Ines Biscaia de Andrade Barbosa
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Data da última atualização
»Last update
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19/09/2013 |
Dados pessoais (Personal data)
Nome completo
Full name |
Ines Biscaia de Andrade Barbosa |
Nome em citações bibliográficas
Quoting name |
Barbosa, Ines Biscaia de Andrade |
Domínio científico de atuação
Scientific domain |
Ciências Naturais-Ciências Biológicas.
Ciências Médicas-Ciências da Saúde.
Ciências Exactas-Outras Ciências Exactas.
Humanidades-Línguas e Literaturas.
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Endereço profissional
Professional address |
Universidade de Coimbra
Centro de Neurociências de Coimbra
Largo Marques de Pombal
Coimbra
3004--517 Coimbra
Portugal
Telefone: (+351)239855760
Fax: (+351)239853409
Correio electrónico: ines.b.a.barbosa@gmail.com |
Sexo
Gender |
Feminino»Female |
Graus Académicos
(Academic Degrees)
| 2003-2008 |
Licenciatura
Licentiate degree |
Biologia
(5 anos » years)
.
Universidade de Coimbra,
Portugal.
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Formação complementar ( studies)
| 2012-2012 |
Curso de curta duração
Short course |
Course on Statistical analysis with SPSS.
Curva de Gauss - Estudos de Formação e Consultoria ,
Portugal.
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| 2011-2011 |
Curso de curta duração
Short course |
Training School in the Experimental Design and Statistical Analysis.
FRAME,
Reino Unido.
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| 2011-2011 |
Curso de curta duração
Short course |
Course of image analysis for life sciences, INFAIMON.
Universidade de Coimbra,
Portugal.
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| 2004-2011 |
Outros
Others |
Certificate of Proficiency in English, ESOL examinations.
British Council,
Portugal.
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| 2009-2009 |
Curso de curta duração
Short course |
Real Time PCR: Principles, Chemistry and Gene Expression Analysis and PMC .
Bio-Rad,
Portugal.
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| 2008-2008 |
Curso de curta duração
Short course |
Successful Approaches to Effective Real-Time RT-PCR.
Bio-Rad,
Portugal.
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| 2006-2006 |
Curso de curta duração
Short course |
Regenerative Biology, in ENEB.
Universidade do Porto,
Portugal.
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| 2004-2004 |
Curso de curta duração
Short course |
Brain Cell Culture, in ENEB.
Universidade de Coimbra,
Portugal.
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| 2003-2003 |
Curso de curta duração
Short course |
Plant Biotechnology, in CNEB.
Universidade de Évora,
Portugal.
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Vínculos profissionais
(Professional Positions)
| Mar/2009-Actual |
Outra Situação |
Projetos de Investigação (Research projects)
Participação como Desenvolvimento técnico
Participation as Technical developer |
2010-2013
Clarification of the mitochondrial role in the cardiotoxicity of doxorubicin using a whole heart perfusion system - impact
of different doxorubicin treatment regimens
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Referência do projeto»Project reference: PTDC/SAU/OSM/104731/2008.
Parceiro(s)»Partners:
Universidade de Coimbra; University of Minnesota Duluth.
Financiador(es)»Funding:
Fundação para a Ciência e a Tecnologia.
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Outro Tipo de Participação
Other kind of participation |
2012-2014
Role of mitochondrial p66Shc in drug-induced mitochondrial toxicity memory |
Referência do projeto»Project reference: PTDC/SAU-TOX/117912/2010.
Parceiro(s)»Partners:
Nencki Institute of Experimental Biology.
Financiador(es)»Funding:
Fundação para a Ciência e a Tecnologia.
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Línguas (Languages)
Compreende
Understandig |
Português (Bem), Inglês (Bem), Francês (Razoavelmente), Espanhol (Razoavelmente). |
Fala
Speaking |
Português (Bem), Inglês (Bem), Francês (Razoavelmente), Espanhol (Razoavelmente). |
Lê
Reading |
Português (Bem), Inglês (Bem), Francês (Razoavelmente), Espanhol (Razoavelmente). |
Escreve
Writing |
Português (Bem), Inglês (Bem), Francês (Razoavelmente), Espanhol (Razoavelmente). |
Prémios e títulos (Awards Prizes, and Honours)
| 2007 |
Annual prize for the 3% best students of University of Coimbra,
Universidade de Coimbra.
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| 2008 |
Doctoral Scholarship,
Foundation for Science and Technology (FCT).
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| 2010 |
Student Travel Grant,
Association for International Cancer Research (AICR).
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Produção científica, técnica e artística/cultural
(Scientific, technical and artistical/cultural
production)
Artigos em revistas sem arbitragem científica
Papers in periodics without scientific refereeing |
| 1. |
 Barbosa, Inês A; Machado, Nuno G; Skildum, Andrew J; Scott, Patricia M; Oliveira, Paulo J. 2012. "Mitochondrial remodeling in cancer metabolism and survival: Potential for new therapies", Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1826, 1: 238 - 254.
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| 2. |
V. Diogo, C; G. Machado, N; A. Barbosa, I; L. Serafim, T; Burgeiro, Ana; J. Oliveira, P. 2011. "Berberine as a Promising Safe Anti-Cancer Agent- Is there a Role for Mitochondria?", Current Drug Targets 12, 6: 850 - 859.
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| 3. |
Diogo, Cátia V; Félix, Luís; Vilela, Sérgio; Burgeiro, Ana; Barbosa, Inês A; Carvalho, Maria J; Oliveira, Paulo J; Peixoto, Francisco P. 2009. "Mitochondrial toxicity of the phyotochemicals daphnetoxin and daphnoretin – Relevance for possible anti-cancer application", Toxicology in Vitro 23, 5: 772 - 779.
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Apresentação oral de trabalho
Oral work presentation |
| 1. |
Barbosa, Ines B. A; Scott, Patricia M; Oliveira, Paulo J. Regulation of mitochondrial function and cell death/autophagy by the tumor necrosis factor receptor-associated protein 1 (trap1)
in lung cancer cells.,47th Annual Scientific Meeting of the European Society for Clinical Investigation,Albufeira,2013 (Comunicação). |
Curso de curta duração lecionado
Taught short course |
| 1. |
Barbosa, Ines B. A; Pereira, Sandro. Energy production in cell, 2013 (Extensão).
Duração: 3 horas., Tipo de participação: Docente. |
| 2. |
Barbosa, Ines B. A; V. Diogo, C; Machado, Nuno G; Mesquita, Katia. Cell death in yeast, 2013 (Extensão).
Duração: 3 horas., Tipo de participação: Docente. |
| 3. |
Barbosa, Ines B. A. Role of mitochondrial TRAP-1 and PINK in cancer tolerance to chemotherapeutics, 2011 (Extensão), promovido por BEB - Doctoral Programme in Experimental Biology and Biomedicine.
Duração: 1 horas., Tipo de participação: Docente. |
Organização de evento
Event organization |
| 1. |
Barbosa, Ines B. A. 47th Annual Scientific Meeting of the ESCI – “Mitochondrial Physiology: from basic research to the clinic”,2013 (Encontro). |
| 2. |
Barbosa, Ines B. A. International Courses on • Toxicology 2010 – “Survival as a Matter of Fat”,2010 (Congresso). |
| 3. |
Barbosa, Ines B. A. International Courses on Toxicology 2009 – “Mitochondria Between Life and Death”,2009 (Congresso). |
| 4. |
Barbosa, Ines B. A. 10th Luso-Spanish Meeting of Herpetology,2008 (Encontro). |
Dados Complementares (Additional data)
Outros Trabalhos
Other production |
| 1. |
Barbosa, Ines B. A. Science in the holidays Program, 2012.
High-school students tutoring
Responsible for introducing research work and development of small project in the lab with high-school students. |
| 2. |
Barbosa, Ines B. A. Science in the holidays Program, 2011.
High-school students tutoring Responsible for introducing research work and development of small project in the lab with high-school
students. |
Participação em eventos
Event participation |
Outro tipo de participação
Other kind of participation |
| 1. |
Regulation of mitochondrial function and cell death/autophagy by the tumor necrosis factor receptor-associated protein 1 (trap1)
in lung cancer cells., 2013 (Congresso).
Nome do evento: ESCI 2013 - 47th Annual Scientific Meeting of the European Society for Clinical Investigation; Cidade do evento: Albufeira.
Oral Presentation. |
| 2. |
p66shc involvement in altered mitochondrial oxidant production in trap1 overexpressing lung cancer cells., 2012 (Congresso).
Nome do evento: 3rd World Congress on Targeting Mitochondria; Cidade do evento: Berlin.
Poster. |
| 3. |
Barcelona BioMed Conferences “Mitochondrial Autophagy”, 2011 (Congresso). |
| 4. |
BSCR Autumn Meeting 2011 “Mitochondria in Cardiovascular Disease: Emerging Concepts and Novel Therapeutic Targets”, 2011 (Encontro).
Nome do evento: BSCR Autumn Meeting 2011 “Mitochondria in Cardiovascular Disease: Emerging Concepts and Novel Therapeutic Targets”. |
| 5. |
Possible anti-cancer application of the phytochemicals daphnetoxin and daphnoretin – relevance for mitochondrial toxicity., 2010 (Congresso).
Nome do evento: 44th Annual Scientific Meeting of the European Society for Clinical Research; Cidade do evento: Bari.
Poster. |
| 6. |
Role of trap1/pink1 interaction in oncogenic development, 2010 (Conferência).
Nome do evento: AICR 30th Anniversary Conference “Today’s Research - Tomorrow’s Therapies; Cidade do evento: St Andrews.
Poster. |
| 7. |
Mitochondrial toxicity of the phyotochemicals daphnetoxin and daphnoretin - relevance for possible anti-cancer application., 2009 (Congresso).
Nome do evento: nternational Courses on Toxicology 2009 - "Mitochondria: Between Life and Dead"; Cidade do evento: Coimbra.
Poster. |
| 8. |
39th Annual Meeting of the Portuguese Pharmacological Society, 2008 (Encontro).
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| 9. |
International Courses on Toxicology “Stem Cells as a Tool in Toxicology", 2007 (Congresso). |
| 10. |
38th Annual Meeting of the Portuguese Pharma- cological Society, 2007 (Congresso). |
| 11. |
Cytotox- icity of daphnoretin on mouse k1735-m2 melanoma cells - are mitochondrial effects relevant?, 2007 (Congresso).
Nome do evento: XXXVIII Annual Meeting of the Portuguese Society of Phar- macology / XXV Meeting of Clinical Pharmacology / VII Toxicology
Meeting; Cidade do evento: Coimbra.
Oral Presentation. |
| 12. |
Inefficacy of daphnetoxin as an effective anti-proliferative agent on a metastatic mouse melanoma cell line., 2007 (Congresso).
Nome do evento: XXXVIII Annual Meeting of the Portuguese Society of Pharmacology / XXV Meeting of Clinical Pharmacology / VII Toxicology Meeting; Cidade do evento: Coimbra.
Oral Presentation. |
| 13. |
10th Symposium of Biology Students in Europe, 2006 (Simpósio).
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| 14. |
A day of forensic anthropology, 2005 (Seminário).
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Indicadores de produção
(Production indicators)
Outras informações relevantes
Specialization
Cancer/Oncology: Processing human paraffin embedded biopsies by histology, analysis and pathological identification.
Knowledge
of signalling and cell death pathways in cancer cell lines.
Cell Biology: Experience with cell culture (cell lines) of human and non-human origin and its handling such as freeze/thawing,
maintenance, differentiation and transfection.
Knowledge and experience with co-immunoprecipitation, western blotting,
hematoxylin eosin staining and immunohistochemistry techniques.
Molecular Biology: Experience with cellular transfection techniques and gene silencing either using siRNA or viral vectors.
Knowledge in PCR gene amplification and qRT-PCR gene expression, gene sequencing assay.
Bioenergetics: Evaluation of mitochondrial function (ex.
oxygen consumption, membrane potential and ROS production) in
vivo or pos-fixation either by microscopy or flow cytometer.
Toxicology: Toxicological mechanisms of anti-tumor compounds in mitochondrial dysfunction (cell lines).
Cardiovascular: Use of Langendorf heart and TTC staining to access hemodynamic alterations and infarct size during ischemia-reperfusion
Experimental Biology: Handling and experimentation of laboratory animals (rats)
Current research interests
Heat shock proteins: HSPs role in cancer development, namely TRAP1 a HSP90 family member.
Role of TRAP1 in the development
of a chemoresistant phenotype by tumor cells.
Cell death pathways: Apoptosis programed cell death pathways in tumor versus normal cells.
Autophagy pathways in normal
and tumor cells.
Autophagy and tumor cell progression and death promotion.
Cancer metabolism: Role of mitochondria and its morphological and metabolic changes during tumor development.
Autophagy: Autophagy and its role in mitochondrial quality control and cell death.
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