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HHpred - Homology detection & structure prediction by HMM-HMM comparison

Search with pancreatitis induced protein PIP49.
or upload a local file
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Select HMM databases
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MSA Generation Method
 HHblits  Psiblast 
Score secondary structure
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Alignment mode
 local  global 
 (leave empty for automatic creation)
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Söding J, Biegert A, Lupas AN (2005) The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res 33 (suppl 2), W244-W248.

Söding J (2005) Protein homology detection by HMM-HMM comparison. Bioinformatics 21: 951-960.

Biegert A, Mayer C, Remmert M, Söding J, Lupas AN (2006) The MPI Bioinformatics Toolkit for protein sequence analysis. Nucleic Acids Res 34 (suppl 2), W335-W339.

Hildebrand A, Remmert A, Biegert A, Söding J (2009) Fast and accurate automatic structure prediction with HHpred. Proteins 77 (S9), 128-132.

Meier A, Söding J (2015) Automatic Prediction of Protein 3D Structures by Probabilistic Multi-template Homology Modeling. PLoS Comput Biol 11 (10), e1004343.

Remmert M, Biegert A, Hauser A, Söding J (2012) HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment. Nature Methods 9 (2), 173-175.