José Miguel Gomes Moreira Pêgo. Concluiu Ciências da Saúde - Ciências Biológicas e Biomédicas pela Universidade do Minho em 2008. É Professor Auxiliar na Universidade do Minho. Publicou 20 artigos em revistas especializadas e 4 trabalhos em actas de eventos, possui 2 capítulos de livros publicados. Possui 3 itens de produção técnica. Participou em 3 eventos em Portugal. Orientou 3 trabalhos de conclusão de curso de bach./licenciatura na área de Línguas e Literaturas. Recebeu 2 prémios e/ou homenagens. Entre 2003 e 2005 participou em 1 projecto de investigação. Actualmente participa em 3 projectos de investigação. Actua nas áreas de Ciências Médicas com ênfase em Medicina Básica e Ciências Naturais com ênfase em Ciências Biológicas. Nas suas actividades profissionais interagiu com 86 colaboradores em co-autorias de trabalhos científicos. No seu curriculum DeGóis os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: stress, rat, anxiety, amygdala, bed nucleus of the stria terminalis, Anestesiologia, NOTES, swine, animals e Natural Orifices Transluminal Endoscopic Surgery.
Endereço de acesso a este CV: http://www.degois.pt/visualizador/curriculum.jsp?key=5461253130804358

Nome completo Full name	José Miguel Gomes Moreira Pêgo
Nome em citações bibliográficas Quoting name	Pêgo, José Miguel
Categoria profissional Position	Professor Auxiliar
Domínio científico de atuação Scientific domain	Ciências Médicas-Medicina Básica. Ciências Naturais-Ciências Biológicas.

Endereço profissional Professional address

Universidade do Minho Escola de Ciências da Saúde Instituto de Investigação em Ciências da Vida e Saúde Escola de Ciências da Saúde - Universidade do Minho - Campus de Gualtar Gualtar 4710-057 Braga Portugal Telefone: (+351)253604930Extensão: 604930 Fax: (+351)253604809 Correio electrónico: jmpego@ecsaude.uminho.pt Homepage: www.ecsaude.uminho.pt

Sexo Gender

Masculino»Male

2004-2008	Doutoramento Phd
Ciências da Saúde - Ciências Biológicas e Biomédicas. Universidade do Minho, Portugal.

1995-2001	Licenciatura Licentiate degree
Medicina (6 anos » years) . Universidade do Porto, Portugal.

2009-2009	Especialização/ Pós-Graduação Specialization/ Postgraduation
Laboratory Animal Science. Universidade do Minho, Portugal.

2004-2008	Especialização Médica Medical specialization
Hospital de São Marcos, Portugal.

Universidade do Minho

Jan/2009-Actual

Professor Auxiliar

Hospital São José de Fafe

Out/2008-Actual

Assistente

Universidade do Minho

Set/2011-Actual

Professor Auxiliar

Jan/2009-Ago/2011

Professor Auxiliar

Jul/2008-Dez/2008

Professor Auxiliar

Out/2001-Jun/2004

Outra Situação

Hospital de São Marcos

Mar/2008-Out/2008

Assistente

Jan/2001-Dez/2003

Interno Geral

Universidade do Minho

Jan/2009-Actual	Instituto de Investigação em Ciências da Vida e Saúde,Escola de Ciências da Saúde
Linhas de investigação»Research fields: Neurosciences

Universidade do Minho

Jan/2009-Actual	Instituto de Investigação em Ciências da Vida e Saúde,Escola de Ciências da Saúde

Universidade do Minho

Jan/2009-Actual

Curso»Academic program: Medicina

Universidade do Minho

Jan/2009-Actual

Curso»Academic program: Medicina Disciplinas lecionadas»Taught units: Biopatologia(Docente)

Jul/2008-Dez/2008

Curso»Academic program: Medicina Disciplinas lecionadas»Taught units: Biopatologia(Docente)

Jul/2004-Jun/2008

Curso»Academic program: Medicina Disciplinas lecionadas»Taught units: Sistemas Orgânicos e Funcionais(Docente) Biopatologia(Docente)

Out/2001-Mai/2004

Curso»Academic program: Medicina Disciplinas lecionadas»Taught units: Sistemas Orgânicos e Funcionais(Monitor)

Hospital de São Marcos

Jan/2001-Dez/2003

Estágios realizados»Traineeships:    - Cirurgia Geral (3 meses)    - Pediatria (3 meses)    - Medicina Interna (6 meses)    - Ginecologia e Obstetrícia (3 meses)    - Medicina Comunitária e Familiar (3 meses)    - Imagiologia (6 meses)

Hospital São José de Fafe

Out/2008-Actual

Hospital de São Marcos

Mar/2008-Out/2008
Serviço realizado»Executed service: Anestesiologia

Jan/2004-Fev/2008	Escola de Ciências da Saúde
Serviço realizado»Executed service: Anestesiologia

Participação como Investigador Participation as Researcher

2007- Novas perspectivas neurobiológicas da depressão: para além da “hipótese neuroquímica” -New perspectives in the neurobiology of depression: beyond the “neurochemical hypothesis”

Referência do projeto»Project reference: PTDC/SAU-NEU/72699/2006.

2010-2013 Análise multimodal da neurobiologia da depressão-Multimodal analysis of the neurobiology of depression

Referência do projeto»Project reference: PTDC/SAU-NEU/105180/2008.

2011-2012 Projecto Estratégico - LA 26 - 2011-2012-Strategic Project - LA 26 - 2011-2012

Referência do projeto»Project reference: PEst-C/SAU/LA0026/2011.

2003-2005 Cognitive modulation of pain: interaction between the limbic system and the supraspinal pain control system-Cognitive modulation of pain: interaction between the limbic system and the supraspinal pain control system

Referência do projeto»Project reference: Projecto FCT nº 46399.

Outro Tipo de Participação Other kind of participation

2010-2012 Neudesina - estudo da função de um novo factor neurotrófico-Neudesin - characterization of a novel neurotrophic factor

Referência do projeto»Project reference: PTDC/SAU-OSM/104475/2008.

Compreende Understandig	Português (Bem), Inglês (Bem), Espanhol (Bem), Francês (Bem).
Fala Speaking	Português (Bem), Inglês (Bem), Espanhol (Bem), Francês (Pouco).
Lê Reading	Português (Bem), Inglês (Bem), Espanhol (Bem), Francês (Bem).
Escreve Writing	Português (Bem), Inglês (Bem), Espanhol (Pouco), Francês (Pouco).

2003	Prémio Grünenthal Dor, Fundação Grünenthal .
2007	Prémio Grünenthal Dor, Fundação Grünenthal .

Abr/2012 - Actual	Simulation in Healthcare, Membro.
Mar/2012 - Actual	Society in Europe for Simulation Applied to Medicine, Membro.
Out/2011 - Actual	Sociedade Portuguesa de Simulação Aplicada às Ciências da Saúde, Membro fundador.
Fev/2011 - Actual	European Board of Medical Assessors, Membro.
Set/2010 - Actual	European Society of Anesthesiologists, Membro.
Mar/2008 - Actual	Society for Neuroscience, Membro.
Mar/2008 - Actual	Committee for European Education in Anaesthesiology (Portugal), Membro. Member of the Scientific Council.

Capítulos de livros publicados Published book chapters

1.	Pêgo, José M; Sousa, Nuno; Sousa, João C; Almeida, Osborne F. X. 2010. Stress and the Neuroendocrinology of Anxiety Disorders.  In Behavioral Neurobiology of Anxiety and Its Treatment, ed. Stein, Murray B.; Steckler, Thomas, 97 - 120. ISBN: 978-3-642-02911-. Berlin Heidelber: Springer-Verlag.

2.	Pêgo, José M; Sousa, Nuno; Almeida, Osborne F. X. 2005. The cellular biology of the stress response.  In Handbook of Stress and the Brain , ed. T. Steckler, N.H. Kalin & J.M.H.M. Reul, 10000 - 10001. ISBN: 978-0-444-51822-4. Amsterdam: Elsevier Science Title. Description The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry. Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation and emotionality. Part 2 treats the complexity of short-term and long-term regulation of stress responsivity, the role of stress in psychiatric disorders as based on both preclinical and clinical evidence, and the current status with regard to new therapeutic strategies targetting stress-related disorders. .

Artigos em revistas com arbitragem científica Papers in periodics with scientific refereeing

1.	Batalha, V L; Pego, J M; Fontinha, B M; Costenla, A R; Valadas, J S; Baqi, Y; Radjainia, H; Müller, C E; Sebastião, A M; Lopes, L V. 2012. "Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation", Molecular Psychiatry, x: 0 - 0.

2.	Ventura-Silva, Ana P; Pêgo, José M; Sousa, João C; Marques, Ana R; Rodrigues, Ana J; Marques, Fernanda; Cerqueira, João J; Almeida, Osborne F. X; Sousa, Nuno. 2012. "Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode", European Journal of Neuroscience 36, 10: 3396 - 3406. The bed nucleus of the stria terminalis (BNST) is critically implicated in anxiety behavior and control of the hypothalamus pituitary adrenal axis. Having previously shown that chronic stress triggers dendritic/synaptic remodeling in specific nuclei of the BNST, we characterised the pattern of activation of neurons within different regions of the BNST under basal conditions and after an anxiogenic stimulus in control and stressed rats. Under basal conditions, stressed, but not control, animals displayed increased cFOS expression in the dorsomedial nucleus and decreased activation of the principal nucleus. This pattern resembled that observed in controls that had been exposed to the anxiogenic stimulus. Subsequent analysis of various BNST subnuclei revealed differential patterns of gene expression in controls and stressed animals. We found decreased levels of corticotropin-releasing hormone 1 receptor mRNA expression in the dorsomedial and fusiform nuclei, and a global increase in the levels of corticotropin-releasing hormone 2 receptor in the principal nucleus. In addition, we found subnuclei-specific increases in GABAA and NR2B receptors in stressed animals, which suggest changes in the GABAergic and glutamergic innervation of the BNST. Importantly, these findings were associated with increased anxiety-like behavior and impaired control of the hypothalamus pituitary adrenal axis in stressed animals. In summary, these data reveal that chronic stress shifts the pattern of response of the BNST to an anxiogenic mode and provide new information on the underlying mechanisms of the stress-induced hypercorticalism and hyperanxious status.

3.	Pêgo, José M; Sousa, Nuno; Cerqueira, João J; Leão, Pedro; Oliveira, M.; Rodrigues, Ana J. 2011. "Programming Effects of Antenatal Corticosteroids Exposure in Male Sexual Behavior.", The Journal of Sexual Medicine, 10000: 10000 - 10001. Introduction. Brain regions implicated in sexual behavior begin to differentiate in the last trimester of gestation. Antenatal therapy with corticosteroids is often used in clinical practice during this period to accelerate lung maturation in preterm-risk pregnancies. Clinical and animal studies highlighted major behavioral impairments induced later in life by these treatments, especially when synthetic corticosteroids are used. Aim. To evaluate the implications of acute prenatal treatment with natural vs. synthetic corticosteroids on adult male rat sexual behavior and its neurochemical correlates. Methods. Twelve pregnant Wistar rats were injected with dexamethasone (DEX-1 mg/kg), corticosterone (CORT-25 mg/kg), or saline on late gestation (pregnancy days 18 and 19). Following this brief exposure to corticosteroids, we assessed the sexual behavior of the adult male progeny and subsequently associated these behaviors with the levels of catecholamines and mRNA of dopamine and androgen receptors (AR) in brain regions relevant for sexual behavior. Main Outcome Measures. Sexual behavior of adult male offspring was assessed by exposure to receptive females. This was associated with serum testosterone levels and levels of catecholamines (determined by high-performance liquid chromatography) and dopamine and AR mRNA expression (real-time polymerase chain reaction [PCR]) in brain regions implicated in sexual behavior. Results. Prenatal DEX exposure resulted in a decreased number and increased mounts and intromissions latencies in adulthood. These findings were associated with decreased levels of serum testosterone and increased hypothalamic expression of AR mRNA. DEX animals also displayed lower dopamine levels and higher dopamine receptor mRNA expression both in hypothalamus and nucleus accumbens (NAcc). The milder phenotype of CORT animals was associated only with decreased dopamine levels in NAcc. Conclusion. Antenatal corticotherapy programs adult male sexual beha.

4.	Oliveira, Mário; Rodrigues, Ana-João; Leão, Pedro; Cardona, Diana; Pêgo, José M; Sousa, Nuno. 2011. "The bed nucleus of stria terminalis and the amygdala as targets of antenatal glucocorticoids: implications for fear and anxiety responses", Psychopharmacology 220, 3: 443 - 453.

5.	Rodrigues, A J; Leão, P; Pêgo, J M; Cardona, D; Carvalho, M M; Oliveira, M; Costa, B M; Carvalho, A F; Morgado, P; Araújo, D; Palha, J A; Almeida, O F. X; Sousa, N. 2011. "Mechanisms of initiation and reversal of drug-seeking behavior induced by prenatal exposure to glucocorticoids", Molecular Psychiatry, x: 0 - 0.

6.	Bessa, João M; Mesquita, Ana R; Oliveira, Mário; Pêgo, José M; Cerqueira, João J; Palha, Joana A; Almeida, Osborne F. X; Sousa, Nuno. 2009. "A trans-dimensional approach to the behavioral aspects of depression", Frontiers in Behavioral Neuroscience 3, 1: 1 - 7.

7.	Rolanda, Carla; Lima, E.; Silva, D.; Moreira, I.; Pêgo, José M; Macedo, G.; Correia-Pinto, J.. 2009. "Invivo assessment of gastrotomy closure with over-the-scope clips in an experimental model for varicocelectomy (with video).", GastrointestEndosc 70, 6: 1137 - 1145. Abstract BACKGROUND: Gastrotomy closure remains the major limiting factor for human translation of transgastric surgery; the over-the-scope clip (OTSC) system was proposed as a possibility for this purpose. Transgastric access is good for a pelvic approach, making varicocelectomy a possible indication for natural orifice transluminal endoscopic surgery (NOTES). OBJECTIVE: To evaluate the reliability of the OTSC system in vivo after transgastric testicular vessel ligation (varicocelectomy model). DESIGN: There were 3 experimental groups (5 animals in each): groups 1 and 3, gastrotomy dilation up to 18 mm, surgery was performed with a double-channel endoscope; group 2, gastrotomy dilation up to 13 mm, surgery was performed with a single-channel endoscope. SETTING: Surgical Sciences Research Domain, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal. INTERVENTIONS: Bilateral testicular vessel ligation by transgastric access. Gastrotomy closed with the largest version of OTSC system (12 mm): a single clip in groups 1 and 2, and 2 clips in group 3. Animals were monitored for 2 weeks, killed, and submitted for necropsy. MAIN OUTCOME MEASUREMENTS: Adequacy of closure and healing after the use of the OTSC system. Statistical analysis. RESULTS: Vessel ligation was easily achieved in all groups. Although differences in the complication rate did not reach statistical significance (P = .099), there was a clear tendency for a better prognosis in groups 2 and 3 than group 1. In fact, only 2 animals from group 1 had complications related to incomplete gastrotomy closure. LIMITATIONS: Small number of animals per group; nonrandomized study. CONCLUSIONS: The OTSC system was shown to be easy and efficient for gastrotomy closure in a survival experimental model of varicocelectomy, when correctly matching the gastrotomy size with the clip size and/or number. IF = 6,713.

8.	Pêgo, José M; Sousa, Nuno; Leão, Pedro; Pinto-Ribeiro, Filipa; Almeida, Armando. 2009. "Antinociception induced by chronic glucocorticoid treatment is correlated to local modulation of spinal neurotransmitter content.", Molecular Pain, 5: 41 - 52. While acute effects of stress on pain are well described, those produced by chronic stress are still a matter of dispute. Previously we demonstrated that chronic unpredictable stress results in antinociception in the tail-flick test, an effect that is mediated by increased levels of corticosteroids. In the present study, we evaluated nociception in rats after chronic treatment with corticosterone (CORT) and dexamethasone (DEX) in order to discriminate the role of each type of corticosteroid receptors in antinociception. Results Both experimental groups exhibited a pronounced antinociceptive effect after three weeks of treatment when compared to controls (CONT); however, at four weeks the pain threshold in CORT-treated animals returned to basal levels whereas in DEX-treated rats antinociception was maintained. In order to assess if these differences are associated with altered expression of neuropeptides involved in nociceptive transmission we evaluated the density of substance P (SP), calcitonin gene-related peptide (CGRP), somatostatin (SS) and B2-¿-aminobutiric acid receptors (GABAB2) expression in the spinal dorsal horn using light density measurements and stereological techniques. After three weeks of treatment the expression of CGRP in the superficial dorsal horn was significantly decreased in both CORT and DEX groups, while GABAB2 was significantly increased; the levels of SP for both experimental groups remained unchanged at this point. At 4 weeks, CGRP and SP are reduced in DEX-treated animals and GABAB2 unchanged, but all changes were restored to CONT levels in CORT-treated animals. The expression of SS remained unaltered throughout the experimental period. Conclusion These data indicate that corticosteroids modulate nociception since chronic corticosteroid treatment alters the expression of neuropeptides involved in nociceptive transmission at the spinal cord level. As previously observed in some supraspinal areas, the exclusive GR ac IF = 4,187.

9.	Pêgo, José M; Salgado, António; Sousa, Nuno; Malva, João O; Sousa, R A; Fraga, Joana S; Silva, B A; Neves, N M; Reis, Rui L. 2009. "Effects of Starch/ Polycaprolactone-based Blends for Spinal Cord Injury Regeneration in Neurons/Glial Cells Viability and Proliferation ", Journal of Bioactive and Compatible Polymers 24, 3: 235 - 248.

10.	Gonçalves, Leonor; Silva, Rui; Pinto-Ribeiro, Filipa; Pêgo, José M; Bessa, João M; Pertovaara, Antti; Sousa, Nuno; Almeida, Armando. 2008. "Neuropathic pain is associated with depressive behaviour and induces neuroplasticity in the amygdala of the rat", Experimental Neurology 213, 1: 48 - 56. IF = 3,974.

11.	Lima, Estevão; Rolanda, Carla; Osório, Luís; Pêgo, José M; Silva, David; Henriques-Coelho, Tiago; Carvalho, José L; Bergström, Maria; Park, Per-Ola; Mosse, Charles A; Swain, Paul; Correia-Pinto, Jorge. 2008. "Endoscopic Closure of Transmural Bladder Wall Perforations", European Urology 178, 6: 2648 - 54. IF = 6,512.

12.	Pêgo, José M; Morgado, P; Pinto, L G; Cerqueira, João J; Almeida, Osborne F. X; Sousa, N. 2008. "Dissociation of the morphological correlates of stress-induced anxiety and fear", The European Journal of Neuroscience 27, 6: 1503 - 16. IF = 3,385.

13.	Lima, Estevão; Henriques-Coelho, Tiago; Rolanda, Carla; Pêgo, José M; Silva, David; Carvalho, José L; Correia-Pinto, Jorge. 2007. "Transvesical thoracoscopy: a natural orifice translumenal endoscopic approach for thoracic surgery", Surgical Endoscopy 21, 6: 854 - 8. IF = 2,242.

14.	Lima, Estevão; Rolanda, Carla; Pêgo, José M; Henriques-Coelho, Tiago; Silva, David; Osório, Luís; Moreira, Ivone; Carvalho, José L; Correia-Pinto, Jorge. 2007. "Third-generation nephrectomy by natural orifice transluminal endoscopic surgery", The Journal of Urology 178, 6: 2648 - 54. IF = 3,952.

15.	Mesquita, A R; Pêgo, José M; Summavielle, T; Maciel, P; Almeida, Osborne F. X; Sousa, N. 2007. "Neurodevelopment milestone abnormalities in rats exposed to stress in early life", Neuroscience 147, 4: 1022 - 33. IF = 3,352.

16.	Rolanda, Carla; Lima, Estevão; Pêgo, José M; Henriques-Coelho, Tiago; Silva, David; Moreira, Ivone; Macedo, Guilherme; Carvalho, José L; Correia-Pinto, Jorge. 2007. "Third-generation cholecystectomy by natural orifices: transgastric and transvesical combined approach (with video)", Gastrointestinal Endoscopy 65, 1: 111 - 7. IF = 5,888.

17.	Lima, Estevão; Rolanda, Carla; Pêgo, José M; Henriques-Coelho, Tiago; Silva, David; Carvalho, José L; Correia-Pinto, Jorge. 2006. "Transvesical endoscopic peritoneoscopy: a novel 5 mm port for intra-abdominal scarless surgery", The Journal of Urology 176, 2: 802 - 5. IF = 3,956 .

18.	Oliveira, Mário; Bessa, João M; Mesquita, Ana R; Tavares, Hugo; Carvalho, André; Silva, Rui; Pêgo, José M; Cerqueira, João J; Palha, Joana A; Almeida, Osborne F. X; Sousa, Nuno. 2006. "Induction of a hyperanxious state by antenatal dexamethasone: a case for less detrimental natural corticosteroids", Biological Psychiatry 59, 9: 844 - 52. IF = 7,154.

19.	Pêgo, José M; Morgado, P; Cerqueira, João J; Almeida, Osborne F. X; Sousa, N. 2006. "Mismatch between anxiety status and morphometric parameters in the amygdala and bed nucleus of the stria terminalis", Behavioural Brain Research 173, 2: 320 - 5. IF = 2,591.

20.	Cerqueira, João J; Pêgo, José M; Taipa, Ricardo; Bessa, João M; Almeida, Osborne F. X; Sousa, Nuno. 2005. "Morphological correlates of corticosteroid-induced changes in prefrontal cortex-dependent behaviors", The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 25, 34: 7792 - 800. IF = 7,506.

21.	Pinto-Ribeiro, F; Almeida, Armando; Pêgo, José M; Cerqueira, João J; Sousa, Nuno. 2004. "Chronic unpredictable stress inhibits nociception in male rats", Neuroscience Letters 359, 1-2: 73 - 76. IF = 2,019.

Trabalhos completos/resumidos em eventos com arbitragem científica Papers in conference proceedings with scientific refereeing

1.	Pêgo, José M; Salgado, António; Carvalho, Miguel M; Campos, Filipa; Bessa, João M; Cerqueira, João J; Sousa, Nuno; Baltazar, G. 2011. "A Behavioral Characterization on the Motor and Emotional Deficits of the 6-OHDA Parkinson Disease Rat Model", Trabalho apresentado em 12th Meeting of the Portuguese Society for Neurosciences, In 12th Meeting of the Portuguese Society for Neurosciences, Lisboa. Parkinson’s disease (PD) is a neurodegenerative condition affecting the dopaminergic system, causing the emergence of both motor and non-motor complications. The development of animal models mimicking this condition brought new insights regarding the neuropathologic mechanisms of this disease, and endowed us with suitable tools to develop new therapeutical strategies. One of the most widely used models is the unilaterally 6-OHDA-lesioned rat model, characterized by a biased rotatory behavior after apomorphine/methamphetamine challenge. However, little is known about other behavioral features of this model, particularly at the emotional/cognitive level. Importantly, this model has been extensively used to assess the therapeutical relevance of novel treatments, particularly at the motor level. The improvement of the behavioral characterization of this model could reveal additional features besides the motor deficits, which could in the future be useful to address treatment-related improvements in a multidimensional fashion. Therefore, the objective of the present work was to pursue a more thorough behavioral characterization of this model, particularly at the emotional and cognitive levels. We believe that our findings can be highly relevant for the validity of this model in PD regenerative medicine. Wistar-Han rats were unilaterally injected with 6-OHDA or saline in the medial forebrain bundle (coordinates related to bregma, AP= -4,4mm; ML= -1,0mm; DV= -7,8mm). Behavioral assessment was done using: rotorod, elevated plus maze (EPM), acoustic startle (AS), Morris water maze (MWM), open field (OF), forced swimming test (FST), sucrose preference test (SPT) and rotameter (apomorphine-derived rotatory behavior assessment). Tyrosine hydroxylase immunohistochemistry was performed to assess the effectiveness of the lesion. Lesioned animals displaying apomorphine induced rotatory behavior had severe dopaminergic degeneration. In this group of animals, it was poss.

2.	Pêgo, José M; Sousa, Nuno; Almeida, Osborne F. X; Cerqueira, João J; Morgado, P. 2007. "Chronic Stress Associated Anxiety Correlates With Morphological Changes in Bed Nucleus of Stria Terminalis But Not Amygdala", Trabalho apresentado em 10th Meeting of the Portuguese Society for Neurosciences, In 10th Meeting of the Portuguese Society for Neurosciences, Ofir.

3.	Pêgo, José M; Sousa, Nuno; Cerqueira, João J; Almeida, Osborne F. X; Morgado, P.. 2007. "Chronic Stress Induced Anxiety-like Behavior Does Not Correlate with Structural Changes in Pyramidal Neurons of Basolateral Amygdala", Trabalho apresentado em 10th Meeting of the Portuguese Society for Neurosciences, In 10th Meeting of the Portuguese Society for Neurosciences, Ofir.

4.	Pêgo, José M; Almeida, Osborne F. X; Sousa, Nuno; Mesquita, Ana R; Summavielle, Teresa. 2007. "Neurodevelopment Milestone Abnormalities in rats Exposed to Stress in Early Life", Trabalho apresentado em 10th Meeting of the Portuguese Society for Neurosciences, In 10th Meeting of the Portuguese Society for Neurosciences, Ofir.

Curso de curta duração lecionado Taught short course

1.

Pêgo, José M. InAnestesia - Introdução à Anestesiologia Clínica, 2011 (Aperfeiçoamento), promovido por Escola de Ciências da Saúde. Duração: 5 dias. Local: Universidade do Minho, Cidade: Braga, Tipo de participação: Organizador. A Anestesiologia é uma área científica da Medicina pouco representada na maioria dos curricula das escolas médicas e, por isso, de pouca familiaridade no final da Formação Pré-graduada e Internato do Ano Comum. Com o intuito de colmatar esta ausência e permitir uma transição menos abrupta foi idealizado um curso de iniciação à Anestesiologia Clínica – InAnestesia. O curso foi dirigido aos internos do primeiro ano de especialidade, durante a primeira semana de trabalho e pretendeu criar um ambiente de introdução à prática da Anestesiologia. Os aspectos formativos do curso, englobaram fundamentos teóricos, básicos à prática da Anestesiologia, apresentados sob a forma de sessões teóricas, e fundamentos práticos com recurso a simuladores, onde os internos puderam aprender e treinar gestos clínicos da prática diária dos anestesiologistas que, na globalidade, consideramos essenciais para os primeiros passos na especialidade.

2.	Pêgo, José M. Fisiologia Cardiovascular, 2010 (Aperfeiçoamento), promovido por Committee for European Education in Anaesthesiology (Portugal),. Duração: 25 dias., Tipo de participação: Docente.

Organização de evento Event organization

1.	Pêgo, José M. Congresso da Sociedade Portuguesa de Neurociências,2009 (Congresso / Organização).

Curso de curta duração Short duration course

1.

Pêgo, José M. InAnestesia - Introdução à Anestesiologia Clínica,2011 (Especialização). A Anestesiologia é uma área científica da Medicina pouco representada na maioria dos curricula das escolas médicas e, por isso, de pouca familiaridade no final da Formação Pré-graduada e Internato do Ano Comum. Com o intuito de colmatar esta ausência e permitir uma transição menos abrupta foi idealizado um curso de iniciação à Anestesiologia Clínica – InAnestesia. O curso foi dirigido aos internos do primeiro ano de especialidade, durante a primeira semana de trabalho e pretendeu criar um ambiente de introdução à prática da Anestesiologia. Os aspectos formativos do curso, englobaram fundamentos teóricos, básicos à prática da Anestesiologia, apresentados sob a forma de sessões teóricas, e fundamentos práticos com recurso a simuladores, onde os internos puderam aprender e treinar gestos clínicos da prática diária dos anestesiologistas que, na globalidade, consideramos essenciais para os primeiros passos na especialidade.

Orientações Orientations

Participação no júri de Graus Académicos Academic Degrees jury participation

Participação em eventos Event participation

Orientações Orientations

Tese de Doutoramento Phd Thesis

Em curso Ongoing

1.

António Manuel Melo Soares de Almeida, General anesthetics effects in cognitive modulation, 2010. Tese (Medicina) - Universidade do Porto, Bolseiro(a) de Fundação Calouste Gulbenkian (Co-orientador). Billions of patients worldwide have already been anaesthesized. Each year 200 millions of patients are anesthetized. The aim of anaesthesia is to achieve the conditions to perform a diagnostic or therapeutic intervention in the patient without inducing physiological and psychological stress. There exist Clinical evidences of postoperative cognitive change. In vivo studies also shown cognitive and molecular changes induced by GA exposure. The aim of this project is to determine the effects of GA in cognitive flexibility. Studies suggest changes both in long term cellular protein expression, and impairment in striatal dopaminergic after GA exposure. For the purpose we will expose rodents to GA to try to assess changes in cognition processes related to cortico-basal ganglia network.

2.	Ana Paula Ventura da Silva, Molecular and functional correlates of stress-related anxiety, 2009. Tese (Ciências da Saúde - Ciências Biológicas e Biomédicas) - Universidade do Minho, Bolseiro(a) de Universidade do Minho (Orientador).

Dissertação de Mestrado Master degree dissertation

Em curso Ongoing

1.

Ana Rita Fernandes Marques, In vivo studies of changes induced by chronic stress in the physiological proprieties of neurons involved in the brain circuitries underlying anxiety, 2010. Dissertação (Neurociências) - Universidade do Minho, Bolseiro(a) de Fundação para a Ciência e a Tecnologia (Orientador). Anxiety disorders affect a large portion of the world population and are frequently long-lasting and debilitating. Chronic stress plays an important role in their etiology. Several studies have shown that animals exposed to chronic unpredictable stress (CUS) present anxiety-like behavior correlated with hypothalamic–pituitary–adrenal (HPA) axis dysfunction and structural changes in the brain, principally in limbic structures. The mechanisms by which chronic stress alters central circuits that mediate anxiety-like emotional behavior are still largely unknown. Substantial evidence has implicated the bed nucleus of the stria terminalis (BST) in the regulation of the HPA axis, acting as a relay nucleus between limbic structures and the hypothalamic paraventricular nucleus (PVN). This is enhanced by previous results showing a hypertrophy of dendrites and spine sprouting in the BST anterodivision after CUS exposure. Nevertheless it is not known if the stress-induced structural and behavioral changes are associated with an altered pattern of activation in the BST. To address this question, electrophysiological studies will be conducted in stressed and control animals. A CUS paradigm will be used to induce anxiety-like behavior in rats, which will be evaluated in three different tests: open field, elevated plus maze and acoustic startle. Electrophysiological proprieties of single cell units in dorsomedial/fusiform and principal BST subnuclei of both stressed and control animals will be recorded in basal conditions. Afterwards BST spontaneous and sonorous-evoked activity will be recorded immediately after manipulation of central nucleus amygdala, in order to see the role of amygdala inputs over BST. .

Trabalho de conclusão de curso de Bacharelato/Licenciatura Bachelor/Licenciate degree conclusion work

Concluídas Completed

1.	Dânia Marlene de Sousa Moreira, Tradução Especializada na Área da Medicina com base no Dicionário Pschyrembel Klinisches Woerterbuch, 2009. Trabalho de Conclusão de Curso (Licenciatura em Licenciatura em Línguas Estrangeiras Aplicadas) - Universidade do Minho (Co-orientador).

2.	Sofia Maria da Costa Mesquita Guimarães, Tradução Especializada na Área da Medicina: Doenças Neurológicas, 2009. Trabalho de Conclusão de Curso (Licenciatura em Licenciatura em Línguas Estrangeiras Aplicadas) - Universidade do Minho.

3.	Marlene Oliveira da Silva, Tradução Especializada na Área da Medicina com base no Dicionário Pschyrembel Klinisches Woerterbuch, 2009. Trabalho de Conclusão de Curso (Licenciatura em Licenciatura em Línguas Estrangeiras Aplicadas) - Universidade do Minho (Orientador).

Participação no júri de Graus Académicos Academic Degrees jury participation

Doutoramento Phd

1.

José Miguel Pêgo; José Henrique Dias Pinto de Barros; Jorge Manuel Mergulhão de Castro Tavares; Pedro Augusto de Melo Lopes Ferreira; Carla Maria de Moura Lopes; Ana Azevedo Cardoso de Oliveira. Participação no júri de Fernando José Pereira Alves Abelha. Outcome in surgical cricital care patients, 2010. Tese (Medicina) - Universidade do Porto.

2.

José Miguel Pêgo; Leão, Cecília; Isaura Tavares; Armando Almeida; Antti Pertovaara; Andrew Rice. Participação no júri de Maria Leonor Barbosa Gonçalves. Plasticity of the pain control system induced by neuropathic pain: the amygdala-medulla system, 2009. Tese (Ciências da Saúde - Ciências Biológicas e Biomédicas) - Universidade do Minho.

3.

José Miguel Pêgo; Nuno Sousa; Leão, Cecília; Tavares, Amélia; Leonard, Brian. Participação no júri de Ana Raquel Marcelino Mesquita. An integrative biological assessment of the programming effects of glucocorticoids upon the developing brain: Insights on their relevance for future psychiatric pathologies, 2008. Tese (Ciências da Saúde - Ciências Biológicas e Biomédicas) - Universidade do Minho.

Mestrado Master degree

1.

Pêgo, José Miguel; Jorge Manuel Mergulhão de Castro Tavares; Joaquim Viana. Participação no júri de Sofia Gabriela Afonso Afonso Reis Serra. Avaliação do Consumo de desflurano nos doentes com monitorização da profundidade anestésica através do índice biespectral: estudo comparativo com a monitorização baseada em parâmetros clínicos., 2009.  Dissertação (Anestesiologia e Terapêutica da Dor) - Universidade de Coimbra.

2.

Pêgo, José Miguel; Maria Filomena Trabucho Caeiro; Rui Artur Manuel dos Santos Malhó; Maria Tuna Oliveira Brites. Participação no júri de Eduarda Cristina Duarte Magalhães Coutinho. Neuronal Cytoskeletal Dynamic Modification Induced by Unconjugated Bilirubin, 2009.  Dissertação (Biologia Molecular e Humana) - Universidade de Lisboa.

Bacharelato/Licenciatura Degree of licentiate

1.

José Miguel Pêgo; Mário Matos; Cláudia Breitbarth. Participação no júri de Marlene Oliveira da Silva. Tradução Especializada nas Ciências da Saúde com base no dicionário Pschyrembel Klinisches Woerterbuch, 2009. Trabalho de Conclusão de Curso (Bacharelato/Licenciatura em Licenciatura em Línguas Estrangeiras Aplicadas) - Universidade do Minho.

2.

José Miguel Pêgo; Cláudia Breitbarth; Mário Matos. Participação no júri de Dânia Marlene de Sousa Moreira. Tradução Especializada nas Ciências da Saúde com base no dicionário Pschyrembel Klinisches Woerterbuch, 2009. Trabalho de Conclusão de Curso (Bacharelato/Licenciatura em Licenciatura em Línguas Estrangeiras Aplicadas) - Universidade do Minho.

3.

José Miguel Pêgo; Cláudia Breitbarth; Mário Matos. Participação no júri de Sofia Maria da Costa Mesquita Guimarães. Tradução Especializada nas Ciências da Saúde: doenças neurológicas, 2009. Trabalho de Conclusão de Curso (Bacharelato/Licenciatura em Licenciatura em Línguas Estrangeiras Aplicadas) - Universidade do Minho.

Participação em eventos Event participation

Participação como Membro da Comissão Científica Participation as Member of the Program Committee

1.	II Jornadas Ciência e Medicina, 2011 (Encontro). Nome do evento: II Jornadas Ciência e Medicina - Neurociências; Nome da Instituição: NEMUM; Cidade do evento: Braga / Escola de Ciências da Saúde - Universidade do Minho.

Outro tipo de participação Other kind of participation

1.	Métodos de Controlo da Dor, 2011 (Workshop). Nome do evento: Minho Medical Meeting - Perinatal; Nome da Instituição: Núcleo de Estudantes de Medicina da Universidade do Minho; Cidade do evento: Braga / Escola de Ciências da Saúde.

2.	Simulação Avançada em Anestesiologia , 2010 (Workshop). Nome do evento: Simulação Avançada em Anestesiologia ; Nome da Instituição: Escola de Ciências da Saúde; Cidade do evento: Braga / Universidade do Minho.

Produção científica Scientific production

Produção técnica Technical production

Produção artística/cultural Artistical/cultural production

Dados complementares data

Total

Produção científica Scientific production

27

Livros e capítulos Books and book chapters

2

Capítulos de livros publicados Published book chapters

2

Artigos científicos em revistas Papers in periodics

21

Com arbitragem científica With scientific refereeing

21

Trabalhos em eventos Papers in conference proceedings

4

Com arbitragem científica With scientific refereeing

4

Total

Produção técnica Technical production

3

Outros tipos de produção técnica Other technical production

3

Total

Produção artística/cultural Artistical/cultural production

1

Total

Dados complementares (Additional data)

17

Orientações Orientations

6

Participação no Júri de Graus Académicos Academic Degrees jury participation

8

Participação em Eventos Event participation

3

	Fernanda Cristina Gomes de Sousa Marques
	João José Fernandes Cardoso de Araújo Cerqueira
	Jorge Manuel Nunes Correia Pinto
	Pedro Ricardo Luís Morgado
	Tiago Alexandre Henriques Coelho