).
4. Varela, Carla L. EQOFAR – Estudantes de Química Orgânica – Acção/Reacção (Students of organic chemistry – action/reaction), of the Faculty of Pharmacy, University of Coimbra,2004 (Outro).





Dados Complementares (Additional data)


Orientações
Orientations


Trabalho de conclusão de curso de Bacharelato/Licenciatura
Bachelor/Licenciate degree conclusion work
Concluídas
Completed
1. Enza Lo Giudice, Design, synthesis and biochemical studies of 7a-vinyl derivatives of androstenedione as aromatase inhibitors, 2013. (Co-orientador).
2. Valeria Muliello , Design, synthesis and biochemical studies of derivatives of 4-androstene-17ß-carboxylic acid as 5a-reductase inhibitors, 2013. (Co-orientador).
3. Valentina Valastro , Synthesis of the analogue 3,4-cyclopropan from the aromatase inhibitor 5a-androst-3-ene-17-one, 2011. (Co-orientador).
4. Michael Jefferson Amorim de Oliveira , Design, synthesis and evaluation of amebicide activity of nitazoxanide analogs, 2011. (Co-orientador).


Iniciação científica
Scientific initiation
Concluídas
Completed
1. Iti-Ingris Sei, Synthesis and purification of two amides: hexylamide of 3,4,5-trihydroxycinnamic acid and of hydrocaffeic acid., 2014. (Co-orientador).
2. Annela Toom , Synthesis and purification of two amides: hexylamide of 3,4,5-trihydroxycinnamic acid and of hydrocaffeic acid., 2014. (Co-orientador).
3. Mónica Morera , Follow up and participation within the ongoing PhD activities “Design, synthesis and structure-activity studies of steroidal inhibitors of aromatase and 5a-reductase as anti-tumors”, 2012. (Co-orientador).
4. Alina Grecu, Follow up and participation within the ongoing PhD activities “Design, synthesis and structure-activity studies of steroidal inhibitors of aromatase and 5a-reductase as anti-tumors”, 2012. (Co-orientador).
5. Alexandra Tolda Pinto, Design, synthesis and biochemical studies of 4,5-epoxy- and 4,5-cyclopropan-3-desoxyandrostan-17-one derivatives as aromatase inhibitors, 2011. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador).
6. Ana Isabel Martins , Design, synthesis and biochemical studies of 3-desoxy analogues of ¿6-androstenedione and its 7a-allyl derivatives as aromatase inhibitors, 2011. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador).
7. Luca Cariate , Synthesis of the hexylamide from caffeic acid, 2011. (Co-orientador).
8. Ola Mejza Aleksandra , Follow up and participation within the ongoing PhD activities “Design, synthesis and structure-activity studies of steroidal inhibitors of aromatase and 5a-reductase as anti-tumors”, 2011. (Co-orientador).
9. Rita Martins , Synthesis of potential inhibitors of 5a-reductase, 2010. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador).
10. David Preece , Follow up and participation within the ongoing PhD activities “Design, synthesis and structure-activity studies of steroidal inhibitors of aromatase and 5a-reductase as anti-tumors”, 2010. (Co-orientador).
11. Carlos André Araújo Duarte Monteiro , Synthesis of potential inhibitors of 5a-reductase, 2010. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador).
12. Joana Baptista , Synthesis and characterization of phenolic amides with potential activity in breast cancer, 2009. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador).
13. Cátia Martins Tomé, Synthesis of amides with potential activity against dengue disease, 2009. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador).
Em curso
Ongoing
1. Pedro Manuel Duarte Ribeiro, Design, synthesis and biochemical studies of 17-carboxamyde derivatives of formestane as aromatase inhibitors, 2014. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador).
2. Pedro Manuel Duarte Ribeiro , Design, synthesis and biochemical studies of 17-carboxamyde derivatives of formestane as aromatase inhibitors, 2013. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador).
3. Daniela Filipa Felício Marques , Design, synthesis and biochemical studies of 7a-vinyl derivatives of androstenedione as aromatase inhibitors, 2012. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador).
4. Pedro Manuel Duarte Ribeiro , Design, synthesis and biochemical studies of 17-carboxamyde derivatives of formestane as aromatase inhibitors, 2012. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador).


Participação em eventos
Event participation
Outro tipo de participação
Other kind of participation
1. 22nd Conference on Isoprenoids, 2014 (Congresso).
Nome do evento: 22nd Conference on Isoprenoids; Cidade do evento: Prague / Czech Republic.
2. IV CEF Conference 2013, 2013 (Conferência).
Nome do evento: IV CEF Conference.
3. 5th BBBB International Conference, 2013 (Congresso).
Nome do evento: 5th BBBB International Conference.
4. 2nd Workshop on Medicinal Chemistry Drug Discovery and Development: Understanding the R&D Process, 2013 (Workshop).
5. European School of Medicinal Chemistry – XXXIII Advanced Course of Medicinal Chemistry and “E. Duranti” National Seminar for PhD Students, 2013 (Outra).
6. Workshop in Bioinformatics, 2012 (Workshop).
7. XXII International Symposium on Medicinal Chemistry, 2012 (Simpósio).
8. Conference CEF 2012, 2012 (Conferência).
9. 2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery, 2011 (Encontro).
10. Frontiers in Medicinal Chemistry Meeting, 2011 (Encontro).
11. Conference CEF 2011, 2011 (Conferência).
12. 4th BBBB – Bled International Conference on Pharmaceutical Sciences, 2011 (Conferência).
13. XXI International Symposium on Medicinal Chemistry, 2010 (Simpósio).
14. 10th International Aromatase Meeting, 2010 (Encontro).
15. Conference CEF 2010, 2010 (Conferência).
16. Course of administration of vaccines, 2008 (Outra).
17. 1st Iberic Meeting on Medicinal Chemistry – Anticancer Agents, 2007 (Encontro).
18. XII Annual Symposium: Paediatrics and Geriatrics – the role of the pharmacist, 2006 (Simpósio).
19. Annual Scientific Conference: Clinical Trial Management – Global Strategies for a Global World, 2006 (Conferência).
20. Homogeneous Catalysis Coimbra Course, 2004 (Outra).
21. Symposium: Generics, towards a future without doubts, 2002 (Simpósio).








Indicadores de produção (Production indicators)

Total
Produção científica
Scientific production
24

Artigos científicos em revistas
Papers in periodics
9
Com arbitragem científica
With scientific refereeing
1
Sem arbitragem científica
Without scientific refereeing
8
Trabalhos em eventos
Papers in conference proceedings
15
Com arbitragem científica
With scientific refereeing
1
Sem arbitragem científica
Without scientific refereeing
14

Total
Produção técnica
Technical production
60

Outros tipos de produção técnica
Other technical production
60

Total
Dados complementares
(Additional data)
42

Orientações
Orientations
21
Participação em Eventos
Event participation
21


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