Carla Lopes Varela
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Data da última atualização
»Last update
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25/09/2014 |
Dados pessoais (Personal data)
Nome completo
Full name |
Carla Lopes Varela |
Nome em citações bibliográficas
Quoting name |
Varela, Carla L. |
Categoria profissional
Position |
Investigador Auxiliar |
Domínio científico de atuação
Scientific domain |
Ciências Médicas-Ciências da Saúde.
Ciências Exactas-Química.
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Endereço profissional
Professional address |
Universidade de Coimbra
Faculdade de Farmácia
Pólo das Ciências da Saúde Azinhaga de Santa Comba
Coimbra
3000--548 Coimbra
Portugal
Telefone: (+351)239488400Extensão: 17635
Correio electrónico: carla.varela@portugalmail.com |
Sexo
Gender |
Feminino»Female |
Graus Académicos
(Academic Degrees)
| 2009-2013 |
Doutoramento
Phd |
Doutoramento em Farmácia, especialidade de Química Farmacêutica
(4 anos » years)
.
Universidade de Coimbra,
Portugal.
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| 2002-2008 |
Licenciatura
Licentiate degree |
Mestrado Integrado em Ciências Farmacêuticas
(6 anos » years)
.
Universidade de Coimbra,
Portugal.
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Vínculos profissionais
(Professional Positions)
| Jul/2013-Actual |
Investigador Auxiliar |
| Abr/2009-Mar/2013 |
Outra Situação |
| Farmácia Castanheira de Febres, Cantanhede |
| Mar/2008-Mar/2009 |
Outra Situação |
Atividades de Investigação e Desenvolvimento (Research and Development activities)
Estágios realizados (Traineeships)
Estágios realizados»Traineeships:
- Scientific research internship at the Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, University of Coimbra
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Estágios realizados»Traineeships:
- Scientific research project at the Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, University of Coimbra,
within the subject of Chemical and Enzymatic Synthesis
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Estágios realizados»Traineeships:
- Internship at the Pharmacy Romahnja in Belgrade, Serbia, under the SEP program (Students Exchange Program)
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Estágios realizados»Traineeships:
- Internship at the Pharmacy Galeno, Vila Real
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Estágios realizados»Traineeships:
- Internship at the Pharmacy of the Hospital Centre of Trás-os-Montes e Alto Douro, Vila Real
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Linhas de Investigação (Research fields)
| 1. |
Design, synthesis and structure-activity relationships studies on steroidal aromatase and 5alpha-reductase inhibitors as anti-tumors |
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| 2. |
Design and synthesis of coumarins as potential aromatase inhibitors |
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Projetos de Investigação (Research projects)
Outro Tipo de Participação
Other kind of participation |
2012-
New Enzymatic Inhibitors Against Breast and Prostate Cancer: A Contribution To Ameliorate the Bone Loss and Endocrine Resistance |
| Referência do projeto»Project reference: PTDC/QUI-BIQ/120319/2010.
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Línguas (Languages)
Compreende
Understandig |
Inglês (Bem), Espanhol (Razoavelmente), Francês (Razoavelmente). |
Fala
Speaking |
Inglês (Bem), Espanhol (Razoavelmente). |
Lê
Reading |
Inglês (Bem), Espanhol (Razoavelmente), Francês (Razoavelmente). |
Escreve
Writing |
Inglês (Bem). |
Prémios e títulos (Awards Prizes, and Honours)
| 2013 |
ESMEC fellowship to attend the 33rd edition of the European School of Medicinal Chemistry, Urbino, Italy, 7-12 July 2013,
Scientific Committee of the European School of Medicinal Chemistry (ESMEC- Urbino) and the European .
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| 2012 |
Best Oral Communication in the “Drug Discovery” area, presented at the Conference CEF 2012,
Hovione, Center for Pharmaceutical Studies and Faculty of Pharmacy .
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| 2005 |
Award given as the first author for the best oral communication entitled “Separation and collection of urban solid waste:
habits and attitudes”,
Portuguese Pharmacists Association .
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| 2009 |
Scholarship SFRH/BD/44872/2008,
Fundação para a Ciência e a Tecnologia Ministério da Educação e Ciência .
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| 2012 |
Bentham scholarship under the “XXII International Symposium on Medicinal Chemistry”, Berlin, Germany, 2-6 of September of
2012,
Bentham and European Federation of Medicinal Chemistry.
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| 2010 |
Award for the 3% best students of each course, for the academic year of 2006/2007,
University of Coimbra.
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| 2010 |
Bentham scholarship under the “XXI International Symposium on Medicinal Chemistry”, Brussels, Belgium, 5-9 of September of
2010,
Bentham .
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| 2010 |
Scholarship from the European Federation on Medicinal Chemistry under the “XXI International Symposium on Medicinal Chemistry”,
Brussels, Belgium, 5-9 of September of 2010,
European Federation on Medicinal Chemistry.
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| 2008 |
Award “Sociedade Farmacêutica Lusitana” that distinguishes the young pharmacists who have concluded their academic degree
in Portugal with the highest classification,
Portuguese Pharmacists Association.
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| 2008 |
Award for the 3% best students of each course, for the academic year of 2005/2006,
University of Coimbra.
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| 2007 |
Award for the 3% best students of each course, for the academic year of 2004/2005,
University of Coimbra.
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| 2005 |
Award Paracelsus given to the student with best grade of the subject Organic Chemistry,
Rectory of the University of Coimbra.
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Membro de Associações Profissionais/Científicas (Professional/Scientific Association membership)
| Ago/2008 - Actual |
Ordem dos Farmacêuticos, Membro.
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Produção científica, técnica e artística/cultural
(Scientific, technical and artistical/cultural
production)
Artigos em revistas com arbitragem científica
Papers in periodics with scientific refereeing |
| 1. |
Roleira, F. M. F; Tome , C; Bernardo, T.; Serafim, T.; Oliveira, Paulo J; Varela, Carla; Borges, Fernanda; Carvalho, R. A. 2011. "DESIGN, SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITIES OF CINNAMIC AND HYDROCINNAMIC ACID LIPOPHILIC DERIVATIVES", European Journal of Pharmaceutical Sciences 44, 1-2: 176 - 176.
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Trabalhos completos/resumidos em eventos com arbitragem científica
Papers in conference proceedings with scientific refereeing |
| 1. |
Varela, C.; Carvalho, R.; Oliveira, P.; Serafim, T.; Roleira, F.; Tavares-da-Silva, E.; Bernardo, T.; Borges, F.; Tome, C.. 2011. "DESIGN, SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITIES OF CINNAMIC AND HYDROCINNAMIC ACID LIPOPHILIC DERIVATIVES", Trabalho apresentado em 4th BBBB-Bled International Conference on Pharmaceutical Sciences - New Trends in Drug Discovery, Delivery Systems and Laboratory
Diagnostics, In EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Bled, SLOVENIA. |
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Artigos em revistas sem arbitragem científica
Papers in periodics without scientific refereeing |
| 1. |
Varela, Carla L; Roleira, Fernanda M. F; Costa, Saul C; Pinto, Alexandra S. C. T; Martins, Ana I. O. S; Carvalho, Rui A; Teixeira, Natércia; Correia-da-Silva, Georgina; Tavares-da-Silva, Elisiário J. 2014. "Insights Into the Synthesis of Steroidal A-ring Olefins", Helvetica Chimica Acta 97, 1: 39 - 46. |
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| 2. |
Varela, Carla L; Amaral, Cristina; Correia-da-Silva, Georgina; Carvalho, Rui A; Teixeira, Natércia A; Costa, Saul C; Roleira, Fernanda M; Tavares-da-Silva, Elisiário J. 2013. "Design, synthesis and biochemical studies of new 7a-allylandrostanes as aromatase inhibitors", Steroids 78, 7: 662 - 669.
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| 3. |
 Amaral, Cristina; Varela, Carla L; Azevedo, Margarida; da Silva, E. T; Roleira, Fernanda M; Chen, Shiuan; Correia-da-Silva, Georgina; Teixeira, Natércia. 2013. "Effects of Steroidal Aromatase Inhibitors on Sensitive and Resistant Breast Cancer Cells: Aromatase Inhibition and Autophagy", The Journal of Steroid Biochemistry and Molecular Biology 135, -: 51 - 59.
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| 4. |
Amaral, Cristina; Varela, Carla L; Correia-da-Silva, Georgina; Tavares-da-Silva, Elisiário J; Carvalho, Rui A; Costa, Saul C; Cunha, Sara C; Fernandes, José O; Teixeira, Natércia; Roleira, Fernanda M. 2013. "New Steroidal 17ß-Carboxy Derivatives Present Anti-5a-Reductase Activity and Anti-proliferative Effects in a Human Androgen-Responsive
Prostate Cancer Cell Line", Biochimie, 2013: 1 - 10. |
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| 5. |
Amaral, Cristina; Varela, Carla; Borges, Margarida; Tavares da S. E; Roleira, Fernanda M. F; Correia-da-Silva, Georgina; Teixeira, Natércia. 2013. "Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis", Apoptosis, -: 1 - 11.
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| 6. |
Varela, Carla L; Tavares da S. E. J; Amaral, Cristina; Correia da S. G; Baptista, Teresa; Alcaro, Stefano; Costa, Giosuè; Carvalho, Rui A; Teixeira, Natércia A. A; Roleira, Fernanda M. F. 2012. "New Structure–Activity Relationships of A- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis, and Biochemical
Evaluation", Journal of Medicinal Chemistry 55, 8: 3992 - 4002.
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| 7. |
Andrade, L. C. R; Almeida, M. J. M.; Fernandes Roleira, F. M; Varela, Carla L; Tavares da S. E. J. 2012. "6-Methylideneandrost-4-ene-3,17-dione", Acta Crystallographica Section E Structure Reports Online 68, 4: o1263 - o1263.
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| 8. |
Varela, Carla L; Andrade, L. C. R; Almeida, M. J. M.; Roleira, Fernanda M; Tavares-da-Silva, Elisiário J. 2008. "(E)-17-Oximino-5-alpha-androst-3-ene", Acta Crystallogr., C64,: o508 - o508. |
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Trabalhos completos/resumidos em eventos sem arbitragem científica
Papers in conference proceedings without scientific refereeing |
| 1. |
Varela, Carla L; Tavares-da-Silva, Elisiário J; Lopes, A.; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Carvalho, Rui A; Ribeiro, P.; Teixeira, Natércia; Roleira, Fernanda M. 2014. "Exemestane Metabolites: Synthesis, Stereochemical Elucidation and Mechanism of Action in Breast Cancer", Trabalho apresentado em 22nd Conference on Isoprenoids, In CHEMICKE LISTY, Praga. |
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| 2. |
Varela, Carla L; Roleira, Fernanda M. F; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2014. "Exploring New Chemical Functionalities to Improve Aromatase Inhibition of Steroids ", Trabalho apresentado em 22nd Conference on Isoprenoids, In CHEMICKE LISTY, Praga. |
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| 3. |
Varela, Carla L; Roleira, Fernanda M; Costa, Saul C; Carvalho, Rui A; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2014. "Targeting Aromatase in Breast Cancer: New Steroidal Olefins and Epoxides as Aromatase Inhibitors and Structure-Activity Relationships", Trabalho apresentado em 22nd Conference on Isoprenoids, In CHEMICKE LISTY, Praga. |
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| 4. |
Varela, Carla L; Roleira, Fernanda M. F; Costa, Saul C; Carvalho, Rui A; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2013. "Steroidal Aromatase Inhibitors in Breast Cancer Research. Structure and Substrate-Guided Design, Synthesis and Structure-Activity
Relationships (SAR)", Trabalho apresentado em 5th International BBBB Conference, In European Journal of Pharmaceutical Sciences, Atenas. |
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| 5. |
Varela, Carla L; Tavares-da-Silva, Elisiário J; Amaral, Cristina; Correia-da-Silva, Georgina; Carvalho, Rui A; Costa, Saul C; Cunha, S.; Fernandes, J.; Teixeira, Natércia; Roleira, Fernanda M. F. 2013. "Design, Synthesis and Evaluation of New Steroidal 17 -Carboxy Derivatives as 5a-Reductase Inhibitors", Trabalho apresentado em 5th International BBBB Conference, In European Journal of Pharmaceutical Sciences, Atenas. |
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| 6. |
Varela, Carla L; Roleira, Fernanda M. F; Lopes, A.; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2013. "Exemestane Potential Metabolites – Design, Synthesis and Studies in Breast Cancer Cells", Trabalho apresentado em 5th International BBBB Conference, In European Journal of Pharmaceutical Sciences, Atenas. |
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| 7. |
Roleira, Fernanda M; Tavares-da-Silva, Elisiário J; Varela, Carla L; Bernardo, T.; Serafim, T.; Oliveira, P.; Teixeira, J.; Garrido, J.; Borges, F.. 2012. "New Lipophilic Cinnamic Acid Derivatives. Correlation between Antioxidant and Antiproliferative Activities towards Breast
Cancer Cell Lines", Trabalho apresentado em XXII International Symposium on Medicinal Chemistry , In ChemMedChem, Berlin. |
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| 8. |
Varela, Carla L; Tavares-da-Silva, Elisiário J; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Pinto, Alexandra S. C. T; Simões, Ana; Carvalho, Rui A; Teixeira, Natércia; Roleira, Fernanda M. F. 2012. "A-, B- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis and Biochemical Studies", Trabalho apresentado em XXII International Symposium on Medicinal Chemistry, In ChemMedChem, Berlin. |
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| 9. |
Roleira, Fernanda M. F; Tomé, C.; Bernardo, T.; Serafim, T.; Oliveira, P.; Varela, Carla L; Borges, F.; Carvalho, Rui A; Tavares-da-Silva, Elisiário J. 2011. "Design, Synthesis and Antiproliferative Activities of Cinnamic and Hydrocinnamic Acid Lipopilic Derivatives", Trabalho apresentado em 4th BBBB – Bled International Conference on Pharmaceutical Sciences, In European Journal of Pharmaceutical Sciences, Bled. |
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| 10. |
Varela, Carla L; Roleira, Fernanda M. F; Cepa, Margarida; Azevedo, Margarida; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2010. "Design Synthesis and Biological Evaluation Towards Aromatase of C-4 Derivatives of Formestane and 5alpha-Androst-3-en-17-one", Trabalho apresentado em XXI International Symposium on Medicinal Chemistry, In Drug Future, Brussels. |
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| 11. |
Varela, Carla L; Tavares-da-Silva, Elisiário J; Cepa, Margarida; Azevedo, Margarida; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Roleira, Fernanda M. 2010. "Structure-Activity Relationships on D-Ring Modified 3-Deoxy-3-Androstenes as Aromatase inhibitors", Trabalho apresentado em XI International Symposium on Medicinal Chemistry, In Drug Future, Brussels. |
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| 12. |
Varela, Carla L; Roleira, Fernanda M; Correia-da-Silva, Georgina; Cepa, Margarida; Dias, Ana; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2009. "Androstenes vs Epoxyandrostanes. The role of the Planarity of the A-Ring in Aromatase Inhibition. A Structure-Activity Study", Trabalho apresentado em Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies, In Drug Future, Barcelona. |
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| 13. |
Roleira, Fernanda M. F; Sintra, Tânia; Varela, Carla L; Correia-da-Silva, Georgina; Cepa, Margarida; Dias, Ana; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. 2009. "The Effect of C-3 Stereochemistry in the Aromatase Inhibitory Activity of 3-Hydroxy-4-Androstenes. A Structure-Activity Study", Trabalho apresentado em Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies, In Drug Future, Barcelona. |
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| 14. |
Tavares-da-Silva, Elisiário J; Cepa, Margarida; Correia-da-Silva, Georgina; Teixeira, Natércia; Varela, Carla L; Roleira, Fernanda M. 2008. "Structure-Activity Relationships on 4-Androstenes and 5alpha-Androstan-4-ones as Aromatase Inhibitors", Trabalho apresentado em XX International Symposium on Medicinal Chemistry , In Drug Future, Vienna. |
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Apresentação oral de trabalho
Oral work presentation |
| 1. |
Varela, Carla L; Tavares-da-Silva, Elisiário J; Lopes, A.; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Carvalho, Rui A; Ribeiro, P.; Teixeira, Natércia; Roleira, Fernanda M. F. Exemestane Metabolites: Synthesis, Stereochemical Elucidation and Mechanism of Action in Breast Cancer,22nd Conference on Isoprenoids,Prague,2014 (Congresso). |
| 2. |
Maurício, J.; Amaral, Cristina; Varela, Carla L; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M. F; Costa, Saul C; Correia-da-Silva, Georgina; Teixeira, Natércia. New 7a-allylandrostanes as Aromatase Inhibitors: Biological Effects in Hormone-dependent and Hormone-resistant Breast Cancer
Cells,7th Meeting of Young Researchers at UP,Porto,2014 (Conferência ou palestra). |
| 3. |
Amaral, Cristina; Lopes, A.; Varela, Carla L; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M; Correia-da-Silva, Georgina; Teixeira, Natércia. Effects of Exemestane Metabolites in Sensitive and Resistant Breast Cancer Cells: Role of Autophagy,Annual Meeting of the Portuguese Pharmacology Society,Coimbra,2014 (Congresso). |
| 4. |
Varela, Carla L; Roleira, Fernanda M. F; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. Exploring New Chemical Functionalities to Improve Aromatase Inhibition of Steroids ,22nd Conference on Isoprenoids,Prague,2014 (Congresso). |
| 5. |
Lemos, A.; Amaral, Cristina; Lopes, A.; Varela, Carla L; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M. F; Costa, Saul C; Teixeira, Natércia; Correia-da-Silva, Georgina. Biological Evaluation of New Steroidal Compounds: Aromatase Inhibition and Effects in MCF-7aro Cells Viability,7th Meeting of Young Researchers at UP,Porto,2014 (Poster). |
| 6. |
Varela, Carla L; Roleira, Fernanda M. F; Costa, Saul C; Carvalho, Rui A; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. Targeting Aromatase in Breast Cancer: New Steroidal Olefins and Epoxides as Aromatase Inhibitors and Structure-Activity Relationships,22nd Conference on Isoprenoids ,Prague,2014 (Congresso). |
| 7. |
Varela, Carla L; Roleira, Fernanda M; Costa, Saul C; Carvalho, Rui A; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia A; Tavares-da-Silva, Elisiário J. STEROIDAL AROMATASE INHIBITORS IN BREAST CANCER RESEARCH. STRUCTURE AND SUBSTRATE-GUIDED DESIGN, SYNTHESIS AND STRUCTURE-ACTIVITY
RELATIONSHIPS (SAR) ,5th BBBB International Conference,2013 (Conferência ou palestra). |
| 8. |
Varela, Carla L; Tavares-da-Silva, Elisiário J; Amaral, Cristina; Correia-da-Silva, Georgina; Carvalho, Rui A; Costa, Saul C; Cunha, S.; Fernandes, J.; Teixeira, Natércia A; Roleira, Fernanda M. F. NEW STEROIDAL 17ß-CARBOXY DERIVATIVES – DESIGN, SYNTHESIS AND EVALUATION AS 5a-REDUCTASE INHIBITORS,IV CEF Conference 2013,2013 (Comunicação). |
| 9. |
Varela, Carla L. Design, Synthesis and Structure-activity Relationships Studies on Steroidal Aromatase and 5a-Reductase Inhibitors as Anti-tumors,European School of Medicinal Chemistry – XXXIII Advanced Course of Medicinal Chemistry and “E. Duranti” National Seminar for
PhD Students,Urbino,2013 (Poster). |
| 10. |
Varela, Carla L; Roleira, Fernanda M; Lopes, A.; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia A; Tavares-da-Silva, Elisiário J. EXEMESTANE POTENTIAL METABOLITES – DESIGN, SYNTHESIS AND STUDIES IN BREAST CANCER CELLS,5th BBBB International Conference,2013 (Poster). |
| 11. |
Varela, Carla L; Roleira, Fernanda M; Lopes, A.; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia A; Tavares-da-Silva, Elisiário J. DESIGN, SYNTHESIS AND STUDY OF POTENTIAL METABOLITES OF EXEMESTANE IN BREAST CANCER CELLS,IV CEF Conference,2013 (Poster). |
| 12. |
Lopes, A.; Amaral, Cristina; Varela, Carla L; Roleira, Fernanda M. F; Tavares-da-Silva, Elisiário J; Correia-da-Silva, Georgina; Teixeira, Natércia. Exemestane Metabolites: Effects on Breast Cancer Cell Proliferation and Induction of Cell Death,6th Meeting of Young Researchers at UP,Porto,2013 (Conferência ou palestra). |
| 13. |
Varela, Carla L; Tavares-da-Silva, Elisiário J; Amaral, Cristina; Correia-da-Silva, Georgina; Carvalho, Rui A; Costa, Saul C; Cunha, S.; Fernandes, J.; Teixeira, Natércia; Roleira, Fernanda M. DESIGN, SYNTHESIS AND EVALUATION OF NEW STEROIDAL 17ß-CARBOXY DERIVATIVES AS 5a-REDUCTASE INHIBITORS,5yh BBBB International Conference,2013 (Poster). |
| 14. |
Amaral, Cristina; Varela, Carla L; Borges, M.; Roleira, Fernanda M. F; Tavares-da-Silva, Elisiário J; Correia-da-Silva, Georgina; Teixeira, Natércia. The Aromatase Inhibitors Androst-4-en-17-one and 4a,5a-Epoxyandrostan-17-one: Biological Effects in an Estrogen Receptor-Positive
Aromatase-Overexpressing Breast Cancer Cell Line (MCF-7aro),Cell Death in Cancer Conference – EACR,Amsterdam,2012 (Poster). |
| 15. |
Varela, Carla L; Tavares-da-Silva, Elisiário J; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Pinto, Alexandra S. C. T; Simões, Ana; Carvalho, Rui A; Teixeira, Natércia; Roleira, Fernanda M. A-, B- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis and Biochemical Studies,XXII International Symposium on Medicinal Chemistry,Berlin,2012 (Poster). |
| 16. |
Varela, Carla L; Tavares-da-Silva, Elisiário J; Amaral, Cristina; Correia-da-Silva, Georgina; Costa, Saul C; Pinto, Alexandra S. C. T; Simões, Ana; Carvalho, Rui A; Teixeira, Natércia; Roleira, Fernanda M. F. Structure-Activity Relationships of A-, B- and D-Ring Modified Steroidal Aromatase Inhibitors,Conference CEF 2012,Coimbra,2012 (Conferência ou palestra). |
| 17. |
Amaral, Cristina; Varela, Carla L; Azevedo, Margarida; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M; Chen, S.; Correia-da-Silva, Georgina; Teixeira, Natércia. Effects of New Steroidal Aromatase Inhibitors on Sensitive and Resistant Breast Cancer Cells,One Day Symposium on Darwinian evolution and clonal heterogeneity in human cancer: biological and clinical implications,Porto,2012 (Poster). |
| 18. |
Roleira, Fernanda M. F; Tavares-da-Silva, Elisiário J; Varela, Carla L; Bernardo, T.; Serafim, T.; Oliveira, P.; Teixeira, J.; Garrido, J.; Borges, F.. Cinnamic Acid Derivatives. Design, Synthesis, Antioxidant Profile and Antiproliferative Activities Towards Breast Cancer Cell
Lines,Conference CEF 2012,Coimbra,2012 (Poster). |
| 19. |
Lopes, A.; Amaral, Cristina; Varela, Carla L; Roleira, Fernanda M; Tavares-da-Silva, Elisiário J; Correia-da-Silva, Georgina; Teixeira, Natércia. Comparative Study of Exemestane Metabolites in a Breast Cancer Cell Model,XXI Porto Cancer Meeting – Metabolism and Cancer, from etiopathogenesis to therapy,Porto,2012 (Poster). |
| 20. |
Roleira, Fernanda M. F; Tavares-da-Silva, Elisiário J; Varela, Carla L; Bernardo, T.; Serafim, T.; Oliveira, P.; Teixeira, J.; Garrido, J.; Borges, F.. New Lipophilic Cinnamic Acid Derivatives. Correlation between Antioxidant and Antiproliferative Activities towards Breast
Cancer Cell Lines,XXII International Symposium on Medicinal Chemistry,Berlin,2012 (Poster). |
| 21. |
Amaral, Cristina; Azevedo, Margarida; Borges, M.; Varela, Carla L; Roleira, Fernanda M; Tavares-da-Silva, Elisiário J; Correia-da-Silva, Georgina; Teixeira, Natércia. Effects of Two Aromatase Inhibitors in Cell Proliferation and Cell Death in an Estrogen-dependent Breast Cancer Cell Line
(MCF-7aro),Second I3S Scientific Retreat,Porto,2011 (Poster). |
| 22. |
Roleira, Fernanda M; Tomé, C.; Bernardo, T.; Serafim, T.; Oliveira, P.; Varela, Carla L; Borges, F.; Carvalho, Rui A; Tavares-da-Silva, Elisiário J. Desing, Synthesis and Antiproliferativo Activities of Cinnamic and Hydrocinnamic Acid Lipopilic Derivatives,4th BBBB – Bled International Conference on Pharmaceutical Sciences,Bled,2011 (Poster). |
| 23. |
Amaral, Cristina; Azevedo, Margarida; Borges, M.; Varela, Carla L; Cepa, Margarida; Roleira, Fernanda M. F; Tavares-da-Silva, Elisiário J; Correia-da-Silva, Georgina; Teixeira, Natércia. Effects of Two Steroidal Aromatase Inhibitors in an Estrogen Receptor-Positive Aromatase-Overexpressing Breast Cancer Cell
Line (Mcf-7aro),XX Porto Cancer Meeting,Porto,2011 (Poster). |
| 24. |
Varela, Carla L. Seeking for a New Framework in Steroids Aiming Aromatase Inhibition,2nd ScienCEF,Coimbra,2011 (Conferência ou palestra). |
| 25. |
Varela, Carla L; Tavares-da-Silva, Elisiário J; Costa, Saul C; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Roleira, Fernanda M. F. Design, Synthesis and Biochemical Screening Towards Aromatase of C-17 Derivatives of 7a-Allylandrostenedione As Well As Its
1-Ene and 3-Deoxo Analogs,Frontiers in Medicinal Chemistry Meeting,Stockholm,2011 (Poster). |
| 26. |
Amaral, Cristina; Azevedo, Margarida; Varela, Carla L; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M. F; Correia-da-Silva, Georgina; Teixeira, Natércia. Effects of A- and D-Ring Modified Steroids in Aromatase Activity,2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery,Porto,2011 (Poster). |
| 27. |
Varela, Carla L; Roleira, Fernanda M. F; Costa, Saul C; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. New Structure-Activity Relationships (SAR) of 7a-Allyl Derivatives of Androstenedione as Aromatase Inhibitors Towards Breast
Cancer Research,Conference CEF 2011,Coimbra,2011 (Poster). |
| 28. |
Roleira, Fernanda M; Tomé, C.; Bernardo, T.; Serafim, T.; Oliveira, P.; Varela, Carla L; Borges, F.; Tavares-da-Silva, Elisiário J. Lipophilic Derivatives of Cinnamic and Hydrocinnamic Acids. Design, Synthesis and Antiproliferative Activities,Conference CEF 2011,Coimbra,2011 (Poster). |
| 29. |
Varela, Carla L; Roleira, Fernanda M. F; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. Structure-Activity Relationships of A-, B- and D-Ring Modified Steroidal Aromatase Inhibitors,2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery,Porto,2011 (Congresso). |
| 30. |
Varela, Carla L; Roleira, Fernanda M; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. New A-Ring Steroidal Olefins and Epoxides as Aromatase Inhibitors. Design, Synthesis, Biochemical Evaluation and SAR,Frontiers in Medicinal Chemistry Meeting,Stockholm,2011 (Poster). |
| 31. |
Dias, Ana; Correia-da-Silva, Georgina; Amaral, Cristina; Borges, M.; Cepa, Margarida; Varela, Carla L; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M. F; Teixeira, Natércia. Two New Aromatase Inhibitors: Biological Evaluation and Effects in an Estrogen-Dependent Breast Cancer Cell Line,3rd Meeting of Young Researchers of U. Porto,Porto,2010 (Conferência ou palestra). |
| 32. |
Varela, Carla L; Tavares-da-Silva, Elisiário J; Cepa, Margarida; Azevedo, Margarida; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Roleira, Fernanda M. F. Structure-Activity Relationships on D-Ring Modified 3-Deoxy-3-Androstenes as Aromatase inhibitors,XXI International Symposium on Medicinal Chemistry,Brussels,2010 (Poster). |
| 33. |
Varela, Carla L; Roleira, Fernanda M; Amaral, Cristina; Correia-da-Silva, Georgina; Azevedo, Margarida; Cepa, Margarida; Teixeira, Natércia; Alcaro, S.; Costa, G.; Tavares-da-Silva, Elisiário J. Steroidal Aromatase Inhibitors in Breast Cancer Research. New Structure-Activity Relationships (SAR) and Docking Studies on
Androstenedione Based Inhibitors,Conference CEF 2010,Coimbra,2010 (Poster). |
| 34. |
Amaral, Cristina; Azevedo, Margarida; Varela, Carla L; Cepa, Margarida; Tavares-da-Silva, Elisiário J; Roleira, Fernanda M; Correia-da-Silva, Georgina; Teixeira, Natércia. New A-D-ring Modified Steroids as Aromatase Inhibitors: Structure-Activity Relationship Studies,I3S Scientific Retreat,Porto,2010 (Poster). |
| 35. |
Amaral, Cristina; Azevedo, Margarida; Borges, M.; Varela, Carla L; Cepa, Margarida; Roleira, Fernanda M. F; Tavares-da-Silva, Elisiário J; Correia-da-Silva, Georgina; Teixeira, Natércia. Effects of Two Aromatase Inhibitors in Cell Proliferation and Cell Death in an Estrogen-dependent Breast Cancer Cell Line,Eighth International Conference on Mechanisms of Cell Death and Disease. Advances in Therapeutic Intervention and Drug Development,Cascais,2010 (Poster). |
| 36. |
Varela, Carla L. Looking for Chemical Key-features in the A-ring of Steroids Aiming Inhibition of Aromatase,1st ScienCEF,Coimbra,2010 (Conferência ou palestra). |
| 37. |
Amaral, Cristina; Azevedo, Margarida; Mota, V.; Varela, Carla L; Cepa, Margarida; Roleira, Fernanda M; Correia-da-Silva, Georgina; Teixeira, Natércia. A- and D-Rings Modified Steroids as Potential Aromatase Inhibitors: Aromatase Activity Evaluation and Kinetic Studies,XVII National Biochemistry Congress,Porto,2010 (Poster). |
| 38. |
Varela, Carla L; Roleira, Fernanda M; Cepa, Margarida; Azevedo, Margarida; Amaral, Cristina; Correia-da-Silva, Georgina; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. Design, Synthesis and Biological Evaluation Towards Aromatase of C-4 Derivatives of Formestane and 5alpha-Androst-3-en-17-one,XXI International Symposium on Medicinal Chemistry,Brussels,2010 (Poster). |
| 39. |
Varela, Carla L; Roleira, Fernanda M. F; Correia-da-Silva, Georgina; Cepa, Margarida; Dias, Ana; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. Androstenes vs Epoxyandrostanes. The role of the Planarity of the A-Ring in Aromatase Inhibition. A Structure-Activity Study,Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies,Barcelona,2009 (Poster). |
| 40. |
Roleira, Fernanda M. F; Sintra, T.; Varela, Carla L; Correia-da-Silva, Georgina; Cepa, Margarida; Dias, Ana; Teixeira, Natércia; Tavares-da-Silva, Elisiário J. The Effect of C-3 Stereochemistry in the Aromatase Inhibitory Activity of 3- Hydroxy-4-Androstenes. A Structure-Activity Study,Frontiers in Medicinal Chemistry: Emerging T argets, Novel Candidates and Innovative Strategies,Barcelona,2009 (Poster). |
| 41. |
Tavares-da-Silva, Elisiário J; Cepa, Margarida; Correia-da-Silva, Georgina; Teixeira, Natércia; Varela, Carla L; Roleira, Fernanda M. Structure-Activity Relationships on 4-Androstenes and 5alpha-Androstan-4-ones as Aromatase Inhibitors,XX International Symposium on Medicinal Chemistry,Vienna,2008 (Poster). |
| 42. |
Tavares-da-Silva, Elisiário J; Cepa, Margarida; Correia-da-Silva, Georgina; Teixeira, Natércia; Varela, Carla L; Roleira, Fernanda M. F. Structure-Based Design, Synthesis, and Biological Evaluation of New Steroids Aromatase Inhibitors,Symposium on Advances on Synthetic and Medicinal Chemistry,Saint Petersburg,2007 (Poster). |
| 43. |
Varela, Carla L. EQOFAR,Environmental Health Seminar,2006 (Poster). |
| 44. |
Cruz, Filipa; Matos, Cyntia; Varela, Carla L; Moreno, Mª J. S. M. ECODYNAMIC – Environmental Education for Adults,Environmental Health Seminar,2006 (Poster). |
| 45. |
Varela, Carla L; Caçador, Catarina; Moreno, Mª J. S. M. Separation and collection of urban solid waste: habits and attitudes,I Educational Forum of Organic Chemistry in Pharmaceutical Sciences,2005 (Simpósio). |
| 46. |
Cruz, Filipa; Matos, Cyntia; Varela, Carla L; Moreno, Mª J. S. M. Ecodynamic Program – Environmental Education for Adults,I Educational Forum of Organic Chemistry in Pharmaceutical Sciences,2005 (Simpósio). |
Curso de curta duração lecionado
Taught short course |
| 1. |
Varela, Carla L. Synthesis of Aspirin, 2014 (Extensão), promovido por Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, University of Coimbra; 28 March 2014 (Escola 2,3/S Dr. Manuel
Ribeiro Ferreira – Agrupamento de Escolas de Alavaiázere). |
| 2. |
Varela, Carla L. Synthesis of aspirin, 2014 (Extensão), promovido por Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, University of Coimbra; 5 June 2014 (Escola Básica Grão Vasco
do Agrupamento de Escolas Zona Urbana de Viseu). |
| 3. |
Varela, Carla L. “Como preparar o Paracetamol?” - Universidade de Verão, Faculdade de Farmácia, Universidade de Coimbra, 2014 (Extensão). |
| 4. |
Varela, Carla L. Synthesis of Aspirin - Summer University, at the Faculty of Pharmacy, University of Coimbra, 2013 (Extensão), promovido por Faculty of Pharmacy, University of Coimbra.Tipo de participação: Outra. |
| 5. |
Varela, Carla L. Synthesis of Aspirin, 2013 (Extensão), promovido por Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, University of Coimbra; 3 April 2013 (Escola Secundária de
Ourém). |
| 6. |
Varela, Carla L. Synthesis of Aspirin, 2013 (Extensão), promovido por Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, University of Coimbra; 14 March 2013 (Escola José Falcão,
Coimbra). |
| 7. |
Varela, Carla L. Synthesis of Aspirin - Summer University, at the Faculty of Pharmacy, University of Coimbra, 2010 (Extensão), promovido por Faculty of Pharmacy, University of Coimbra. |
| 8. |
Varela, Carla L. Public Health and Environment – 3E’s Program, 2006 (Extensão), promovido por Portuguese Pharmacists Association, regional section of Coimbra; 6 March 2006.Tipo de participação: Outra. |
| 9. |
Varela, Carla L. Public Health and Environment – 3E’s Program, 2006 (Extensão), promovido por Portuguese Pharmacists Association, regional section of Coimbra; 12 January 2006. |
| 10. |
Varela, Carla L. Public Health and Environment – 3E’s Program, 2006 (Extensão), promovido por Portuguese Pharmacists Association, regional section of Porto; 19 May 2006.Tipo de participação: Outra. |
Organização de evento
Event organization |
| 1. |
Varela, Carla L. 2nd Iberic Meeting on Medicinal Chemistry - G Protein-Coupled Receptors an Enzymes in Drug Discovery,2011 (Encontro). |
| 2. |
Varela, Carla L. 1st Iberic Meeting on Medicinal Chemistry – Anticancer Agents,2007 (Encontro). |
| 3. |
Varela, Carla L. I Educational Forum of Organic Chemistry in Pharmaceutical Sciences,2005 (Encontro). |
| 4. |
Varela, Carla L. EQOFAR – Estudantes de Química Orgânica – Acção/Reacção (Students of organic chemistry – action/reaction), of the Faculty
of Pharmacy, University of Coimbra,2004 (Outro). |
Dados Complementares (Additional data)
Trabalho de conclusão de curso de Bacharelato/Licenciatura
Bachelor/Licenciate degree conclusion work |
| 1. |
Enza Lo Giudice, Design, synthesis and biochemical studies of 7a-vinyl derivatives of androstenedione as aromatase inhibitors, 2013. (Co-orientador). |
| 2. |
Valeria Muliello , Design, synthesis and biochemical studies of derivatives of 4-androstene-17ß-carboxylic acid as 5a-reductase inhibitors, 2013. (Co-orientador). |
| 3. |
Valentina Valastro , Synthesis of the analogue 3,4-cyclopropan from the aromatase inhibitor 5a-androst-3-ene-17-one, 2011. (Co-orientador). |
| 4. |
Michael Jefferson Amorim de Oliveira , Design, synthesis and evaluation of amebicide activity of nitazoxanide analogs, 2011. (Co-orientador). |
Iniciação científica
Scientific initiation |
| 1. |
Iti-Ingris Sei, Synthesis and purification of two amides: hexylamide of 3,4,5-trihydroxycinnamic acid and of hydrocaffeic acid., 2014. (Co-orientador). |
| 2. |
Annela Toom , Synthesis and purification of two amides: hexylamide of 3,4,5-trihydroxycinnamic acid and of hydrocaffeic acid., 2014. (Co-orientador). |
| 3. |
Mónica Morera , Follow up and participation within the ongoing PhD activities “Design, synthesis and structure-activity studies of steroidal
inhibitors of aromatase and 5a-reductase as anti-tumors”, 2012. (Co-orientador). |
| 4. |
Alina Grecu, Follow up and participation within the ongoing PhD activities “Design, synthesis and structure-activity studies of steroidal
inhibitors of aromatase and 5a-reductase as anti-tumors”, 2012. (Co-orientador). |
| 5. |
Alexandra Tolda Pinto, Design, synthesis and biochemical studies of 4,5-epoxy- and 4,5-cyclopropan-3-desoxyandrostan-17-one derivatives as aromatase
inhibitors, 2011. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador). |
| 6. |
Ana Isabel Martins , Design, synthesis and biochemical studies of 3-desoxy analogues of ¿6-androstenedione and its 7a-allyl derivatives as aromatase
inhibitors, 2011. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador). |
| 7. |
Luca Cariate , Synthesis of the hexylamide from caffeic acid, 2011. (Co-orientador). |
| 8. |
Ola Mejza Aleksandra , Follow up and participation within the ongoing PhD activities “Design, synthesis and structure-activity studies of steroidal
inhibitors of aromatase and 5a-reductase as anti-tumors”, 2011. (Co-orientador). |
| 9. |
Rita Martins , Synthesis of potential inhibitors of 5a-reductase, 2010. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador). |
| 10. |
David Preece , Follow up and participation within the ongoing PhD activities “Design, synthesis and structure-activity studies of steroidal
inhibitors of aromatase and 5a-reductase as anti-tumors”, 2010. (Co-orientador). |
| 11. |
Carlos André Araújo Duarte Monteiro , Synthesis of potential inhibitors of 5a-reductase, 2010. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador). |
| 12. |
Joana Baptista , Synthesis and characterization of phenolic amides with potential activity in breast cancer, 2009. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador). |
| 13. |
Cátia Martins Tomé, Synthesis of amides with potential activity against dengue disease, 2009. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador). |
| 1. |
Pedro Manuel Duarte Ribeiro, Design, synthesis and biochemical studies of 17-carboxamyde derivatives of formestane as aromatase inhibitors, 2014. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador). |
| 2. |
Pedro Manuel Duarte Ribeiro , Design, synthesis and biochemical studies of 17-carboxamyde derivatives of formestane as aromatase inhibitors, 2013. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador). |
| 3. |
Daniela Filipa Felício Marques , Design, synthesis and biochemical studies of 7a-vinyl derivatives of androstenedione as aromatase inhibitors, 2012. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador). |
| 4. |
Pedro Manuel Duarte Ribeiro , Design, synthesis and biochemical studies of 17-carboxamyde derivatives of formestane as aromatase inhibitors, 2012. Iniciação científica (Mestrado Integrado em Ciências Farmacêuticas) - Universidade de Coimbra (Co-orientador). |
Participação em eventos
Event participation |
Outro tipo de participação
Other kind of participation |
| 1. |
22nd Conference on Isoprenoids, 2014 (Congresso).
Nome do evento: 22nd Conference on Isoprenoids; Cidade do evento: Prague / Czech Republic. |
| 2. |
IV CEF Conference 2013, 2013 (Conferência).
Nome do evento: IV CEF Conference. |
| 3. |
5th BBBB International Conference, 2013 (Congresso).
Nome do evento: 5th BBBB International Conference. |
| 4. |
2nd Workshop on Medicinal Chemistry Drug Discovery and Development: Understanding the R&D Process, 2013 (Workshop).
|
| 5. |
European School of Medicinal Chemistry – XXXIII Advanced Course of Medicinal Chemistry and “E. Duranti” National Seminar for
PhD Students, 2013 (Outra).
|
| 6. |
Workshop in Bioinformatics, 2012 (Workshop).
|
| 7. |
XXII International Symposium on Medicinal Chemistry, 2012 (Simpósio).
|
| 8. |
Conference CEF 2012, 2012 (Conferência).
|
| 9. |
2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery, 2011 (Encontro).
|
| 10. |
Frontiers in Medicinal Chemistry Meeting, 2011 (Encontro).
|
| 11. |
Conference CEF 2011, 2011 (Conferência).
|
| 12. |
4th BBBB – Bled International Conference on Pharmaceutical Sciences, 2011 (Conferência).
|
| 13. |
XXI International Symposium on Medicinal Chemistry, 2010 (Simpósio).
|
| 14. |
10th International Aromatase Meeting, 2010 (Encontro).
|
| 15. |
Conference CEF 2010, 2010 (Conferência).
|
| 16. |
Course of administration of vaccines, 2008 (Outra).
|
| 17. |
1st Iberic Meeting on Medicinal Chemistry – Anticancer Agents, 2007 (Encontro).
|
| 18. |
XII Annual Symposium: Paediatrics and Geriatrics – the role of the pharmacist, 2006 (Simpósio).
|
| 19. |
Annual Scientific Conference: Clinical Trial Management – Global Strategies for a Global World, 2006 (Conferência).
|
| 20. |
Homogeneous Catalysis Coimbra Course, 2004 (Outra).
|
| 21. |
Symposium: Generics, towards a future without doubts, 2002 (Simpósio).
|
Indicadores de produção
(Production indicators)
Produção científica
Scientific production |
Produção técnica
Technical production |
Dados complementares
data |
Produção científica
Scientific production |
24 |
Artigos científicos em revistas
Papers in periodics |
9 |
Com arbitragem científica
With scientific refereeing |
1 |
Sem arbitragem científica
Without scientific refereeing |
8 |
Trabalhos em eventos
Papers in conference proceedings |
15 |
Com arbitragem científica
With scientific refereeing |
1 |
Sem arbitragem científica
Without scientific refereeing |
14 |
Produção técnica
Technical production |
60 |
Outros tipos de produção técnica
Other technical production |
60 |
Dados complementares
(Additional data) |
42 |
Orientações
Orientations |
21 |
Participação em Eventos
Event participation |
21 |
|
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