Ines Biscaia de Andrade Barbosa
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                        												Data da última atualização
                        												»Last update
                        												:
                        												19/09/2013 | 
                
              
            
 Dados pessoais (Personal data)  
            
               
                  
                     Nome completo
                        						 Full name | 
                     Ines Biscaia de Andrade Barbosa | 
                   
                  
                     Nome em citações bibliográficas
                        							 Quoting name | 
                     Barbosa, Ines Biscaia de Andrade | 
                   
                  
                     Domínio científico de atuação
                        						 Scientific domain | 
                     Ciências Naturais-Ciências Biológicas. Ciências Médicas-Ciências da Saúde. Ciências Exactas-Outras Ciências Exactas. Humanidades-Línguas e Literaturas.
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                     Endereço profissional
                        						 Professional address | 
                     Universidade de Coimbra Centro de Neurociências de Coimbra Largo Marques de Pombal Coimbra 3004--517 Coimbra Portugal Telefone: (+351)239855760 Fax: (+351)239853409 Correio electrónico: ines.b.a.barbosa@gmail.com | 
                   
                
               
                  
                     Sexo
                        							 Gender | 
                     Feminino»Female | 
                   
                 
 
                  			Graus Académicos
                  			 (Academic Degrees) 
            
               
                  
                     | 2003-2008 | 
                     Licenciatura Licentiate degree | 
                   
                  
                     Biologia
                        							(5 anos » years)
                        						.
                        					 Universidade de Coimbra,
                        			Portugal.
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 Formação complementar ( studies) 
            
               
                  
                     | 2012-2012 | 
                     Curso de curta duração Short course | 
                   
                  
                     Course on Statistical analysis with SPSS.
                        					 Curva de Gauss - Estudos de Formação e Consultoria ,
                        			Portugal.
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                     | 2011-2011 | 
                     Curso de curta duração Short course | 
                   
                  
                     Training School in the Experimental Design and Statistical Analysis.
                        					 FRAME,
                        			Reino Unido.
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                     | 2011-2011 | 
                     Curso de curta duração Short course | 
                   
                  
                     Course of image analysis for life sciences, INFAIMON.
                        					 Universidade de Coimbra,
                        			Portugal.
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                     | 2004-2011 | 
                     Outros Others | 
                   
                  
                     Certificate of Proficiency in English, ESOL examinations. British Council,
                        			Portugal.
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                     | 2009-2009 | 
                     Curso de curta duração Short course | 
                   
                  
                     Real Time PCR: Principles, Chemistry and Gene Expression Analysis and PMC .
                        					 Bio-Rad,
                        			Portugal.
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                     | 2008-2008 | 
                     Curso de curta duração Short course | 
                   
                  
                     Successful Approaches to Effective Real-Time RT-PCR.
                        					 Bio-Rad,
                        			Portugal.
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                     | 2006-2006 | 
                     Curso de curta duração Short course | 
                   
                  
                     Regenerative Biology, in ENEB.
                        					 Universidade do Porto,
                        			Portugal.
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                     | 2004-2004 | 
                     Curso de curta duração Short course | 
                   
                  
                     Brain Cell Culture, in ENEB.
                        					 Universidade de Coimbra,
                        			Portugal.
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                     | 2003-2003 | 
                     Curso de curta duração Short course | 
                   
                  
                     Plant Biotechnology, in CNEB.
                        					 Universidade de Évora,
                        			Portugal.
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 Vínculos profissionais
                  				 (Professional Positions) 
            
               
               
                  
                     | Mar/2009-Actual | 
                     Outra Situação | 
                   
                 
 Projetos de Investigação (Research projects)  
            
               
                  
                     Participação como Desenvolvimento técnico Participation as Technical developer | 
                   
                
                  
                     2010-2013 Clarification of the mitochondrial role in the cardiotoxicity of doxorubicin using a whole heart perfusion system - impact
                        of different doxorubicin treatment regimens
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                     Referência do projeto»Project reference: PTDC/SAU/OSM/104731/2008. Parceiro(s)»Partners:
                        							Universidade de Coimbra; University of Minnesota Duluth.  Financiador(es)»Funding:
                        							Fundação para a Ciência e a Tecnologia. 
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                     Outro Tipo de Participação Other kind of participation | 
                   
                
                  
                     2012-2014 Role of mitochondrial p66Shc in drug-induced mitochondrial toxicity memory | 
                   
                
               
                  
                     Referência do projeto»Project reference: PTDC/SAU-TOX/117912/2010. Parceiro(s)»Partners:
                        							Nencki Institute of Experimental Biology.  Financiador(es)»Funding:
                        							Fundação para a Ciência e a Tecnologia. 
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 Línguas (Languages) 
            
               
                  
                     Compreende Understandig | 
                     Português (Bem), Inglês (Bem), Francês (Razoavelmente), Espanhol (Razoavelmente). | 
                   
                  
                     Fala Speaking | 
                     Português (Bem), Inglês (Bem), Francês (Razoavelmente), Espanhol (Razoavelmente). | 
                   
                  
                     Lê Reading | 
                     Português (Bem), Inglês (Bem), Francês (Razoavelmente), Espanhol (Razoavelmente). | 
                   
                  
                     Escreve Writing | 
                     Português  (Bem), Inglês  (Bem), Francês (Razoavelmente), Espanhol (Razoavelmente). | 
                   
                 
 Prémios e títulos (Awards Prizes, and Honours) 
            
               
                  
                     | 2007 | 
                     Annual prize for the 3% best students of University of Coimbra,
                        					Universidade de Coimbra.
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                     | 2008 | 
                     Doctoral Scholarship,
                        					Foundation for Science and Technology (FCT).
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                     | 2010 | 
                     Student Travel Grant,
                        					Association for International Cancer Research (AICR).
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                  											Produção científica, técnica e artística/cultural
                  											 (Scientific, technical and artistical/cultural
                     													production) 
            
               
                  
                     Artigos em revistas sem arbitragem científica Papers in periodics without scientific refereeing | 
                   
                
               
                  
                     | 1. | 
                      Barbosa, Inês A; Machado, Nuno G; Skildum, Andrew J; Scott, Patricia M; Oliveira, Paulo J.  2012. "Mitochondrial remodeling in cancer metabolism and survival: Potential for new therapies", Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1826, 1: 238 - 254.
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                     | 2. | 
                     V. Diogo, C; G. Machado, N; A. Barbosa, I; L. Serafim, T; Burgeiro, Ana; J. Oliveira, P.  2011. "Berberine as a Promising Safe Anti-Cancer Agent- Is there a Role for Mitochondria?", Current Drug Targets 12, 6: 850 - 859.
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                     | 3. | 
                     Diogo, Cátia V; Félix, Luís; Vilela, Sérgio; Burgeiro, Ana; Barbosa, Inês A; Carvalho, Maria J; Oliveira, Paulo J; Peixoto, Francisco P.  2009. "Mitochondrial toxicity of the phyotochemicals daphnetoxin and daphnoretin – Relevance for possible anti-cancer application", Toxicology in Vitro 23, 5: 772 - 779.
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                     Apresentação oral de trabalho Oral work presentation | 
                   
                
               
                  
                     | 1. | 
                     Barbosa, Ines B. A; Scott, Patricia M; Oliveira, Paulo J. Regulation of mitochondrial function and cell death/autophagy by the tumor necrosis factor receptor-associated protein 1 (trap1)
                        in lung cancer cells.,47th Annual Scientific Meeting of the European Society for Clinical Investigation,Albufeira,2013 (Comunicação). | 
                   
                
               
                  
                     Curso de curta duração lecionado Taught short course | 
                   
                
               
                  
                     | 1. | 
                     Barbosa, Ines B. A; Pereira, Sandro. Energy production in cell, 2013 (Extensão). Duração: 3 horas., Tipo de participação: Docente. | 
                   
                
               
                  
                     | 2. | 
                     Barbosa, Ines B. A; V. Diogo, C; Machado, Nuno G; Mesquita, Katia. Cell death in yeast, 2013 (Extensão). Duração: 3 horas., Tipo de participação: Docente. | 
                   
                
               
                  
                     | 3. | 
                     Barbosa, Ines B. A. Role of mitochondrial TRAP-1 and PINK in cancer tolerance to chemotherapeutics, 2011 (Extensão), promovido por BEB - Doctoral Programme in Experimental Biology and Biomedicine. Duração: 1 horas., Tipo de participação: Docente. | 
                   
                
               
                  
                     Organização de evento Event organization | 
                   
                
               
                  
                     | 1. | 
                     Barbosa, Ines B. A. 47th Annual Scientific Meeting of the ESCI – “Mitochondrial Physiology: from basic research to the clinic”,2013 (Encontro). | 
                   
                
               
                  
                     | 2. | 
                     Barbosa, Ines B. A. International Courses on • Toxicology 2010 – “Survival as a Matter of Fat”,2010 (Congresso). | 
                   
                
               
                  
                     | 3. | 
                     Barbosa, Ines B. A. International Courses on Toxicology 2009 – “Mitochondria Between Life and Death”,2009 (Congresso). | 
                   
                
               
                  
                     | 4. | 
                     Barbosa, Ines B. A. 10th Luso-Spanish Meeting of Herpetology,2008 (Encontro). | 
                   
                 
 Dados Complementares (Additional data) 
            
               
                  
                     Outros Trabalhos Other production | 
                   
                
               
                  
                     | 1. | 
                     Barbosa, Ines B. A. Science in the holidays Program, 2012.  High-school students tutoring
                           Responsible for introducing research work and development of small project in the lab with high-school students. | 
                   
                
               
                  
                     | 2. | 
                     Barbosa, Ines B. A. Science in the holidays Program, 2011.  High-school students tutoring Responsible for introducing research work and development of small project in the lab with high-school
                           students. | 
                   
                
                  
                     Participação em eventos Event participation | 
                   
                
               
                  
                     Outro tipo de participação Other kind of participation | 
                   
                
               
                  
                     | 1. | 
                     Regulation of mitochondrial function and cell death/autophagy by the tumor necrosis factor receptor-associated protein 1 (trap1)
                        in lung cancer cells., 2013 (Congresso).  Nome do evento: ESCI 2013 - 47th Annual Scientific Meeting of the European Society for Clinical Investigation; Cidade do evento: Albufeira. Oral Presentation. | 
                   
                
               
                  
                     | 2. | 
                     p66shc involvement in altered mitochondrial oxidant production in trap1 overexpressing lung cancer cells., 2012 (Congresso).  Nome do evento: 3rd World Congress on Targeting Mitochondria; Cidade do evento: Berlin. Poster. | 
                   
                
               
                  
                     | 3. | 
                     Barcelona BioMed Conferences “Mitochondrial Autophagy”, 2011 (Congresso).  | 
                   
                
               
                  
                     | 4. | 
                     BSCR Autumn Meeting 2011 “Mitochondria in Cardiovascular Disease: Emerging Concepts and Novel Therapeutic Targets”, 2011 (Encontro).  Nome do evento: BSCR Autumn Meeting 2011 “Mitochondria in Cardiovascular Disease: Emerging Concepts and Novel Therapeutic Targets”. | 
                   
                
               
                  
                     | 5. | 
                     Possible anti-cancer application of the phytochemicals daphnetoxin and daphnoretin – relevance for mitochondrial toxicity., 2010 (Congresso).  Nome do evento: 44th Annual Scientific Meeting of the European Society for Clinical Research; Cidade do evento: Bari. Poster. | 
                   
                
               
                  
                     | 6. | 
                     Role of trap1/pink1 interaction in oncogenic development, 2010 (Conferência).  Nome do evento: AICR 30th Anniversary Conference “Today’s Research - Tomorrow’s Therapies; Cidade do evento: St Andrews. Poster. | 
                   
                
               
                  
                     | 7. | 
                     Mitochondrial toxicity of the phyotochemicals daphnetoxin and daphnoretin - relevance for possible anti-cancer application., 2009 (Congresso).  Nome do evento: nternational Courses on Toxicology 2009 - "Mitochondria: Between Life and Dead"; Cidade do evento: Coimbra. Poster. | 
                   
                
               
                  
                     | 8. | 
                     39th Annual Meeting of the Portuguese Pharmacological Society, 2008 (Encontro). 
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                     | 9. | 
                     International Courses on Toxicology “Stem Cells as a Tool in Toxicology", 2007 (Congresso).  | 
                   
                
               
                  
                     | 10. | 
                     38th Annual Meeting of the Portuguese Pharma- cological Society, 2007 (Congresso).  | 
                   
                
               
                  
                     | 11. | 
                     Cytotox- icity of daphnoretin on mouse k1735-m2 melanoma cells - are mitochondrial effects relevant?, 2007 (Congresso).  Nome do evento: XXXVIII Annual Meeting of the Portuguese Society of Phar- macology / XXV Meeting of Clinical Pharmacology / VII Toxicology
                        Meeting; Cidade do evento: Coimbra. Oral Presentation. | 
                   
                
               
                  
                     | 12. | 
                     Inefficacy of daphnetoxin as an effective anti-proliferative agent on a metastatic mouse melanoma cell line., 2007 (Congresso).  Nome do evento: XXXVIII Annual Meeting of the Portuguese Society of Pharmacology / XXV Meeting of Clinical Pharmacology / VII Toxicology Meeting; Cidade do evento: Coimbra. Oral Presentation. | 
                   
                
               
                  
                     | 13. | 
                     10th Symposium of Biology Students in Europe, 2006 (Simpósio).
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                     | 14. | 
                     A day of forensic anthropology, 2005 (Seminário). 
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                  											Indicadores de produção
                  											 (Production indicators) 
            Outras informações relevantes 
            
               
                  
                     Specialization
                        
                        Cancer/Oncology: Processing human paraffin embedded biopsies by histology, analysis and pathological identification.  Knowledge
                        of signalling and cell death pathways in cancer cell lines. 
                        Cell Biology: Experience with cell culture (cell lines) of human and non-human origin and its handling such as freeze/thawing,
                        maintenance, differentiation and transfection.  Knowledge and experience with co-immunoprecipitation, western blotting,
                        hematoxylin eosin staining and immunohistochemistry techniques. 
                        Molecular Biology: Experience with cellular transfection techniques and gene silencing either using siRNA or viral vectors. 
                        Knowledge in PCR gene amplification and qRT-PCR gene expression, gene sequencing assay. 
                        Bioenergetics: Evaluation of mitochondrial function (ex.  oxygen consumption, membrane potential and ROS production) in
                        vivo or pos-fixation either by microscopy or flow cytometer. 
                        Toxicology: Toxicological mechanisms of anti-tumor compounds in mitochondrial dysfunction (cell lines). 
                        Cardiovascular: Use of Langendorf heart and TTC staining to access hemodynamic alterations and infarct size during ischemia-reperfusion
                        Experimental Biology: Handling and experimentation of laboratory animals (rats)
                        
                        Current research interests
                        
                        Heat shock proteins: HSPs role in cancer development, namely TRAP1 a HSP90 family member.  Role of TRAP1 in the development
                        of a chemoresistant phenotype by tumor cells. 
                        Cell death pathways: Apoptosis programed cell death pathways in tumor versus normal cells.  Autophagy pathways in normal
                        and tumor cells.  Autophagy and tumor cell progression and death promotion. 
                        Cancer metabolism: Role of mitochondria and its morphological and metabolic changes during tumor development. 
                        Autophagy: Autophagy and its role in mitochondrial quality control and cell death. 
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