Miguel Soares obtained his BS in biology (1990), MS in cellular biology (1994) and Ph.D. in Science (1995) from the University of Louvain in Belgium. He became a research fellow in the laboratory of Prof. Fritz H. Bach at the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA (1995 1998), then instructor in surgery (1998 2004) and lecturer (2003 2004). He moved to the Instituto Gulbekian de Ciencia, Oeiras, Portugal (2004) where he is currently a Principal Investigator. Miguel Soares is an invited professor at Lisbon Medical School, “Faculdade de Lisboa”, Portugal. The research developed by t Miguel Soares evolves around understanding the cellular and molecular mechanisms regulating inflammation and how these can be used therapeutically to overcome the pathologic outcome of immune mediated inflammatory diseases. Main original scientific contributions include: 2012: That host metabolic adaptation to tissue iron overload confers disease tolerance to systemic infections (Cell Host & Microbe 12; 5, 693-704). 2011: That the sickle hemoglobin mutation confers disease tolerance to Plasmodium infection via a mechanism involving the induction of heme oxygenase-1 enzyme and the production of the gasotransmitter carbon monoxide (CO) via heme catabolism by this enzyme (Cell, 2011, Vol. 145, Issue 3, 398-409, 29). 2007-12: That induction of heme oxygenase-1 supports the survival of an infected host irrespectively of its pathogen load. This provides the first molecular basis for disease tolerance to Plasmodium (Nature Medicine, 2007, 13: 703-10 and Proc. Natl. Acad. Sci. USA. 2009, 106; 37: 15837-42) and polymicrobial (Science TM, 2010. 2: 51) infections (Science, 2012, 335, 936). 2007-10: The gasotransmitter carbon monoxide (CO) exerts a broad range of protective effects via a mechanism involving the inhibition of heme release from hemoproteins, avoiding the deleterious effects of heme (Nature Medicine, 2007, 13:703-10 and Annu. Rev. Pharmacol. Toxicol. 2010. 50:323–54). 2001-7: The gasotransmitter carbon monoxide (CO) can be used therapeutically to prevent the progression of a broad range of immune mediated inflammatory conditions, including the rejection of transplanted organs (J. Immunol, 2001, 166, 4185-4194, Nature Medicine, 2003, 9, 183-190), arteriosclerosis (Nature Medicine, 2003, 9, 183-190), ischemia & reperfusion injury (The FASEB Journal. 2004; 18:771-772), autoimmune neuroinflammation (J. Clin. Invest. 2007, 117, 438-447) and severe forms of malaria (Nature Medicine, 2007, 13: 703-10). 1998-2001: Production of the gasotransmitter carbon monoxide (CO) via heme catabolism by heme oxygenase-1, exerts cytoprotective (J. Exp. Med., 2001, 192, 1015-25) and anti inflammatory (Nature Medicine, 2000, 6, 4, 422-428) effects. 1998: Transplanted organs can express “protective genes”, i.e. heme oxygenase-1 that prevent their own rejection (Nature Medicine, 1998; 4, 91-8).
Endereço de acesso a este CV: http://www.degois.pt/visualizador/curriculum.jsp?key=4560993892441059

Nome completo Full name	Miguel Che Parreira Soares
Nome em citações bibliográficas Quoting name	Soares, Miguel Che Parreira
Categoria profissional Position	Investigador Principal
Domínio científico de atuação Scientific domain	Ciências Naturais-Ciências Biológicas. Ciências Médicas-Medicina Básica.

Endereço profissional Professional address

Fundação Calouste Gulbenkian Instituto Gulbenkian de Ciência R da Quinta Grande, 6 Oeiras 2780-156 Oeiras Portugal Apartado: 14 Telefone: (+351)214464520 Fax: (+351)214407970 Correio electrónico: mpsoares@igc.gulbenkian.pt Homepage: http://www.igc.gulbenkian.pt/research/unit/43

Sexo Gender

Masculino»Male

1995	Doutoramento Phd
Ciências (5 anos » years) . University of Louvain, Bélgica. Instituição portuguesa que atribuiu reconhecimento/equivalência/registo » Portuguese Instituition providing acknowledgement/equivalence/registry : University of Louvain. Com o tipo » With the type: Equivalência » Equivalence.

1994	Mestrado Master degree
Biologia Celular (5 anos » years) . University of Louvain, Bélgica. Instituição portuguesa que atribuiu reconhecimento/equivalência/registo » Portuguese Instituition providing acknowledgement/equivalence/registry : University of Louvain. Com o tipo » With the type: Equivalência » Equivalence.

1990	Licenciatura Licentiate degree
Biologia (4 anos » years) . University of Louvain, Bélgica. Instituição portuguesa que atribuiu reconhecimento/equivalência/registo » Portuguese Instituition providing acknowledgement/equivalence/registry : University of Louvain. Com o tipo » With the type: Equivalência » Equivalence.

Universidade Nova de Lisboa

Jan/2003-Actual

Professor Associado

Universidade de Lisboa

Jan/2003-Actual

Outra Situação

Fundação Calouste Gulbenkian

Jan/2002-Actual

Investigador Principal

Harvard Medical School - Beth Israel Deaconess Medical Center

Jan/1998-Dez/2004

Outra Situação

Harvard Medical School - Beth Israel Deaconess Medical Center

Jan/2003-2004

Outra Situação

Harvard Medical School - Beth Israel Deaconess Medical Center

Jan/1995-1998

Outra Situação

Compreende Understandig	Português (Bem), Inglês (Bem), Francês (Bem).
Fala Speaking	Português (Bem), Inglês (Bem), Francês (Bem).
Lê Reading	Português (Bem), Inglês (Bem), Francês (Bem).
Escreve Writing	Português (Bem), Inglês (Bem), Francês (Bem).

1990	Ph.D. Fellowship , Belgium Institute for industrial and agricultural investigation (IRSIA).
2000	“Harvard Medical School Scholars in Medicine” Fellowship, Harvard Medical School .
2004	International Prize of Investigation CESPU, Cooperativa de Ensino Superior Politécnico e Universitário.
2008	NEDAI research prize in auto-immunity, Portuguese Society of Internal Medicine (SPMI).
2009	Pfizer Prize for Basic Science, Sociedade de Ciências Mêdicas de Lisboa.
2010	Ten personalities of the year 2010, Jornal Público.

2007- Actual	European Working Group of immune mediated inflammatory diseases, Member of Scientific Committee.
2003- Actual	Transplant International, the official Journal of the European Society of Organ Transplantation, member of editorial board.
2000- Actual	International Transplant Society, Membro.
2005- 2007	Basic Science Committee of European Society of Organ Transplantation (ESOT), Membro.

Capítulos de livros publicados Published book chapters

1.	Silva, G.; Gregoire, I. P; Tokaji, L.; Chora, A. A; Soares, Miguel C. P; Cavalcante, M. C. M; Seldon, M. P. 2005. Heme Oxygenase-1: A protective gene that regulates inflammation and immunity.  In Heme Oxygenase in Biology and Medicine: Emergence of the Products Carbon Monoxide, Iron and the Bile Pigments, ed. L.E. Otterbein & Brian S. Zuckerbraun, 141 - 171. . EUA: Nova Science Publishers Inc.

2.	Bach, F. H; Yamashita, K.; Ollinger, R.; Akamatsu, Y.; McDaid, J.; Otterbein, L. E; Wang, H.; Soares, Miguel C. P. 2005. Heme Oxygenase 1 (HO 1) in Transplantation.  In Heme Oxygenase in Biology and Medicine: Emergence of the Products Carbon Monoxide, Iron and the Bile Pigments", ed. L.E. Otterbein & Brian S. Zuckerbraun, 171 - 191. . EUA: Nova Science Publishers Inc.

3.	Soares, Miguel C. P; O, Berberat p; L., Gunther; S., Brouard; FH., Bach. 2002. Heme oxygenase-1 (HO-1): multiple effects of a protective gene thar prevents graft rejection..  In Heme Oxygenase in Biology and Medicine, 215 - 226. ISBN: 0306472643. Estados Unidos: Kluwer.

4.	Soares, M. P; Guenther, L.; Berberat, P. O; FH., Bach. 2002. Heme oxygenase-1 and/or carbon monoxide can promote organ graft survival.  In Disease markers in exhaled breath : basic mechanisms and clinical applications, 267 - 273. ISBN: 1-58603-273-9 . Países Baixos: IOS Press. Conference of the NATO-Advanced-Study-Institute on Disease Markers in Exhaled Breath IRAKLION, GREECE, JUN 22-JUL 01, 2002.

5.	Soares, Miguel C. P. 2001. Helix.  In Amgen Magazine of Biotechnology, 14 - 21. . USA: Amgen Magazine of Biotechnology.

6.	Berberat, P. O; Gunther, L.; Brouard, S.; Soares, Miguel C. P; Bach, F. H. 2001. Heme oxygenase-1 (HO-1): multiple effects of a protective gene that prevents graft rejection.  In Heme Oxygenase in Biology and Medicine, ed. N. G Abraham, J. Alam, K. A. Nath , 1 - 10. . EUA: Kluwer academic/plenum publishers.

7.	Gianello, P.; Soares, Miguel C. P; Latinne, D.; Bazin, H.. 1998. Xenotransplantation.  In Handbook of vertebrate immunology, ed. Pastoret P.P., Griebel P., Bazin H., Govaerts A., 619 - 635. . Berlin Heidelberg: Academic Press Springer-Verlag.

Artigos em revistas com arbitragem científica Papers in periodics with scientific refereeing

1.	Larsen, Rasmus; Gouveia, Zélia; Soares, Miguel P; Gozzelino, Raffaella. 2012. "Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases", Frontiers in Pharmacology 3, 77: 0 - 20.

2.	Oliveira, V.; Agua-Doce, A.; Duarte, J.; SoareS, M. P; Graca, L.. 2006. "Regulatory T cell maintenance of dominant tolerance: Induction of tissue self-defense?", Transplant Immunology 17, 1: 7 - 10.

3.	Silva, G.; Cunha, A.; Gregoire, I. P; Seldon, M. P; Soares, Miguel C. P. 2006. "Anti-Apoptotic Effect of Heme Oxygenase-1 in Endothelial Cells: Degradation of p38 Mitogen Activated Protein Kinase (MAPK)", The Journal of Immunology,  3, 177: 1894 - 1893.

4.	Bach, F. H; Wang, H.; Soares, M. P. 2005. "Heme oxygenase-1 (HO-1) in transplantation", Heme Oxygenase: the Elegant Orchestration of Its Products in Medicine 0, 0: 171 - 190.

5.	McDaid, J.; Yamashita, K.; Chora, A. A; Ollinger, R.; Strom, T. B; Li, X. C; Bach, F. H; Soares, M. P. 2005. "Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells", Faseb Journal 19, 1: 458 - 458.

6.	Ollinger, R.; Bilban, M.; Erat, A.; Froio, A.; McDaid, J.; Tyagi, S.; Csizmadia, E.; Graca-Souza, A. V; Liloia, A.; Soares, M. P; Otterbein, L. E; Usheva, A.; Yamashita, K.; Bach, F. H. 2005. "Bilirubin - A natural inhibitor of vascular smooth muscle cell proliferation", Circulation 112, 7: 1030 - 1038.

7.	Wang, H. J; Lee, S. S; Gao, W. D; Czismadia, E.; McDaid, J.; Ollinger, R.; Soares, M. P; Yamashita, K.; Bach, F. H. 2005. "Donor treatment with carbon monoxide can yield islet allograft survival and tolerance", Diabetes 54, 5: 1400 - 1406.

8.	Silva, G.; Gregoire, I. P; Tokaji, L.; Chora, A. A; Seldon, M. P; Cavalcante, M. C. M; Soares, M. P. 2005. "Heme oxygenase-1: A protective gene that regulates inflammation and immunity", Heme Oxygenase: the Elegant Orchestration of Its Products in Medicine 0, 0: 141 - 169.

9.	Akamatsu, Y.; Haga, M.; Tyagi, S.; Yamashita, K.; Graca-Souza, A. V; Ollinger, R.; Czismadia, E.; May, G. A; Ifedigbo, E.; Otterbein, L. E; Bach, F. H; Soares, M. P. 2004. "Heme oxygenase-1-derived carbon monoxide protects hearts from transplant-associated ischemia reperfusion injury", Faseb Journal 18, 2: 771 - 772.

10.	Soares, M. P; Seldon, M. P; Gregoire, I. P; Vassilevskaia, T.; Berberat, P. O; Yu, J.; Tsui, T. Y; Bach, F. H. 2004. "Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation", Journal of Immunology 172, 6: 3553 - 3563.

11.	Yamashita, K.; McDaid, J.; Ollinger, R.; Tsui, T. Y; Berberat, P. O; Usheva, A.; Csizmadia, E.; Smith, R. N; Soares, M. P; Bach, F. H. 2004. "Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts", Faseb Journal 18, 2: 765 - 767.

12.	G, Sass; S., Seyfried; Soares, Miguel C. P; Yamashita, K.; Kaczmarek, E.; W.L., Neuhuber. 2004. "Cooperative effect of biliverdin and carbon monoxide on survival of mice in immune-mediated liver injury", Hepatology, 5: 1128 - 1135.

13.	Soares, Miguel C. P. 2004. "VEGF: Is it just an inducer of heme oxygenase-1 expression?", Blood, 103: 751 - 751.

14.	Soares, Miguel C. P; N, Olsen. 2004. "Heme Oxygenase-1 (HO-1), a protective gene that promotes long-term survival of transplanted organs", Free Radical Biology and Medicine, Special series “Heme oxygenase in human disease". , 38: 426 - 435.

15.	Otterbein, L. E; Zuckerbraun, B. S; Haga, M.; Liu, F.; Song, R. P; Usheva, A.; Stachulak, C.; Bodyak, N.; Smith, R. N; Csizmadia, E.; Tyagi, S.; Akamatsu, Y.; Flavell, R. J; Billiar, T. R; Tzeng, E.; Bach, F. H; Choi, A. M. K; Soares, M. P. 2003. "Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury", Nature Medicine 9, 2: 183 - 190.

16.	G, Sass; Soares, Miguel C. P; Yamashita, K.; S., Seyfried; WH., Zimmermann; T., Eschenhagen; T., Ritter; HD., Volk; G., Tiegs. 2003. "Carbon monoxide generated by Heme oxygenase-1 prevents apoptotic mediated liver injury in mice", Hepatology, 38: 909 - 918.

17.	Avihingsanon, Y.; Ma, N. L; Csizmadia, E.; Wang, C.; Pavlakis, M.; Strom, T. B; Soares, M. P. 2002. "Expression of protective genes in human renal allografts: a regulatory response to injury associated with graft rejection", Transplantation 73, 7: 1079 - 1085.

18.	Soares, M. P; Brouard, S.; Smith, R. N; Bach, F. H. 2001. "Heme oxygenase-1, a protective gene that prevents the rejection of transplanted organs", Immunological Reviews 184, 184: 275 - 285.

19.	Sato, K.; Balla, J.; Otterbein, L. E; Smith, R. N; Brouard, S.; Lin, Y.; Csizmadia, E.; Sevigny, J.; Robson, S. C; Vercellotti, G.M.; Choi, A. M. K; Bach, F. H; Soares, M. P. 2001. "Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants", Journal of Immunology 166, 6: 4185 - 4194.

20.	Berberat, P. O; Gunther, L.; Brouard, S.; Soares, Miguel C. P; Bach, F. H. 2001. "Heme oxygenase-1 (HO-1): multiple effects of a protective gene that prevents graft rejection", Heme Oxygenase in Biology and Medicine, 2001: 1 - 10.

21.	Brouard, S.; Otterbein, L. E; Anrather, J.; Tobiasch, E.; Bach, F. H; Choi, A. M. K; Soares, M. P. 2000. "Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis", Journal of Experimental Medicine 192, 7: 1015 - 1025.

22.	Otterbein, L. E; Bach, F. H; Alam, J.; Soares, M. P; Lu, H.T.; Wysk, M.; Davis, R.J.; Flavell, R. J; Choi, A.M.. 2000. "Carbon monoxide mediates anti-inflammatory effects via the mitogen activated protein kinase pathway", Nature Medicine 6, 4: 422 - 428.

23.	Lin, Y.; Soares, M. P; Smith, N. R; Czismadia, E.; Bach, F. H. 2000. "Long-term survival of hamster hearts in pre-sensitized rats", Journal of Immunology, 164: 4883 - 4892.

24.	Soares, M. P; Ferran, C.; Sato, K.; Takigami, K.; Anrather, J.; Lin, Y.; FH., Bach. 2000. "Protective responses of endothelial cells", Genes and Resistance to Disease, -: 91 - 103.

25.	Anrather, J.; Csizmadia, V.; Soares, M. P; Winkler, H.. 1999. "Regulation of NF-kappa B RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase C zeta in primary endothelial cells", Journal of Biological Chemistry 274, 19: 13594 - 13603.

26.	Sato, K.; Takigami, K.; Miyatake, T.; Czismadia, E.; Latinne, D.; Bazin, H.; Bach, F. H; Soares, M. P. 1999. "Suppression of delayed xenograft rejection by specific depletion of elicited antibodies of the IgM isotype", Transplantation 68, 6: 844 - 854.

27.	Soares, M. P; Lin, Y.; Sato, K.; Stuhlmeier, K. M; Bach, F. H. 1999. "Accommodation", Immunology Today 20, 10: 434 - 437.

28.	Soares, M. P; Bach, F. H. 1999. "C1q receptors and endothelial cell activation", Journal of Laboratory and Clinical Medicine 133, 6: 520 - 522.

29.	Soares, Miguel C. P; Lin, Y.; Sato, K.; Anrather, J.; Takigami, K.; Ferran, C.; Robson, S. C; Bach, F. H. 1999. "Pathogenesis of and potential therapies for delayed xenograft rejection", Current Opinion in Organ Transplantation, 4: 80 - 89.

30.	Koyamada, N.; Miyatake, T.; Candinas, D.; Mark, W.; Hechenleitner, P.; Hancock, W. W; Soares, M. P; Bach, F. H. 1998. "Transient complement inhibition plus T-cell immunosuppression induces long-term survival of mouse-to-rat cardiac xenografts", Transplantation 65, 9: 1210 - 1215.

31.	Miyatake, T.; Sato, K.; Takigami, K.; Koyamada, N.; Hancock, W. W; Bazin, H.; Latinne, D.; Bach, F. H; Soares, M. P. 1998. "Complement-fixing elicited antibodies are a major component in the pathogenesis of xenograft rejection", Journal of Immunology 160, 8: 4114 - 4123.

32.	Soares, Miguel C. P; Lin, Y.; Anrather, J.; E., Csizmadia; Takigami, K.; Sato, K.; Grey, S. T; Colvin, A.M.; Choi, A. M. K; K.D., Poss; Bach, F. H. 1998. "Expression of heme-oxygenase-1 (HO-1) can determinate the cardiac xenograft survival.", Nature Medicine 4, 4: 1073 - 1077.

33.	Soares, Miguel C. P; Bach, F. H; Anrather, J.. 1998. "Overexpression of a transdominant negative mutant of p65/RelA inhibits NF-B in endothelial cells without sensitizing to apoptosis", Journal of Immunology 161, 161: 4572 - 4582.

34.	Gianello, P.; Soares, Miguel C. P; Latinne, D.; Bazin, H.. 1998. "Xenotransplantation. ", Handbook of vertebrate immunology, 1998: 619 - 635.

35.	Siegel, J. B; Grey, S. T; Lesnikoski, B. A; Kopp, C. W; Soares, M. P; Esch, J. S. A; Bach, F. H; Robson, S. C. 1997. "Xenogeneic endothelial cells activate human prothrombin", Transplantation 64, 6: 888 - 896.

36.	Soares, Miguel C. P; Havaux, X.; Cormont, F.; Nisol, F.; T., Besse; Gianello, P.; Latinne, D.; Bazin, H.. 1997. "Use of anti-µ monoclonal antibodies in Xenotransplatation: A potential approach to overcome vascular rejection", Xenotransplantation, 29: 399 - 410.

37.	Brostjan, C.; Anrather, J.; Csizmadia, V.; Stroka, D. M; Soares, M. P; Bach, F. H; Winkler, H.. 1996. "Glucocorticoid-mediated repression of NF kappa B activity in endothelial cells does not involve induction of I kappa B alpha synthesis", Journal of Biological Chemistry 271, 32: 19612 - 19616.

38.	Havaux, X.B.; Hori, S.; Soares, M.P.; Gianello, P.; Bazin, H.; Latinne, D.. 1996. "Processing of IgM/anti-IgM immune complexes by the liver of rats treated with anti-IgM monoclonal antibodies", Transplantation Proceedings 28, 2: 574 - 574.

39.	Soares, M. P; Van Beneden, R; Havaux, X.; W.J., Van D. W; Bach, F. H; Latinne, D.; Bazin, H.. 1994. "Characterisation of xenoreactive natural antibodies secreting cells in rats.", Xenotransplatation, 1: 118 - 124.

40.	Latinne, D.; Soares, Miguel C. P; Havaux, X.; Cormont, F.; Lesnikoski, B. A; Bach, F. H; Bazin, H.. 1994. "Depletion of IgM xenoreactive natural antibodies by injection of anti-µ monoclonal antibodies", Immunological Reviews, 141: 174 - 204.

41.	Soares, M. P; Latinne, D.; Elsen, M.; Figueroa, J.; Bach, F. H; Bazin, H.. 1993. "IN-VIVO DEPLETION OF XENOREACTIVE NATURAL ANTIBODIES WITH AN ANTI-MU MONOCLONAL-ANTIBODY", Transplantation 56, 6: 1427 - 1433.

Artigos em revistas sem arbitragem científica Papers in periodics without scientific refereeing

1.	Figueiredo, Nuno; Chora, Angelo; Raquel, Helena; Pejanovic, Nadja; Pereira, Pedro; Hartleben, Björn; Neves-Costa, Ana; Moita, Catarina; Pedroso, Dora; Pinto, Andreia; Marques, Sofia; Faridi, Hafeez; Costa, Paulo; Gozzelino, Raffaella; Zhao, Jimmy L.; Soares, Miguel P.; Gama-Carvalho, Margarida; Martinez, Jennifer; Zhang, Qingshuo; Döring, Gerd; Grompe, Markus; Simas, J. Pedro; Huber, Tobias B.; Baltimore, David; Gupta, Vineet; Green, Douglas R.; Ferreira, João A.; Moita, Luis F.. 2013. "Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis", Immunity 39, 5: 874 - 884.

2.	Parada, Esther; Egea, Javier; Buendia, Izaskun; Negredo, Pilar; Cunha, Ana C; Cardoso, Silvia; Soares, Miguel P; López, Manuela G. 2013. " The Microglial a7-Acetylcholine Nicotinic Receptor Is a Key Element in Promoting Neuroprotection by Inducing Heme Oxygenase-1 via Nuclear Factor Erythroid-2-Related Factor 2 ", Antioxidants & Redox Signaling 19, 11: 1135 - 11.

3.	Silva-Gomes, S.; Appelberg, R.; Larsen, R.; Soares, M. P; Gomes, M. S. 2013. "Heme Catabolism by Heme Oxygenase-1 Confers Host Resistance to Mycobacterium Infection", Infection and Immunity 81, 7: 2536 - 25.

4.	Potor, László; Bányai, Emese; Becs, Gergely; Soares, Miguel P; Balla, György; Balla, József; Jeney, Viktória. 2013. "Atherogenesis May Involve the Prooxidant and Proinflammatory Effects of Ferryl Hemoglobin", Oxidative Medicine and Cellular Longevity 2013, 10: 1 - 13.

5.	Medzhitov, R.; Schneider, D. S; Soares, M. P. 2012. "Disease Tolerance as a Defense Strategy", Science 335, 6071: 936 - 941.

6.	Gozzelino, Raffaella; Andrade, Bruno Bezerril; Larsen, Rasmus; Luz, Nivea F.; Vanoaica, Liviu; Seixas, Elsa; Coutinho, Antonio; Cardoso, Sílvia; Rebelo, Sofia; Poli, Maura; Barral-Netto, Manoel; Darshan, Deepak; Kühn, Lukas C.; Soares, Miguel P.. 2012. "Metabolic Adaptation to Tissue Iron Overload Confers Tolerance to Malaria", Cell Host & Microbe 12, 5: 693 - 704.

7.	Pejanovic, Nadja; Hochrainer, Karin; Liu, Tao; Aerne, Birgit L; Soares, Miguel P; Anrather, Josef; Yang, Chuen-Mao. 2012. "Regulation of Nuclear Factor ¿B (NF-¿B) Transcriptional Activity via p65 Acetylation by the Chaperonin Containing TCP1 (CCT)", PLoS ONE 7, 7: e42020 - e4.

8.	Mourão-Sá, Diego; Robinson, Matthew J; Zelenay, Santiago; Sancho, David; Chakravarty, Probir; Larsen, Rasmus; Plantinga, Maud; Van Rooijen, N; Soares, Miguel P; Lambrecht, Bart; Reis e S. C. 2011. "CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses", European Journal of Immunology 41, 10: 3040 - 30.

9.	Zenclussen, Maria L; Casalis, Pablo A; El-Mousleh, Tarek; Rebelo, Sofia; Langwisch, Stefanie; Linzke, Nadja; Volk, Hans-Dieter; Fest, Stefan; Soares, Miguel P; Zenclussen, Ana C. 2011. "Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide", The Journal of Pathology 225, 2: 293 - 304.

10.	Ferreira, Ana; Marguti, Ivo; Bechmann, Ingo; Jeney, Viktória; Chora, Ângelo; Palha, Nuno R.; Rebelo, Sofia; Henri, Annie; Beuzard, Yves; Soares, Miguel P.. 2011. "Sickle Hemoglobin Confers Tolerance to Plasmodium Infection", Cell 145, 3: 398 - 409.

11.	Gozzelino, Raffaella; Jeney, Viktoria; Soares, Miguel P. 2010. "Mechanisms of Cell Protection by Heme Oxygenase-1", Annual Review of Pharmacology and Toxicology 50, 1: 323 - 354.

12.	Nagy, E.; Eaton, J. W; Jeney, V.; Soares, M. P; Varga, Z.; Galajda, Z.; Szentmiklosi, J.; Mehes, G.; Csonka, T.; Smith, A.; Vercellotti, G. M; Balla, G.; Balla, J.. 2010. "Red Cells, Hemoglobin, Heme, Iron, and Atherogenesis", Arteriosclerosis, Thrombosis, and Vascular Biology 30, 7: 1347 - 1353.

13.	Cheng, C.; Noorderloos, M.; van Deel, E. D; Tempel, D.; den Dekker, W; Wagtmans, K.; Duncker, D. J; Soares, M. P; Laman, J. D; Duckers, H. J. 2010. "Dendritic Cell Function in Transplantation Arteriosclerosis Is Regulated by Heme Oxygenase 1", Circulation Research 106, 10: 1656 - 1666.

14.	Larsen, R.; Gozzelino, R.; Jeney, V.; Tokaji, L.; Bozza, F. A; Japiassu, A. M; Bonaparte, D.; Cavalcante, M. M; Chora, A.; Ferreira, A.; Marguti, I.; Cardoso, S.; Sepulveda, N.; Smith, A.; Soares, M. P. 2010. "From the cover: A Central Role for Free Heme in the Pathogenesis of Severe Sepsis", Science Translational Medicine 2, 51: 5171 - 5171.

15.	Cheng, C.; Noordeloos, A. M; Jeney, V.; Soares, M. P; Moll, F.; Pasterkamp, G.; Serruys, P. W; Duckers, H. J. 2009. "Heme Oxygenase 1 Determines Atherosclerotic Lesion Progression Into a Vulnerable Plaque", Circulation 119, 23: 3017 - 3027.

16.	Seixas, E.; Gozzelino, R.; Chora, A.; Ferreira, A.; Silva, G.; Larsen, R.; Rebelo, S.; Penido, C.; Smith, N. R; Coutinho, A.; Soares, M. P. 2009. "From the cover: Heme oxygenase-1 affords protection against noncerebral forms of severe malaria", Proceedings of the National Academy of Sciences 106, 37: 15837 - 15842.

17.	Silva, G.; Jeney, V.; Chora, A.; Larsen, R.; Balla, J.; Soares, M. P. 2009. "Oxidized Hemoglobin Is an Endogenous Proinflammatory Agonist That Targets Vascular Endothelial Cells", Journal of Biological Chemistry 284, 43: 29582 - 29595.

18.	Soares, Miguel P; Bach, Fritz H. 2009. "Heme oxygenase-1: from biology to therapeutic potential", Trends in Molecular Medicine 15, 2: 50 - 58.

19.	Soares, Miguel P; Marguti, Ivo; Cunha, Andreia; Larsen, Rasmus. 2009. "Immunoregulatory effects of HO-1: how does it work?", Current Opinion in Pharmacology 9, 4: 482 - 489.

20.	Rodrigues, Lénia; Filipe, Josina; Seldon, Mark P; Fonseca, Lidia; Anrather, Josef; Soares, Miguel P; Simas, J P. 2009. "Termination of NF-¿B activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase", The EMBO Journal 28, 9: 1283 - 12.

21.	Seixas, E.; Gozzelino, R.; Chora, Â.; Ferreira, A.; Silva, G.; Larsen, R.; Rebelo, S.; Penido, C.; Smith, N.R.; Coutinho, A.; Soares, M.P.. 2009. "Heme oxygenase-1 affords protection against noncerebral forms of severe malaria", Proceedings of the National Academy of Sciences of the United States of America 106, 37: 15837 - 15.

22.	Ferreira, Ana; Balla, József; Jeney, Viktória; Balla, György; Soares, Miguel P. 2008. "A central role for free heme in the pathogenesis of severe malaria: the missing link?", Journal of Molecular Medicine 86, 10: 1097 - 1111.

23.	Kinderlerer, A. R; Pombo Gregoire, I; Hamdulay, S. S; Ali, F.; Steinberg, R.; Silva, G.; Ali, N.; Wang, B.; Haskard, D. O; Soares, M. P; Mason, J. C. 2008. "Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor: a role for increased bilirubin and ferritin", Blood 113, 7: 1598 - 1607.

24.	Ozaki, K.S.; Marques, G.M.; Nogueira, E.; Feitoza, R.Q.; Cenedeze, M.A.; Franco, M.F.; Mazzali, M.; Soares, M.P.; Pacheco-Silva, A.; Câmara, N.O.S.. 2008. "Improved renal function after kidney transplantation is associated with heme oxygenase-1 polymorphism", Clinical Transplantation 22, 5: 609 - 616.

25.	Epiphanio, Sabrina; Mikolajczak, Sebastian A; Gonçalves, Lígia A; Pamplona, Ana; Portugal, Silvia; Albuquerque, Sónia; Goldberg, Michael; Rebelo, Sofia; Anderson, Daniel G; Akinc, Akin; Vornlocher, Hans-Peter; Kappe, Stefan H; Soares, Miguel P; Mota, Maria M. 2008. "Heme Oxygenase-1 Is an Anti-Inflammatory Host Factor that Promotes Murine Plasmodium Liver Infection", Cell Host & Microbe 3, 5: 331 - 338.

26.	Pamplona, Ana; Ferreira, Ana; Balla, József; Jeney, Viktória; Balla, György; Epiphanio, Sabrina; Chora, Ângelo; Rodrigues, Cristina D; Gregoire, Isabel P; Cunha-Rodrigues, Margarida; Portugal, Silvia; Soares, Miguel P; Mota, Maria M. 2007. "Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria", Nature Medicine 13, 6: 703 - 710.

27.	Chora, Ângelo A; Fontoura, Paulo; Cunha, Andreia; Pais, Teresa F; Cardoso, Sílvia; Ho, Peggy P; Lee, Lowen Y; Sobel, Raymond A; Steinman, Lawrence; Soares, Miguel P. 2007. "Heme oxygenase–1 and carbon monoxide suppress autoimmune neuroinflammation", Journal of Clinical Investigation 117, 2: 438 - 447.

28.	Seldon, M.P.; Silva, G.; Pejanovic, N.; Larsen, R.; Gregoire, I.P.; Filipe, J.; Anrather, J.; Soares, M.P.. 2007. "Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-¿B RelA phosphorylation at serine 276", Journal of Immunology 179, 11: 7840 - 78.

29.	Soares, M.P.; Bach, F.H.. 2007. "Heme Oxygenase-1 in organ transplantation", Frontiers in Bioscience 12, 13: 4932 - 49.

30.	Ali, F.; Hamdulay, S.S.; Kinderlerer, A.R.; Boyle, J.J.; Lidington, E.A.; Yamaguchi, T.; Soares, M.P.; Haskard, D.O.; Randi, A.M.; Mason, J.C.. 2007. "Statin-mediated cytoprotection of human vascular endothelial cells: A role for Kruppel-like factor 2-dependent induction of heme oxygenase-1", Journal of Thrombosis and Haemostasis 5, 12: 2537 - 25.

31.	Zelenay, S.; Chora, A. A; Soares, M. P; Demengeot, J.. 2006. "Heme oxygenase-1 is not required for mouse regulatory T cell development and function", International Immunology 19, 1: 11 - 18.

32.	Silva, G.; Cunha, A.; Grégoire, I.P.; Seldon, M.P.; Soares, M.P.. 2006. "The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38a MAPK isoform", Journal of Immunology 177, 3: 1894 - 19.

33.	Yamashita, K.; Öllinger, R.; McDaid, J.; Sakahama, H.; Wang, H.; Tyagi, S.; Csizmadia, E.; Smith, N.R.; Soares, M.P.; Bach, F.H.. 2006. "Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs", FASEB Journal 20, 6: 776 - 778.

34.	Pombo Gregoire, I; Correia, A.M.; Soares, M.P.. 2006. "Tu-P7:62 Heme oxygenase-1 derived carbon monoxide inhibits atherosclerosis", Atherosclerosis Supplements 7, 3: 198 - 198.

35.	Öllinger, R.; Bilban, M.; Erat, A.; Froio, A.; McDaid, J.; Tyagi, S.; Csizmadia, E.; Graça-Souza, A.V.; Liloia, A.; Soares, M.P.; Otterbein, L.E.; Usheva, A.; Yamashita, K.; Bach, F.H.. 2005. "A natural inhibitor of vascular smooth muscle cell proliferation", Circulation 112, 7: 1030 - 10.

36.	Camara, N.O.S.; Soares, M.P.. 2005. "Heme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunction", Free Radical Biology and Medicine 38, 4: 426 - 435.

37.	Wagener, F. A. D. T. G. 2003. "Different Faces of the Heme-Heme Oxygenase System in Inflammation", Pharmacological Reviews 55, 3: 551 - 571.

38.	Otterbein, Leo E; Soares, Miguel P; Yamashita, Kenichiro; Bach, Fritz H. 2003. "Heme oxygenase-1: unleashing the protective properties of heme", Trends in Immunology 24, 8: 449 - 455.

39.	Sass, G. 2003. "Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice", Hepatology 38, 4: 909 - 918.

40.	Berberat, P.O.; Katori, M.; Kaczmarek, E.; Anselmo, D.; Lassman, C.; Ke, B.; Shen, X.; Busuttil, R.W.; Yamashita, K.; Csizmadia, E.; Tyagi, S.; Otterbein, L.E.; Brouard, S.; Tobiasch, E.; Bach, F.H.; Kupiec-Weglinski, J.W.; Soares, M.P.. 2003. "Heavy chain ferritin acts as an antiapoptotic gene that protects livers from ischemia reperfusion injury.", The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17, 12: 1724 - 17.

41.	Brouard, S.; Berberat, P.O.; Tobiasch, E.; Seldon, M.P.; Bach, F.H.; Soares, M.P.. 2002. "Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-¿B to protect endothelial cells from tumor necrosis factor-a-mediated apoptosis", Journal of Biological Chemistry 277, 20: 17950 - 17.

42.	Günther, L.; Berberat, P.O.; Haga, M.; Brouard, S.; Neal Smith, R; Soares, M.P.; Bach, F.H.; Tobiasch, E.. 2002. "Carbon monoxide protects pancreatic ß-cells from apoptosis and improves islet function/survival after transplantation", Diabetes 51, 4: 994 - 999.

43.	Soares, Miguel P; Usheva, Anny; Brouard, Sophie; Berberat, Pascal O; Gunther, Lukas; Tobiasch, Edda; Bach, Fritz H. 2002. "Modulation of Endothelial Cell Apoptosis by Heme Oxygenase-1-Derived Carbon Monoxide", Antioxidants & Redox Signaling 4, 2: 321 - 329.

44.	Soares, Miguel C. P. 2001. "Modulation of Vascular Inflammation", Helix. Amgen Magazine of Biotechnology 10, 2: 14 - 21.

45.	Wang, N.; Lee, J.M.; Soares, M.P.; Csizmadia, E.; Xu, D.; Liew, F.Y.; Smith, N. R; Bach, F.H.; Lin, Y.. 2001. "TH2 cytokines regulate gene expression and proinflammatory responses in xenografts", Transplantation Proceedings 33, 1-2: 776 - 777.

46.	Wang, N.; Lee, J.M.; Soares, M.P.; Csizmadia, E.; Robson, S.C.; Smith, N. R; Bach, F.H.; Lin, Y.. 2001. "Long-term survival of hamster hearts in presensitized rats", Transplantation Proceedings 33, 1-2: 747 - 748.

47.	Soares, M.P.; Brouard, S.; Smith, R.N.; Otterbein, L. E; Choi, A.M.; Bach, F.H.. 2000. "Expression of heme oxygenase-1 by endothelial cells: A protective response to injury in transplantation", Expert Opinion on Therapeutic Targets 4, 1: 11 - 27.

48.	Otterbein, L.E.; Bach, F.H.; Alam, J.; Soares, M. P; Lu, H.T.; Wysk, M.; Davis, R.J.; Flavell, R.A.; Choi, A.M.K.. 2000. "Carbon monoxide has anti-inflammatory effects involving the mitogen- activated protein kinase pathway", Nature Medicine 6, 4: 422 - 428.

49.	Dehoux, J.-P.; Hori, S.; Talpe, S.; Bazin, H.; Latinne, D.; Soares, M.P.; Gianello, P.. 2000. "Specific depletion of preformed IgM natural antibodies by administration of anti-µ monoclonal antibody suppresses hyperacute rejection of pig to baboon renal xenografts", Transplantation 70, 6: 935 - 946.

50.	Soares, Miguel C. P; Lin, Y.; Sato, K.; Bach, F. H; Csizmadia, E.. 1999. "Xenograft accommodation: Survival of xenografts in the presence of anti-graft antibodies and complement that precipitate rejection of naive xenografts", Journal of Immunology, 163: 2850 - 2857.

51.	Bach, F.H.; Soares, M. P; Lin, Y.; Ferran, C.. 1999. "Barriers to xenotransplantation", Transplantation Proceedings 31, 4: 1819 - 18.

52.	Sato, Koichiro; Takigami, Ko; Miyatake, Tsukasa; Latinne, Dominique; Bazin, Herv??; Bach, Fritz H; Soares, Miguel C. P. 1999. "Delayed Xenograft Rejection is Initiated by Elicited IgM Anti-Graft Antibodies.", Transplantation 67, 7: S135 - S1.

53.	Sato, Koichiro; Lin, Yuan; Smith, R. N; Czismadia, Eva; Takigami, Ko; Choi, Augustine M; Bach, Fritz H; Soares, Miguel C. P. 1999. "Early Inhibition of heme oxygenase enzymatic activity precipitates xenograft rejection.", Transplantation 67, 7: S135 - S1.

54.	Lin, Y.; Soares, M.P.; Sato, K.; Takigami, K.; Csizmadia, E.; Smith, N. R; Bach, F.H.. 1999. "Accommodated xenografts survive in the presence of anti-donor antibodies and complement that precipitate rejection of naive xenografts", Journal of Immunology 163, 5: 2850 - 28.

55.	Lin, Yuan; Soares, Miguel C. P; Sato, Koichiro; Tokigami, Ko; Csizmadia, Eve; Anrather, Josef; Bach, Fritz H. 1999. "Th2 cells/cytokines promote the long-term survival of hamster hearts in rats.", Transplantation 67, 7: S135 - S1.

56.	Lin, Y.; Soares, M.P.; Sato, K.; Takigami, K.; Csizmadia, E.; Anrather, J.; Bach, F.H.. 1999. "Rejection of hamster cardiac xenografts by rat CD4+ or CD8+ T cells", Transplantation Proceedings 31, 1-2: 959 - 960.

57.	Lin, Y.; Soares, M.P.; Sato, K.; Takigami, K.; Csizmadia, E.; Anrather, J.; Bach, F.H.. 1999. "Rejection of cardiac xenografts by CD4+ or CD8+ T cells", Journal of Immunology 162, 2: 1206 - 12.

58.	Ferran, C.; Stroka, D.M.; Badrichani, A.Z.; Cooper, J.T.; Wrighton, C.J.; Soares, M. P; Grey, S.T.; Bach, F.H.. 1998. "A20 inhibits NF-¿B activation in endothelial cells without sensitizing to tumor necrosis factor-mediated apoptosis", Blood 91, 7: 2249 - 22.

59.	Soares, M.P.; Muniappan, A.; Kaczmarek, E.; Koziak, K.; Wrighton, C.J.; Steinhäuslin, F.; Ferran, C.; Winkler, H.; Bach, F.H.; Anrather, J.. 1998. "Adenovirus-mediated expression of a dominant negative mutant of p65/RelA inhibits proinflammatory gene expression in endothelial cells without sensitizing to apoptosis", Journal of Immunology 161, 9: 4572 - 45.

60.	Soares, M. P; Havaux, X.; Van Beneden, R; Kinet, I.; Chentoufi, A.A.; Nisol, F.; Cormont, F.; Bazin, H.; Latinne, D.. 1998. "Differential inhibition of B-cell development and xenoreactive natural antibody production by administration of anti-µ or anti-d monoclonal antibodies in adult rats", Transplantation 66, 3: 357 - 364.

61.	Miyatake, T.; Koyamada, N.; Hancock, W.W.; Soares, M.P.; Bach, F.H.. 1998. "Survival of accommodated cardiac xenografts upon retransplantation into cyclosporine-treated recipients", Transplantation 65, 12: 1563 - 15.

62.	Soares, M.P.; Lin, Y.; Anrather, J.; Csizmadia, E.; Takigami, K.; Sato, K.; Grey, S.T.; Colvin, R.B.; Choi, A.M.; Poss, K.D.; Bach, F.H.. 1998. "Expression of heme oxygenase-1 can determine cardiac xenograft survival", Nature Medicine 4, 9: 1073 - 10.

63.	Soares, Miguel C. P; Bach, F. H; Anrather, J.; Ferran, C.; C.J., Wrighton; H., Winkler; W.W., Hancock. 1997. "Modification of vascular responses in xenotranplantation inflammation and apoptosis", Nature Medicine 3, 9: 944 - 948.

64.	Hancock, W.W.; Miyatake, T.; Koyamada, N.; Kut, J.P.; Soares, M. P; Russell, M.E.; Bach, F.H.; Sayegh, M.H.. 1997. "Effects of leflunomide and deoxyspergualin in the guinea pig¿rat cardiac model of delayed xenograft rejection: Suppression of B cell and C-C chemokine responses but not induction of macrophage lectin", Transplantation 64, 5: 696 - 704.

65.	Anrather, J.; Csizmadia, V.; Brostjan, C.; Soares, M.P.; Bach, F.H.; Winkler, H.. 1997. "Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-¿B", Journal of Clinical Investigation 99, 4: 763 - 772.

66.	Soares, M. P; Havaux, X.; Nisol, F.; Bazin, H.; Latinne, D.. 1996. "Modulation of rat B cell differentiation in vivo by the administration of an anti-µ monoclonal antibody", Journal of Immunology 156, 1: 108 - 118.

67.	Lesnikoski, B.A.; Shaffer, D.A.; Van der W. W; Dalmasso, A.P.; Soares, M.P.; Latinne, D.; Bazin, H.; Hancock, W.W.; Bach, F.H.. 1995. "Endothelial and host mononuclear cell activation and cytokine expression during rejection of pig-to-baboon discordant xenografts", Transplantation Proceedings 27, 1: 290 - 291.

68.	Soares, M. P; Havaux, X.; Van Beneden, R; Van der W. W; Bach, F.H.; Bazin, H.; Latinne, D.. 1995. "Characterisation of rat anti-guinea pig circulating xenoreactive natural antibodies and secreting cells", Transplantation Proceedings 27, 1: 282 - 285.

69.	Latinne, D.; Denis, O.; Soares, M. P; Bazin, H.. 1994. "Achievement of serum immunoglobulin depletion in rodents by injections of anti-immunoglobulin antibodies", Transplantation Proceedings 26, 2: 1006 - 10.

70.	Soares, M. P; Nisol, F.; Bach, F.H.; Bazin, H.; Latinne, D.. 1994. "Use of anti-µ monoclonal antibody as a therapeutic approach to achieve depletion of xenoreactive natural antibodies", Transplantation Proceedings 26, 3: 1357 - 13.

71.	Reding, R.; Soares, M. P; Baranski, A.; Nisol, F.; Tomasi, J.-P.; Jamart, J.; Barker, A.; Latinne, D.; Lambotte, L.; Bazin, H.. 1994. "Preformed antibody and complement rebound after plasma exchange: Analysis of immunoglobulin isotypes and effect of splenectomy", Transplant Immunology 2, 3: 231 - 237.

72.	Van der W. W; Blakely, M.L.; Hancock, W. W; Soares, M. P; Latinne, D.; Bazin, H.; Bach, F.H.. 1994. "Sustained suppression of xenoreactive natural antibodies: Anti-IgM monoclonal antibody and anti-B cell immunosuppressants", Transplantation Proceedings 26, 3: 1372 - 13.

73.	Soares, M.P.; Lu, X. S; Havaux, X.; Baranski, A.; Reding, R.; Latinne, D.; Daha, M.; Lambotte, L.; Bach, F.H.; Bazin, H.. 1994. "In vivo IgM depletion by anti-µ monoclonal antibody therapy: The role of IgM in hyperacute vascular rejection of discordant xenografts", Transplantation 57, 7: 1003 - 10.

74.	Elsen, M.; Soares, M. P; Latinne, D.; Cornet, A.; Bazin, H.. 1993. "Role of activated natural killer and CD4+, CD8+ cells in the cellular rejection of a discordant xenograft", Transplantation Proceedings 25, 1: 447 - 449.

75.	Soares, M.P.; Latinne, D.; Elsen, M.; Figueroa, J.; Bach, F.H.; Bazin, H.. 1993. "In vivo depletion of xenoreactive natural antibodies with an anti-µ monoclonal antibody", Transplantation 56, 6: 1427 - 14.

76.	Soares, M. P; Latinne, D.; Elsen, M.; Kinard, F.; Reding, R.; Lambotte, L.; Otte, J.B.; Bazin, H.. 1992. "Isotype characterization of rat preformed natural antibodies against guinea pig cells", Transplantation Proceedings 24, 2: 451 - 452.

77.	Chavez, Viviana; Soares, Miguel P; Bazin, Hervé. 1992. "CD23 Expression in Aged Rats", International Archives of Allergy and Immunology 97, 4: 330 - 336.

Orientações Orientations

Participação no júri de Graus Académicos Academic Degrees jury participation

Participação em Comissões de Avaliação Evaluation comissions participation

Participação em eventos Event participation

Orientações Orientations

Tese de Doutoramento Phd Thesis

Concluídas Completed

1.	Ângelo António Ferreira Chaves do Rosário Chora , Role of the protective gene Heme Oxygenase-1 in the control of T cell mediated responses, 2008. Tese (Doutoramento em Ciência Biomédicas) - Universidade de Lisboa, Bolseiro(a) de Fundação para a Ciência e a Tecnologia (Orientador).

2.

Mark Turan Jan Pena Seldon , Molecular mechanisms underlying the protective effects of Heme Oxygenase-1: interaction with NF-¿B Signal transduction pathway in endothelial cells, 2006. Tese (Doutoramento em Ciência Biomédicas) - Universidade do Porto, Bolseiro(a) de Fundação para a Ciência e a Tecnologia (Orientador).

Dissertação de Mestrado Master degree dissertation

Concluídas Completed

1.	Nuno Miguel Ribeiro Palha , Heme Oxygenase-1 underlies the “protective trait” afforded by sickle cell disease against severe acute malaria, 2008. Dissertação (Mestrado em Biologia Humana e Ambiente) - Universidade de Lisboa (Orientador).

2.	Eliane Cristina Monteiro Cortez , Regulation of T cell responses by Heme Oxygenase-1, 2008. Dissertação (Mestrado em Biologia Molecular e Genética ) - Universidade de Lisboa (Orientador).

Monografia de conclusão de curso de aperfeiçoamento/especialização Specialization course conclusion monograph

Concluídas Completed

1.	Matteo Villa , Heme, a double edged sword linking sickle cell disease and cerebral malaria, 2009. Monografia (Aperfeiçoamento/Especialização em Corso di laurea specialista in biotecnologie mediche) - Universita Degli Studi di Milano (Orientador).

Trabalho de conclusão de curso de Bacharelato/Licenciatura Bachelor/Licenciate degree conclusion work

Concluídas Completed

1.	Cláudia Alexandra Ribeiro de Almeida , Modulation of NF-kB dependent pro-inflammatory genes in endothelial cells by the stress responsive enzyme Heme Oxygenase-1, 2005. Trabalho de Conclusão de Curso (Licenciatura em Biologia Microbiana e Genética ) - Universidade de Lisboa (Orientador).

2.	Ana Mónica Pais Correia , Atheroprotective effect of Inhaled Carbon Monoxide, 2005. Trabalho de Conclusão de Curso (Licenciatura em Biologia Microbiana e Genética ) - Universidade de Lisboa (Orientador).

3.	Josina Côrte-Real Filipe , Modulation of Nuclear Factor kB by Murine gamma-Herpesvirus 68, 2005. Trabalho de Conclusão de Curso (Licenciatura em Bioquímica) - Universidade de Lisboa (Orientador).

4.	Andreia Cristina Marques da Cunha , Involvement of p38 MAPK signal transduction pathway in the biological effects of Heme Oxygenase-1, 2004. Trabalho de Conclusão de Curso (Licenciatura em Biologia Microbiana e Genética ) - Universidade de Lisboa (Orientador).

Participação no júri de Graus Académicos Academic Degrees jury participation

Doutoramento Phd

1.	Soares, Miguel Che Parreira. Participação no júri de Maria do Rosário Sambo . Genetic risk factors for the cerebral malaria syndrome in Angolan children, 2010. Tese (Doutoramento em Ciência Biomédicas) - Universidade de Lisboa.

2.	Soares, Miguel Che Parreira. Participação no júri de Virginia Oliveira Marques. Modulation of NF-kB-dependent gene expression by H2O2: a major role for a simple chemical process in a complex biological response, 2009. Tese (Doutoramento em Ciência Biomédicas) - Universidade de Lisboa.

3.	Soares, Miguel Che Parreira. Participação no júri de Marco Busnelli. Pathogenic role of hypercholesterolemia in a pre-clinical model of vascular injury in pigs, 2008. Tese (Program in Translational and Molecular Medicine) - University of Milano-Bicocca School of Medicine and Faculty of Science.

4.

Soares, Miguel Che Parreira. Participação no júri de Allessandra Scagliarini. Nitric oxide modulates proliferative and apoptotic responses of vascular smooth muscle cells differentially dependent on heme oxygenase-1 activity, 2008. Tese (Program in Translational and Molecular Medicine) - University of Milano-Bicocca School of Medicine and Faculty of Science.

5.	Soares, Miguel Che Parreira. Participação no júri de Raffaella Gozzelino. Implication of TNF death receptors and antagonists in the neuronal apoptotic death, 2007. Tese (Doutoramento em Ciències Mèdiques Bàsiques ) - Universitat de Lleida Hospital Universitari Arnau de Vilanova.

6.	Soares, Miguel Che Parreira. Participação no júri de Vasco Andre Machado de Oliveira. Insights into TRIP and NOD2 signaling, 2006. Tese (Doutoramento em Ciência Biomédicas) - Universidade do Porto.

7.	Soares, Miguel Che Parreira. Participação no júri de Filipe Almeida Monteiro. Insights on signal transduction pathways involved in familial amyloidic polyneuropathy neurodegeneration, 2006. Tese (Doutoramento em Ciência Biomédicas) - Universidade do Porto.

8.	Soares, Miguel Che Parreira. Participação no júri de Juliette Fitau. Contribution de TIMP-1 et de la molécule adaptatrice Lnk aux mécanismes de survie et d’activation de la cellule endothéliale, 2005. Tese (Doutoramento) - Universite de Nantes.

9.	Soares, Miguel Che Parreira. Participação no júri de Delphine Bouchet. . Manipulation du systèm immunitaire par transfert de gènes dans des modèles de transplantation d’organes vascularisés, 2002. Tese (Doutoramento) - Universite de Nantes.

Participação em Comissões de Avaliação Evaluation comissions participation

1.	Agence d´évaluation de la recherche et de l´enseignement superieur - Valérie Quesniaux, 2010, Institut National de la Sante et de la Recherche Medicale.

Participação em eventos Event participation

Participação como Membro da Comissão Científica Participation as Member of the Program Committee

1.	Workshop on Tolerance versus resistance to infection, 2010 (Workshop). Nome do evento: Workshop on Tolerance versus resistance to infection; Nome da Instituição: Instituto Gulbenkian de Ciência; Cidade do evento: Arrabida / Portugal.

2.	4th European Workshop on Immune mediated inflammatory diseases, 2009 (Workshop). Nome do evento: 4th European Workshop on Immune mediated inflammatory diseases; Cidade do evento: Cascais / Portugal.

3.	Recent Advances in Pattern Recognition | Toll2008, 2008 (Congresso). Nome do evento: Recent Advances in Pattern Recognition | Toll2008; Cidade do evento: Cascais / Portugal.

4.

2nd European Society of Hematology “Club du globule rouge et du fer”- Euroconference on disorders of iron homeostasis, erythrocytes and erythropoiesis, 2006 (Conferência). Nome do evento: Euroconference on disorders of iron homeostasis, erythrocytes and erythropoiesis; Nome da Instituição: European Society of Hematology - “Club du globule rouge et du fer”; Cidade do evento: Cascais / Portugal .

Produção científica Scientific production

Dados complementares data

Total

Produção científica Scientific production

125

Livros e capítulos Books and book chapters

7

Capítulos de livros publicados Published book chapters

7

Artigos científicos em revistas Papers in periodics

118

Com arbitragem científica With scientific refereeing

41

Sem arbitragem científica Without scientific refereeing

77

Total

Dados complementares (Additional data)

23

Orientações Orientations

9

Participação no Júri de Graus Académicos Academic Degrees jury participation

9

Participação em Comissões de Avaliação Evaluation comissions participation

1

Participação em Eventos Event participation

4

	Ana Margarida Grenho Ferreira
	Ângelo António Ferreira Chaves do Rosário Chora
	Ivo Marguti