José Miguel Gomes Moreira Pêgo
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Data da última atualização
»Last update
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28/12/2012 |
Dados pessoais (Personal data)
Nome completo
Full name |
José Miguel Gomes Moreira Pêgo |
Nome em citações bibliográficas
Quoting name |
Pêgo, José Miguel |
Categoria profissional
Position |
Professor Auxiliar |
Domínio científico de atuação
Scientific domain |
Ciências Médicas-Medicina Básica.
Ciências Naturais-Ciências Biológicas.
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Endereço profissional
Professional address |
Universidade do Minho
Escola de Ciências da Saúde
Instituto de Investigação em Ciências da Vida e Saúde
Escola de Ciências da Saúde - Universidade do Minho - Campus de Gualtar
Gualtar
4710-057 Braga
Portugal
Telefone: (+351)253604930Extensão: 604930
Fax: (+351)253604809
Correio electrónico: jmpego@ecsaude.uminho.pt
Homepage: www.ecsaude.uminho.pt |
Sexo
Gender |
Masculino»Male |
Graus Académicos
(Academic Degrees)
| 2004-2008 |
Doutoramento
Phd |
Ciências da Saúde - Ciências Biológicas e Biomédicas.
Universidade do Minho,
Portugal.
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| 1995-2001 |
Licenciatura
Licentiate degree |
Medicina
(6 anos » years)
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Universidade do Porto,
Portugal.
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Formação complementar ( studies)
| 2009-2009 |
Especialização/ Pós-Graduação
Specialization/ Postgraduation |
Laboratory Animal Science.
Universidade do Minho,
Portugal.
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| 2004-2008 |
Especialização Médica
Medical specialization |
| Hospital de São Marcos,
Portugal.
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Vínculos profissionais
(Professional Positions)
| Jan/2009-Actual |
Professor Auxiliar |
| Hospital São José de Fafe |
| Out/2008-Actual |
Assistente |
| Set/2011-Actual |
Professor Auxiliar |
| Jan/2009-Ago/2011 |
Professor Auxiliar |
| Jul/2008-Dez/2008 |
Professor Auxiliar |
| Out/2001-Jun/2004 |
Outra Situação |
| Mar/2008-Out/2008 |
Assistente |
| Jan/2001-Dez/2003 |
Interno Geral |
Atividades de Investigação e Desenvolvimento (Research and Development activities)
| Jan/2009-Actual |
Instituto de Investigação em Ciências da Vida e Saúde,Escola de Ciências da Saúde |
Linhas de investigação»Research fields:
Neurosciences |
| Jan/2009-Actual |
Instituto de Investigação em Ciências da Vida e Saúde,Escola de Ciências da Saúde |
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Atividades de Ensino (Teaching activities)
Curso»Academic program: Medicina
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Curso»Academic program: Medicina
Disciplinas lecionadas»Taught units:
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Curso»Academic program: Medicina
Disciplinas lecionadas»Taught units:
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Curso»Academic program: Medicina
Disciplinas lecionadas»Taught units:
- Sistemas Orgânicos e Funcionais(Docente)
- Biopatologia(Docente)
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Curso»Academic program: Medicina
Disciplinas lecionadas»Taught units:
- Sistemas Orgânicos e Funcionais(Monitor)
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Estágios realizados (Traineeships)
Estágios realizados»Traineeships:
- Cirurgia Geral (3 meses)
- Pediatria (3 meses)
- Medicina Interna (6 meses)
- Ginecologia e Obstetrícia (3 meses)
- Medicina Comunitária e Familiar (3 meses)
- Imagiologia (6 meses)
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Atividades de Serviços técnicos especializados (Specialized technical services activities)
| Hospital São José de Fafe |
| Mar/2008-Out/2008 |
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Serviço realizado»Executed service:
Anestesiologia |
| Jan/2004-Fev/2008 |
Escola de Ciências da Saúde |
Serviço realizado»Executed service:
Anestesiologia |
Linhas de Investigação (Research fields)
| 1. |
Neurosciences |
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Domínio Científico:
Ciências Médicas / Área Científica:
Medicina Básica.
Domínio Científico:
Ciências Naturais / Área Científica:
Ciências Biológicas.
Objectivos socio-económicos:
Protecção e promoção da saúde humana; Promoção geral dos conhecimentos.
Palavras-chave:
stress; anxiety; bed nucleus of the stria terminalis; amygdala.
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Projetos de Investigação (Research projects)
Participação como Investigador
Participation as Researcher |
2007-
Novas perspectivas neurobiológicas da depressão: para além da “hipótese neuroquímica” -New perspectives in the neurobiology of depression: beyond the “neurochemical hypothesis” |
| Referência do projeto»Project reference: PTDC/SAU-NEU/72699/2006.
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2010-2013
Análise multimodal da neurobiologia da depressão-Multimodal analysis of the neurobiology of depression |
| Referência do projeto»Project reference: PTDC/SAU-NEU/105180/2008.
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2011-2012
Projecto Estratégico - LA 26 - 2011-2012-Strategic Project - LA 26 - 2011-2012 |
| Referência do projeto»Project reference: PEst-C/SAU/LA0026/2011.
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2003-2005
Cognitive modulation of pain: interaction between the limbic system and the supraspinal pain control system-Cognitive modulation of pain: interaction between the limbic system and the supraspinal pain control system |
| Referência do projeto»Project reference: Projecto FCT nº 46399.
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Outro Tipo de Participação
Other kind of participation |
2010-2012
Neudesina - estudo da função de um novo factor neurotrófico-Neudesin - characterization of a novel neurotrophic factor |
| Referência do projeto»Project reference: PTDC/SAU-OSM/104475/2008.
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Línguas (Languages)
Compreende
Understandig |
Português (Bem), Inglês (Bem), Espanhol (Bem), Francês (Bem). |
Fala
Speaking |
Português (Bem), Inglês (Bem), Espanhol (Bem), Francês (Pouco). |
Lê
Reading |
Português (Bem), Inglês (Bem), Espanhol (Bem), Francês (Bem). |
Escreve
Writing |
Português (Bem), Inglês (Bem), Espanhol (Pouco), Francês (Pouco). |
Prémios e títulos (Awards Prizes, and Honours)
| 2003 |
Prémio Grünenthal Dor,
Fundação Grünenthal .
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| 2007 |
Prémio Grünenthal Dor,
Fundação Grünenthal .
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Membro de Associações Profissionais/Científicas (Professional/Scientific Association membership)
| Abr/2012 - Actual |
Simulation in Healthcare, Membro.
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| Mar/2012 - Actual |
Society in Europe for Simulation Applied to Medicine, Membro.
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| Out/2011 - Actual |
Sociedade Portuguesa de Simulação Aplicada às Ciências da Saúde, Membro fundador.
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| Fev/2011 - Actual |
European Board of Medical Assessors, Membro.
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| Set/2010 - Actual |
European Society of Anesthesiologists, Membro.
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| Mar/2008 - Actual |
Society for Neuroscience, Membro.
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| Mar/2008 - Actual |
Committee for European Education in Anaesthesiology (Portugal), Membro.
Member of the Scientific Council.
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Produção científica, técnica e artística/cultural
(Scientific, technical and artistical/cultural
production)
Capítulos de livros publicados
Published book chapters |
| 1. |
 Pêgo, José M; Sousa, Nuno; Sousa, João C; Almeida, Osborne F. X. 2010. Stress and the Neuroendocrinology of Anxiety Disorders. In Behavioral Neurobiology of Anxiety and Its Treatment, ed. Stein, Murray B.; Steckler, Thomas, 97 - 120. ISBN: 978-3-642-02911-. Berlin Heidelber: Springer-Verlag.
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| 2. |
Pêgo, José M; Sousa, Nuno; Almeida, Osborne F. X. 2005. The cellular biology of the stress response. In Handbook of Stress and the Brain , ed. T. Steckler, N.H. Kalin & J.M.H.M. Reul, 10000 - 10001. ISBN: 978-0-444-51822-4. Amsterdam: Elsevier Science Title.
Description
The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system;
how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception
of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook
comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The
work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide
a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in
this field of scientific inquiry.
Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine
and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation
and emotionality.
Part 2 treats the complexity of short-term and long-term regulation of stress responsivity, the role of stress in psychiatric
disorders as based on both preclinical and clinical evidence, and the current status with regard to new therapeutic strategies
targetting stress-related disorders.
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Artigos em revistas com arbitragem científica
Papers in periodics with scientific refereeing |
| 1. |
Batalha, V L; Pego, J M; Fontinha, B M; Costenla, A R; Valadas, J S; Baqi, Y; Radjainia, H; Müller, C E; Sebastião, A M; Lopes, L V. 2012. "Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation", Molecular Psychiatry, x: 0 - 0.
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| 2. |
Ventura-Silva, Ana P; Pêgo, José M; Sousa, João C; Marques, Ana R; Rodrigues, Ana J; Marques, Fernanda; Cerqueira, João J; Almeida, Osborne F. X; Sousa, Nuno. 2012. "Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode", European Journal of Neuroscience 36, 10: 3396 - 3406.
The bed nucleus of the stria terminalis (BNST) is critically implicated in anxiety behavior and control of the hypothalamus
pituitary adrenal axis. Having previously shown that chronic stress triggers dendritic/synaptic remodeling in specific nuclei
of the BNST, we characterised the pattern of activation of neurons within different regions of the BNST under basal conditions
and after an anxiogenic stimulus in control and stressed rats. Under basal conditions, stressed, but not control, animals
displayed increased cFOS expression in the dorsomedial nucleus and decreased activation of the principal nucleus. This pattern
resembled that observed in controls that had been exposed to the anxiogenic stimulus. Subsequent analysis of various BNST
subnuclei revealed differential patterns of gene expression in controls and stressed animals. We found decreased levels of
corticotropin-releasing hormone 1 receptor mRNA expression in the dorsomedial and fusiform nuclei, and a global increase in
the levels of corticotropin-releasing hormone 2 receptor in the principal nucleus. In addition, we found subnuclei-specific
increases in GABAA and NR2B receptors in stressed animals, which suggest changes in the GABAergic and glutamergic innervation
of the BNST. Importantly, these findings were associated with increased anxiety-like behavior and impaired control of the
hypothalamus pituitary adrenal axis in stressed animals. In summary, these data reveal that chronic stress shifts the pattern
of response of the BNST to an anxiogenic mode and provide new information on the underlying mechanisms of the stress-induced
hypercorticalism and hyperanxious status.
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| 3. |
Pêgo, José M; Sousa, Nuno; Cerqueira, João J; Leão, Pedro; Oliveira, M.; Rodrigues, Ana J. 2011. "Programming Effects of Antenatal Corticosteroids Exposure in Male Sexual Behavior.", The Journal of Sexual Medicine, 10000: 10000 - 10001.
Introduction. Brain regions implicated in sexual behavior begin to differentiate in the last trimester of gestation. Antenatal
therapy with corticosteroids is often used in clinical practice during this period to accelerate lung maturation in preterm-risk
pregnancies. Clinical and animal studies highlighted major behavioral impairments induced later in life by these treatments,
especially when synthetic corticosteroids are used. Aim. To evaluate the implications of acute prenatal treatment with natural
vs. synthetic corticosteroids on adult male rat sexual behavior and its neurochemical correlates. Methods. Twelve pregnant
Wistar rats were injected with dexamethasone (DEX-1 mg/kg), corticosterone (CORT-25 mg/kg), or saline on late gestation (pregnancy
days 18 and 19). Following this brief exposure to corticosteroids, we assessed the sexual behavior of the adult male progeny
and subsequently associated these behaviors with the levels of catecholamines and mRNA of dopamine and androgen receptors
(AR) in brain regions relevant for sexual behavior. Main Outcome Measures. Sexual behavior of adult male offspring was assessed
by exposure to receptive females. This was associated with serum testosterone levels and levels of catecholamines (determined
by high-performance liquid chromatography) and dopamine and AR mRNA expression (real-time polymerase chain reaction [PCR])
in brain regions implicated in sexual behavior. Results. Prenatal DEX exposure resulted in a decreased number and increased
mounts and intromissions latencies in adulthood. These findings were associated with decreased levels of serum testosterone
and increased hypothalamic expression of AR mRNA. DEX animals also displayed lower dopamine levels and higher dopamine receptor
mRNA expression both in hypothalamus and nucleus accumbens (NAcc). The milder phenotype of CORT animals was associated only
with decreased dopamine levels in NAcc. Conclusion. Antenatal corticotherapy programs adult male sexual beha.
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| 4. |
Oliveira, Mário; Rodrigues, Ana-João; Leão, Pedro; Cardona, Diana; Pêgo, José M; Sousa, Nuno. 2011. "The bed nucleus of stria terminalis and the amygdala as targets of antenatal glucocorticoids: implications for fear and anxiety
responses", Psychopharmacology 220, 3: 443 - 453.
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| 5. |
Rodrigues, A J; Leão, P; Pêgo, J M; Cardona, D; Carvalho, M M; Oliveira, M; Costa, B M; Carvalho, A F; Morgado, P; Araújo, D; Palha, J A; Almeida, O F. X; Sousa, N. 2011. "Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids", Molecular Psychiatry, x: 0 - 0.
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| 6. |
Bessa, João M; Mesquita, Ana R; Oliveira, Mário; Pêgo, José M; Cerqueira, João J; Palha, Joana A; Almeida, Osborne F. X; Sousa, Nuno. 2009. "A trans-dimensional approach to the behavioral aspects of depression", Frontiers in Behavioral Neuroscience 3, 1: 1 - 7.
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| 7. |
Rolanda, Carla; Lima, E.; Silva, D.; Moreira, I.; Pêgo, José M; Macedo, G.; Correia-Pinto, J.. 2009. "Invivo assessment of gastrotomy closure with over-the-scope clips in an experimental model for varicocelectomy (with video).", GastrointestEndosc 70, 6: 1137 - 1145.
Abstract BACKGROUND: Gastrotomy closure remains the major limiting factor for human translation of transgastric surgery; the
over-the-scope clip (OTSC) system was proposed as a possibility for this purpose. Transgastric access is good for a pelvic
approach, making varicocelectomy a possible indication for natural orifice transluminal endoscopic surgery (NOTES). OBJECTIVE:
To evaluate the reliability of the OTSC system in vivo after transgastric testicular vessel ligation (varicocelectomy model).
DESIGN: There were 3 experimental groups (5 animals in each): groups 1 and 3, gastrotomy dilation up to 18 mm, surgery was
performed with a double-channel endoscope; group 2, gastrotomy dilation up to 13 mm, surgery was performed with a single-channel
endoscope. SETTING: Surgical Sciences Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health
Sciences, University of Minho, Braga, Portugal. INTERVENTIONS: Bilateral testicular vessel ligation by transgastric access.
Gastrotomy closed with the largest version of OTSC system (12 mm): a single clip in groups 1 and 2, and 2 clips in group 3.
Animals were monitored for 2 weeks, killed, and submitted for necropsy. MAIN OUTCOME MEASUREMENTS: Adequacy of closure and
healing after the use of the OTSC system. Statistical analysis. RESULTS: Vessel ligation was easily achieved in all groups.
Although differences in the complication rate did not reach statistical significance (P = .099), there was a clear tendency
for a better prognosis in groups 2 and 3 than group 1. In fact, only 2 animals from group 1 had complications related to incomplete
gastrotomy closure. LIMITATIONS: Small number of animals per group; nonrandomized study. CONCLUSIONS: The OTSC system was
shown to be easy and efficient for gastrotomy closure in a survival experimental model of varicocelectomy, when correctly
matching the gastrotomy size with the clip size and/or number.
IF = 6,713.
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| 8. |
Pêgo, José M; Sousa, Nuno; Leão, Pedro; Pinto-Ribeiro, Filipa; Almeida, Armando. 2009. "Antinociception induced by chronic glucocorticoid treatment is correlated to local modulation of spinal neurotransmitter content.", Molecular Pain, 5: 41 - 52.
While acute effects of stress on pain are well described, those produced by chronic stress are still a matter of dispute.
Previously we demonstrated that chronic unpredictable stress results in antinociception in the tail-flick test, an effect
that is mediated by increased levels of corticosteroids. In the present study, we evaluated nociception in rats after chronic
treatment with corticosterone (CORT) and dexamethasone (DEX) in order to discriminate the role of each type of corticosteroid
receptors in antinociception. Results Both experimental groups exhibited a pronounced antinociceptive effect after three
weeks of treatment when compared to controls (CONT); however, at four weeks the pain threshold in CORT-treated animals returned
to basal levels whereas in DEX-treated rats antinociception was maintained. In order to assess if these differences are associated
with altered expression of neuropeptides involved in nociceptive transmission we evaluated the density of substance P (SP),
calcitonin gene-related peptide (CGRP), somatostatin (SS) and B2-¿-aminobutiric acid receptors (GABAB2) expression in the
spinal dorsal horn using light density measurements and stereological techniques. After three weeks of treatment the expression
of CGRP in the superficial dorsal horn was significantly decreased in both CORT and DEX groups, while GABAB2 was significantly
increased; the levels of SP for both experimental groups remained unchanged at this point. At 4 weeks, CGRP and SP are reduced
in DEX-treated animals and GABAB2 unchanged, but all changes were restored to CONT levels in CORT-treated animals. The expression
of SS remained unaltered throughout the experimental period. Conclusion These data indicate that corticosteroids modulate
nociception since chronic corticosteroid treatment alters the expression of neuropeptides involved in nociceptive transmission
at the spinal cord level. As previously observed in some supraspinal areas, the exclusive GR ac
IF = 4,187.
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| 9. |
Pêgo, José M; Salgado, António; Sousa, Nuno; Malva, João O; Sousa, R A; Fraga, Joana S; Silva, B A; Neves, N M; Reis, Rui L. 2009. "Effects of Starch/ Polycaprolactone-based Blends for Spinal Cord Injury Regeneration in Neurons/Glial Cells Viability and
Proliferation ", Journal of Bioactive and Compatible Polymers 24, 3: 235 - 248.
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| 10. |
Gonçalves, Leonor; Silva, Rui; Pinto-Ribeiro, Filipa; Pêgo, José M; Bessa, João M; Pertovaara, Antti; Sousa, Nuno; Almeida, Armando. 2008. "Neuropathic pain is associated with depressive behaviour and induces neuroplasticity in the amygdala of the rat", Experimental Neurology 213, 1: 48 - 56.
IF = 3,974.
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| 11. |
Lima, Estevão; Rolanda, Carla; Osório, Luís; Pêgo, José M; Silva, David; Henriques-Coelho, Tiago; Carvalho, José L; Bergström, Maria; Park, Per-Ola; Mosse, Charles A; Swain, Paul; Correia-Pinto, Jorge. 2008. "Endoscopic Closure of Transmural Bladder Wall Perforations", European Urology 178, 6: 2648 - 54.
IF = 6,512.
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| 12. |
Pêgo, José M; Morgado, P; Pinto, L G; Cerqueira, João J; Almeida, Osborne F. X; Sousa, N. 2008. "Dissociation of the morphological correlates of stress-induced anxiety and fear", The European Journal of Neuroscience 27, 6: 1503 - 16.
IF = 3,385.
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| 13. |
Lima, Estevão; Henriques-Coelho, Tiago; Rolanda, Carla; Pêgo, José M; Silva, David; Carvalho, José L; Correia-Pinto, Jorge. 2007. "Transvesical thoracoscopy: a natural orifice translumenal endoscopic approach for thoracic surgery", Surgical Endoscopy 21, 6: 854 - 8.
IF = 2,242.
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| 14. |
Lima, Estevão; Rolanda, Carla; Pêgo, José M; Henriques-Coelho, Tiago; Silva, David; Osório, Luís; Moreira, Ivone; Carvalho, José L; Correia-Pinto, Jorge. 2007. "Third-generation nephrectomy by natural orifice transluminal endoscopic surgery", The Journal of Urology 178, 6: 2648 - 54.
IF = 3,952.
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| 15. |
Mesquita, A R; Pêgo, José M; Summavielle, T; Maciel, P; Almeida, Osborne F. X; Sousa, N. 2007. "Neurodevelopment milestone abnormalities in rats exposed to stress in early life", Neuroscience 147, 4: 1022 - 33.
IF = 3,352.
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| 16. |
Rolanda, Carla; Lima, Estevão; Pêgo, José M; Henriques-Coelho, Tiago; Silva, David; Moreira, Ivone; Macedo, Guilherme; Carvalho, José L; Correia-Pinto, Jorge. 2007. "Third-generation cholecystectomy by natural orifices: transgastric and transvesical combined approach (with video)", Gastrointestinal Endoscopy 65, 1: 111 - 7.
IF = 5,888.
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| 17. |
Lima, Estevão; Rolanda, Carla; Pêgo, José M; Henriques-Coelho, Tiago; Silva, David; Carvalho, José L; Correia-Pinto, Jorge. 2006. "Transvesical endoscopic peritoneoscopy: a novel 5 mm port for intra-abdominal scarless surgery", The Journal of Urology 176, 2: 802 - 5.
IF = 3,956
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| 18. |
Oliveira, Mário; Bessa, João M; Mesquita, Ana R; Tavares, Hugo; Carvalho, André; Silva, Rui; Pêgo, José M; Cerqueira, João J; Palha, Joana A; Almeida, Osborne F. X; Sousa, Nuno. 2006. "Induction of a hyperanxious state by antenatal dexamethasone: a case for less detrimental natural corticosteroids", Biological Psychiatry 59, 9: 844 - 52.
IF = 7,154.
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| 19. |
Pêgo, José M; Morgado, P; Cerqueira, João J; Almeida, Osborne F. X; Sousa, N. 2006. "Mismatch between anxiety status and morphometric parameters in the amygdala and bed nucleus of the stria terminalis", Behavioural Brain Research 173, 2: 320 - 5.
IF = 2,591.
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| 20. |
Cerqueira, João J; Pêgo, José M; Taipa, Ricardo; Bessa, João M; Almeida, Osborne F. X; Sousa, Nuno. 2005. "Morphological correlates of corticosteroid-induced changes in prefrontal cortex-dependent behaviors", The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 25, 34: 7792 - 800.
IF = 7,506.
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| 21. |
Pinto-Ribeiro, F; Almeida, Armando; Pêgo, José M; Cerqueira, João J; Sousa, Nuno. 2004. "Chronic unpredictable stress inhibits nociception in male rats", Neuroscience Letters 359, 1-2: 73 - 76.
IF = 2,019.
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Trabalhos completos/resumidos em eventos com arbitragem científica
Papers in conference proceedings with scientific refereeing |
| 1. |
Pêgo, José M; Salgado, António; Carvalho, Miguel M; Campos, Filipa; Bessa, João M; Cerqueira, João J; Sousa, Nuno; Baltazar, G. 2011. "A Behavioral Characterization on the Motor and Emotional Deficits of the 6-OHDA Parkinson Disease Rat Model", Trabalho apresentado em 12th Meeting of the Portuguese Society for Neurosciences, In 12th Meeting of the Portuguese Society for Neurosciences, Lisboa.
Parkinson’s disease (PD) is a neurodegenerative condition affecting the dopaminergic system, causing the emergence of both
motor and non-motor complications. The development of animal models mimicking this condition brought new insights regarding
the neuropathologic mechanisms of this disease, and endowed us with suitable tools to develop new therapeutical strategies.
One of the most widely used models is the unilaterally 6-OHDA-lesioned rat model, characterized by a biased rotatory behavior
after apomorphine/methamphetamine challenge. However, little is known about other behavioral features of this model, particularly
at the emotional/cognitive level. Importantly, this model has been extensively used to assess the therapeutical relevance
of novel treatments, particularly at the motor level. The improvement of the behavioral characterization of this model could
reveal additional features besides the motor deficits, which could in the future be useful to address treatment-related improvements
in a multidimensional fashion.
Therefore, the objective of the present work was to pursue a more thorough behavioral characterization of this model, particularly
at the emotional and cognitive levels. We believe that our findings can be highly relevant for the validity of this model
in PD regenerative medicine.
Wistar-Han rats were unilaterally injected with 6-OHDA or saline in the medial forebrain bundle (coordinates related to bregma,
AP= -4,4mm; ML= -1,0mm; DV= -7,8mm). Behavioral assessment was done using: rotorod, elevated plus maze (EPM), acoustic startle
(AS), Morris water maze (MWM), open field (OF), forced swimming test (FST), sucrose preference test (SPT) and rotameter (apomorphine-derived
rotatory behavior assessment). Tyrosine hydroxylase immunohistochemistry was performed to assess the effectiveness of the
lesion.
Lesioned animals displaying apomorphine induced rotatory behavior had severe dopaminergic degeneration. In this group of animals,
it was poss. |
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| 2. |
Pêgo, José M; Sousa, Nuno; Almeida, Osborne F. X; Cerqueira, João J; Morgado, P. 2007. "Chronic Stress Associated Anxiety Correlates With Morphological Changes in Bed Nucleus of Stria Terminalis But Not Amygdala", Trabalho apresentado em 10th Meeting of the Portuguese Society for Neurosciences, In 10th Meeting of the Portuguese Society for Neurosciences, Ofir. |
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| 3. |
Pêgo, José M; Sousa, Nuno; Cerqueira, João J; Almeida, Osborne F. X; Morgado, P.. 2007. "Chronic Stress Induced Anxiety-like Behavior Does Not Correlate with Structural Changes in Pyramidal Neurons of Basolateral
Amygdala", Trabalho apresentado em 10th Meeting of the Portuguese Society for Neurosciences, In 10th Meeting of the Portuguese Society for Neurosciences, Ofir. |
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| 4. |
Pêgo, José M; Almeida, Osborne F. X; Sousa, Nuno; Mesquita, Ana R; Summavielle, Teresa. 2007. "Neurodevelopment Milestone Abnormalities in rats Exposed to Stress in Early Life", Trabalho apresentado em 10th Meeting of the Portuguese Society for Neurosciences, In 10th Meeting of the Portuguese Society for Neurosciences, Ofir. |
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Curso de curta duração lecionado
Taught short course |
| 1. |
Pêgo, José M. InAnestesia - Introdução à Anestesiologia Clínica, 2011 (Aperfeiçoamento), promovido por Escola de Ciências da Saúde.
Duração: 5 dias. Local: Universidade do Minho, Cidade: Braga, Tipo de participação: Organizador.
A Anestesiologia é uma área científica da Medicina pouco representada na maioria dos curricula das escolas médicas e, por
isso, de pouca familiaridade no final da Formação Pré-graduada e Internato do Ano Comum. Com o intuito de colmatar esta ausência
e permitir uma transição menos abrupta foi idealizado um curso de iniciação à Anestesiologia Clínica – InAnestesia. O curso
foi dirigido aos internos do primeiro ano de especialidade, durante a primeira semana de trabalho e pretendeu criar um ambiente
de introdução à prática da Anestesiologia. Os aspectos formativos do curso, englobaram fundamentos teóricos, básicos à prática
da Anestesiologia, apresentados sob a forma de sessões teóricas, e fundamentos práticos com recurso a simuladores, onde os
internos puderam aprender e treinar gestos clínicos da prática diária dos anestesiologistas que, na globalidade, consideramos
essenciais para os primeiros passos na especialidade.
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| 2. |
Pêgo, José M. Fisiologia Cardiovascular, 2010 (Aperfeiçoamento), promovido por Committee for European Education in Anaesthesiology (Portugal),.
Duração: 25 dias., Tipo de participação: Docente.
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Organização de evento
Event organization |
| 1. |
Pêgo, José M. Congresso da Sociedade Portuguesa de Neurociências,2009 (Congresso / Organização). |
Curso de curta duração
Short duration course |
| 1. |
Pêgo, José M. InAnestesia - Introdução à Anestesiologia Clínica,2011 (Especialização).
A Anestesiologia é uma área científica da Medicina pouco representada na maioria dos curricula das escolas médicas e, por
isso, de pouca familiaridade no final da Formação Pré-graduada e Internato do Ano Comum. Com o intuito de colmatar esta ausência
e permitir uma transição menos abrupta foi idealizado um curso de iniciação à Anestesiologia Clínica – InAnestesia. O curso
foi dirigido aos internos do primeiro ano de especialidade, durante a primeira semana de trabalho e pretendeu criar um ambiente
de introdução à prática da Anestesiologia. Os aspectos formativos do curso, englobaram fundamentos teóricos, básicos à prática
da Anestesiologia, apresentados sob a forma de sessões teóricas, e fundamentos práticos com recurso a simuladores, onde os
internos puderam aprender e treinar gestos clínicos da prática diária dos anestesiologistas que, na globalidade, consideramos
essenciais para os primeiros passos na especialidade. |
Dados Complementares (Additional data)
Tese de Doutoramento
Phd Thesis |
| 1. |
António Manuel Melo Soares de Almeida, General anesthetics effects in cognitive modulation, 2010. Tese (Medicina) - Universidade do Porto, Bolseiro(a) de Fundação Calouste Gulbenkian (Co-orientador).
Billions of patients worldwide have already been anaesthesized. Each year 200 millions of patients are anesthetized. The aim
of anaesthesia is to achieve the conditions to perform a diagnostic or therapeutic intervention in the patient without inducing
physiological and psychological stress. There exist Clinical evidences of postoperative cognitive change. In vivo studies
also shown cognitive and molecular changes induced by GA exposure. The aim of this project is to determine the effects of
GA in cognitive flexibility. Studies suggest changes both in long term cellular protein expression, and impairment in striatal
dopaminergic after GA exposure. For the purpose we will expose rodents to GA to try to assess changes in cognition processes
related to cortico-basal ganglia network. |
| 2. |
Ana Paula Ventura da Silva, Molecular and functional correlates of stress-related anxiety, 2009. Tese (Ciências da Saúde - Ciências Biológicas e Biomédicas) - Universidade do Minho, Bolseiro(a) de Universidade do Minho (Orientador). |
Dissertação de Mestrado
Master degree dissertation |
| 1. |
Ana Rita Fernandes Marques, In vivo studies of changes induced by chronic stress in the physiological proprieties of neurons involved in the brain circuitries
underlying anxiety, 2010. Dissertação (Neurociências) - Universidade do Minho, Bolseiro(a) de Fundação para a Ciência e a Tecnologia (Orientador).
Anxiety disorders affect a large portion of the world population and are frequently long-lasting and debilitating. Chronic
stress plays an important role in their etiology. Several studies have shown that animals exposed to chronic unpredictable
stress (CUS) present anxiety-like behavior correlated with hypothalamic–pituitary–adrenal (HPA) axis dysfunction and structural
changes in the brain, principally in limbic structures.
The mechanisms by which chronic stress alters central circuits that mediate anxiety-like emotional behavior are still largely
unknown. Substantial evidence has implicated the bed nucleus of the stria terminalis (BST) in the regulation of the HPA axis,
acting as a relay nucleus between limbic structures and the hypothalamic paraventricular nucleus (PVN). This is enhanced by
previous results showing a hypertrophy of dendrites and spine sprouting in the BST anterodivision after CUS exposure. Nevertheless
it is not known if the stress-induced structural and behavioral changes are associated with an altered pattern of activation
in the BST. To address this question, electrophysiological studies will be conducted in stressed and control animals. A CUS
paradigm will be used to induce anxiety-like behavior in rats, which will be evaluated in three different tests: open field,
elevated plus maze and acoustic startle. Electrophysiological proprieties of single cell units in dorsomedial/fusiform and
principal BST subnuclei of both stressed and control animals will be recorded in basal conditions. Afterwards BST spontaneous
and sonorous-evoked activity will be recorded immediately after manipulation of central nucleus amygdala, in order to see
the role of amygdala inputs over BST.
. |
Trabalho de conclusão de curso de Bacharelato/Licenciatura
Bachelor/Licenciate degree conclusion work |
| 1. |
Dânia Marlene de Sousa Moreira, Tradução Especializada na Área da Medicina com base no Dicionário Pschyrembel Klinisches Woerterbuch, 2009. Trabalho de Conclusão de Curso (Licenciatura em Licenciatura em Línguas Estrangeiras Aplicadas) - Universidade do Minho (Co-orientador). |
| 2. |
Sofia Maria da Costa Mesquita Guimarães, Tradução Especializada na Área da Medicina: Doenças Neurológicas, 2009. Trabalho de Conclusão de Curso (Licenciatura em Licenciatura em Línguas Estrangeiras Aplicadas) - Universidade do Minho. |
| 3. |
Marlene Oliveira da Silva, Tradução Especializada na Área da Medicina com base no Dicionário Pschyrembel Klinisches Woerterbuch, 2009. Trabalho de Conclusão de Curso (Licenciatura em Licenciatura em Línguas Estrangeiras Aplicadas) - Universidade do Minho (Orientador). |
Participação no júri de Graus Académicos
Academic Degrees jury participation |
| 1. |
José Miguel Pêgo; José Henrique Dias Pinto de Barros; Jorge Manuel Mergulhão de Castro Tavares; Pedro Augusto de Melo Lopes Ferreira; Carla Maria de Moura Lopes; Ana Azevedo Cardoso de Oliveira. Participação no júri de Fernando José Pereira Alves Abelha. Outcome in surgical cricital care patients, 2010. Tese (Medicina) - Universidade do Porto. |
| 2. |
José Miguel Pêgo; Leão, Cecília; Isaura Tavares; Armando Almeida; Antti Pertovaara; Andrew Rice. Participação no júri de Maria Leonor Barbosa Gonçalves. Plasticity of the pain control system induced by neuropathic pain: the amygdala-medulla system, 2009. Tese (Ciências da Saúde - Ciências Biológicas e Biomédicas) - Universidade do Minho.
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| 3. |
José Miguel Pêgo; Nuno Sousa; Leão, Cecília; Tavares, Amélia; Leonard, Brian. Participação no júri de Ana Raquel Marcelino Mesquita. An integrative biological assessment of the programming effects of glucocorticoids upon the developing brain: Insights on
their relevance for future psychiatric pathologies, 2008. Tese (Ciências da Saúde - Ciências Biológicas e Biomédicas) - Universidade do Minho.
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| 1. |
Pêgo, José Miguel; Jorge Manuel Mergulhão de Castro Tavares; Joaquim Viana. Participação no júri de Sofia Gabriela Afonso Afonso Reis Serra. Avaliação do Consumo de desflurano nos doentes com monitorização da profundidade anestésica através do índice biespectral:
estudo comparativo com a monitorização baseada em parâmetros clínicos., 2009. Dissertação (Anestesiologia e Terapêutica da Dor) - Universidade de Coimbra. |
| 2. |
Pêgo, José Miguel; Maria Filomena Trabucho Caeiro; Rui Artur Manuel dos Santos Malhó; Maria Tuna Oliveira Brites. Participação no júri de Eduarda Cristina Duarte Magalhães Coutinho. Neuronal Cytoskeletal Dynamic Modification Induced by Unconjugated Bilirubin, 2009. Dissertação (Biologia Molecular e Humana) - Universidade de Lisboa.
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Bacharelato/Licenciatura
Degree of licentiate |
| 1. |
José Miguel Pêgo; Mário Matos; Cláudia Breitbarth. Participação no júri de Marlene Oliveira da Silva. Tradução Especializada nas Ciências da Saúde com base no dicionário Pschyrembel Klinisches Woerterbuch, 2009. Trabalho de Conclusão de Curso (Bacharelato/Licenciatura em Licenciatura em Línguas Estrangeiras Aplicadas) - Universidade do Minho. |
| 2. |
José Miguel Pêgo; Cláudia Breitbarth; Mário Matos. Participação no júri de Dânia Marlene de Sousa Moreira. Tradução Especializada nas Ciências da Saúde com base no dicionário Pschyrembel Klinisches Woerterbuch, 2009. Trabalho de Conclusão de Curso (Bacharelato/Licenciatura em Licenciatura em Línguas Estrangeiras Aplicadas) - Universidade do Minho. |
| 3. |
José Miguel Pêgo; Cláudia Breitbarth; Mário Matos. Participação no júri de Sofia Maria da Costa Mesquita Guimarães. Tradução Especializada nas Ciências da Saúde: doenças neurológicas, 2009. Trabalho de Conclusão de Curso (Bacharelato/Licenciatura em Licenciatura em Línguas Estrangeiras Aplicadas) - Universidade do Minho. |
Participação em eventos
Event participation |
Participação como Membro da Comissão Científica
Participation as Member of the Program Committee |
| 1. |
II Jornadas Ciência e Medicina, 2011 (Encontro).
Nome do evento: II Jornadas Ciência e Medicina - Neurociências; Nome da Instituição: NEMUM; Cidade do evento: Braga / Escola de Ciências da Saúde - Universidade do Minho. |
Outro tipo de participação
Other kind of participation |
| 1. |
Métodos de Controlo da Dor, 2011 (Workshop).
Nome do evento: Minho Medical Meeting - Perinatal; Nome da Instituição: Núcleo de Estudantes de Medicina da Universidade do Minho; Cidade do evento: Braga / Escola de Ciências da Saúde. |
| 2. |
Simulação Avançada em Anestesiologia , 2010 (Workshop).
Nome do evento: Simulação Avançada em Anestesiologia ; Nome da Instituição: Escola de Ciências da Saúde; Cidade do evento: Braga / Universidade do Minho. |
Indicadores de produção
(Production indicators)
Produção científica
Scientific production |
Produção técnica
Technical production |
Produção artística/cultural
Artistical/cultural production |
Dados complementares
data |
Produção científica
Scientific production |
27 |
Livros e capítulos
Books and book chapters |
2 |
Capítulos de livros publicados
Published book chapters |
2 |
Artigos científicos em revistas
Papers in periodics |
21 |
Com arbitragem científica
With scientific refereeing |
21 |
Trabalhos em eventos
Papers in conference proceedings |
4 |
Com arbitragem científica
With scientific refereeing |
4 |
Produção técnica
Technical production |
3 |
Outros tipos de produção técnica
Other technical production |
3 |
Produção artística/cultural
Artistical/cultural production |
1 |
Dados complementares
(Additional data) |
17 |
Orientações
Orientations |
6 |
Participação no Júri de Graus Académicos
Academic Degrees jury participation |
8 |
Participação em Eventos
Event participation |
3 |
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Visualizações do curriculum [
9649
]
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