Alexandra Gabriel Fraga. É Investigador Auxiliar na Universidade do Minho. Publicou 18 artigos em revistas especializadas. Possui 29 itens de produção técnica. Recebeu 4 prémios e/ou homenagens. Actua na área de Medicina Básica Nas suas actividades profissionais interagiu com 94 colaboradores em co-autorias de trabalhos científicos.
Endereço de acesso a este CV: http://curriculum.degois.pt/visualizador/curriculum.jsp?key=7916926247614835

Nome completo Full name	Alexandra Gabriel Fraga
Nome em citações bibliográficas Quoting name	Fraga, Alexandra Gabriel
Categoria profissional Position	Investigador Auxiliar
Domínio científico de atuação Scientific domain	Ciências Médicas-Medicina Básica. Ciências Naturais-Ciências Biológicas.

Endereço profissional Professional address

Universidade do Minho Escola de Ciências da Saúde Instituto de Investigação em Ciências da Vida e da Saúde (ICVS) Campus de Gualtar Gualtar 4710-057 Braga Portugal Telefone: (+351)253604834 Correio electrónico: afraga@ecsaude.uminho.pt

Sexo Gender

Feminino»Female

2006-2010	Doutoramento Phd
Ciências da Saúde. Universidade do Minho, Portugal.

1999-2003	Licenciatura Licentiate degree
Biologia Aplicada (4 anos » years) . Universidade do Minho, Portugal.

2011	Pós-Doutoramento Postdoctorate
Universidade do Minho, Portugal.

Universidade do Minho

Mar/2003-Actual

Investigador Auxiliar

Participação como Investigador Participation as Researcher

2010-2013 BURULIVAC- Identificação e desenvolvimento de vacinas candidatas para a Úlcera do Buruli-BuruliVac-Identification and development of vaccine candidates for Buruli Ulcer disease

Referência do projeto»Project reference: 241500. Seventh Framework Project

2006-2009 Role of Interleukin-23 (IL-23) and IL-17 in the regulation of the immune response to the infection by Mycobacterium tuberculosis

Referência do projeto»Project reference: PTDC/SAU-MII/70895/2006. FCT

2006-2009 Úlcera do Buruli - Da compreensão dos mecanismos de resistência do hospedeiro ao desenvolvimento de novas intervenções contra uma micobacteriose emergente- Buruli Ulcer – understanding of the mechanisms of host resistance and development of new interventions against an emergent mycobacteriosis

Referência do projeto»Project reference: Fundação Calouste Gulbenkian.

2003-2005 Impacto em saúde pública de micobacterioses de difícil tratamento: tuberculose multi-resistente e úlcera do Buruli-Impact of difficult-to-treat mycobacterioses in public health: multi-drug resistant Tuberculosis and Buruli ulcer

Referência do projeto»Project reference: Fundação Calouste Gulbenkian.

Compreende Understandig	Português (Bem), Inglês (Bem).
Fala Speaking	Português (Bem), Inglês (Bem).
Lê Reading	Português (Bem), Inglês (Bem).
Escreve Writing	Português (Bem), Inglês (Bem).

2006	Best Poster at II Simpósio Nacional de Citocinas, Citomed.
2006	Prémio de Excelência em Imunologia Arala Chaves, Sociedade Portuguesa de Imunologia.
2010	SPI Best Papr Award 2010, Sociedade Portuguesa de Imunologia.
2010	Prémio Pulido Valente Ciência 2010, Fundação Francisco Pulido Valente.

Actual

Sociedade Portuguesa de Imunologia, Membro.

Artigos em revistas com arbitragem científica Papers in periodics with scientific refereeing

1.	Trigo, Gabriela; Martins, Teresa G; Fraga, Alexandra G; Longatto-Filho, Adhemar; Castro, António G; Azeredo, Joana; Pedrosa, Jorge. 2013. "Phage Therapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad Model", PLoS Neglected Tropical Diseases 7, 4: e2183 - e2183.

2.	Martins, Teresa G; Gama, José B; Fraga, Alexandra G; Saraiva, Margarida; Silva, Manuel T; Castro, António G; Pedrosa, Jorge. 2012. "Local and Regional Re-Establishment of Cellular Immunity during Curative Antibiotherapy of Murine Mycobacterium ulcerans Infection", PLoS ONE 7, 2: 32740 - 32740.

3.	Fraga, Alexandra G; Martins, Teresa G; Torrado, Egídio; Huygen, Kris; Portaels, Françoise; Silva, Manuel T; Castro, António G; Pedrosa, Jorge. 2012. "Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer following BCG or Mycolactone-Negative Mycobacterium ulcerans Vaccination", PLoS ONE 7, 3: 33406 - 33406.

4.	Martins, Teresa G; Trigo, Gabriela; Fraga, Alexandra G; Gama, José B; Longatto-Filho, Adhemar; Saraiva, Margarida; Silva, Manuel T; Castro, António G; Pedrosa, Jorge. 2012. "Corticosteroid-Induced Immunosuppression Ultimately Does Not Compromise the Efficacy of Antibiotherapy in Murine Mycobacterium ulcerans Infection", PLoS Neglected Tropical Diseases 6, 11: e1925 - e1925.

5.	Fraga, A. G; Cruz, A.; Martins, T. G; Torrado, E.; Saraiva, M.; Pereira, D. R; Meyers, W. M; Portaels, F.; Silva, M. T; Castro, A. G; Pedrosa, J.. 2011. "Mycobacterium ulcerans triggers T cell immunity followed by local and regional but not systemic immunosuppression", Infection and Immunity 79, 1: 421 - 430.

6.	Torrado, E. *; Fraga, A. G. *; Logarinho, E.; Martins, T. G; Carmona, J. A; Gama, J. B; Carvalho, M. A; Proenca, F.; Castro, A. G; Pedrosa, J.. 2010. "IFN-gamma-dependent activation of macrophages during experimental infections by Mycobacterium ulcerans is impaired by the toxin mycolactone.", J Immunol 184, 2: 947 - 955. * E. Torrado and A. G. Fraga share co-authorship.

7.	Cruz, A.; Fraga, A. G; Fountain, J. J; Rangel-Moreno, J.; Torrado, E.; Saraiva, M.; Pereira, D. R; Randall, T. D; Pedrosa, J.; Cooper, A. M; Castro, A. G. 2010. "Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis.", J Exp Med 207, 8: 1609 - 1616.

8.	Kibadi, K.; Boelaert, M.; Fraga, A. G; Kayinua, M.; Longatto-Filho, A.; Minuku, J. B; Mputu-Yamba, J. B; Muyembe-Tamfum, J. J; Pedrosa, J.; Roux, J. J; Meyers, W. M; Portaels, F.. 2010. "Response to treatment in a prospective cohort of patients with large ulcerated lesions suspected to be Buruli Ulcer (Mycobacterium ulcerans disease).", PLoS Negl Trop Dis 4, 7: 7361 - 8.

9.	Eddyani, M.; Fraga, A. G; Schmitt, F.; Uwizeye, C.; Fissette, K.; Johnson, C.; Aguiar, J.; Sopoh, G.; Barogui, Y.; Meyers, W. M; Pedrosa, J.; Portaels, F.. 2009. "Fine-needle aspiration, an efficient sampling technique for bacteriological diagnosis of nonulcerative Buruli ulcer.", J Clin Microbiol 47, 6: 1700 - 1704.

10.	Kibadi, K.; Panda, M.; Tamfum, J. J; Fraga, A. G; Longatto Filho, A; Anyo, G.; Pedrosa, J.; Nakazawa, Y.; Suykerbuyk, P.; Meyers, W. M; Portaels, F.. 2008. "New foci of Buruli ulcer, Angola and Democratic Republic of Congo.", Emerg Infect Dis 14, 11: 1790 - 1792.

11.	Gaspar, M. M; Cruz, A.; Fraga, A. G; Castro, A. G; Cruz, M. E; Pedrosa, J.. 2008. "Developments on drug delivery systems for the treatment of mycobacterial infections.", Curr Top Med Chem 8, 7: 579 - 591.

12.	Gaspar, M. M; Cruz, A.; Penha, A. F; Reymao, J.; Sousa, A. C; Eleuterio, C. V; Domingues, S. A; Fraga, A. G; Filho, A. L; Cruz, M. E; Pedrosa, J.. 2008. "Rifabutin encapsulated in liposomes exhibits increased therapeutic activity in a model of disseminated tuberculosis.", Int J Antimicrob Agents 31, 1: 37 - 45.

13.	Portaels, F.; Meyers, W. M; Ablordey, A.; Castro, A. G; Chemlal, K.; de Rijk, P; Elsen, P.; Fissette, K.; Fraga, A. G; Lee, R.; Mahrous, E.; Small, P. L; Stragier, P.; Torrado, E.; Van Aerde, A; Silva, M. T; Pedrosa, J.. 2008. "First cultivation and characterization of Mycobacterium ulcerans from the environment.", PLoS Negl Trop Dis 2, 3: 178 - 178.

14.	Torrado, E.; Adusumilli, S.; Fraga, A. G; Small, P. L; Castro, A. G; Pedrosa, J.. 2007. "Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection.", Infect Immun 75, 8: 3979 - 3988.

15.	Torrado, E.; Fraga, A. G; Castro, A. G; Stragier, P.; Meyers, W. M; Portaels, F.; Silva, M. T; Pedrosa, J.. 2007. "Evidence for an intramacrophage growth phase of Mycobacterium ulcerans.", Infect Immun 75, 2: 977 - 987.

16.	Cruz, A.; Khader, S. A; Torrado, E.; Fraga, A. G; Pearl, J. E; Pedrosa, J.; Cooper, A. M; Castro, A. G. 2006. "Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection.", J Immunol 177, 3: 1416 - 1420.

17.	Oliveira, M. S; Fraga, A. G; Torrado, E.; Castro, A. G; Pereira, J. P; Filho, A. L; Milanezi, F.; Schmitt, F. C; Meyers, W. M; Portaels, F.; Silva, M. T; Pedrosa, J.. 2005. "Infection with Mycobacterium ulcerans induces persistent inflammatory responses in mice.", Infect Immun 73, 10: 6299 - 6310. * M. S. Oliveira and A. G. Fraga share co-authorship.

Artigos em revistas sem arbitragem científica Papers in periodics without scientific refereeing

1.	Gama, José B; Ohlmeier, Steffen; Martins, Teresa G; Fraga, Alexandra G; Sampaio-Marques, Belém; Carvalho, Maria A; Proença, Fernanda; Silva, Manuel T; Pedrosa, Jorge; Ludovico, Paula. 2014. "Proteomic Analysis of the Action of the Mycobacterium ulcerans Toxin Mycolactone: Targeting Host Cells Cytoskeleton and Collagen", PLoS Neglected Tropical Diseases 8, 8: e3066 - e3066.

Apresentação oral de trabalho Oral work presentation

1.	Fraga, Alexandra G. Genetic determinants of susceptibility - Buruli ulcer and invasive fungi cases,Fundamentals in Immunology and Infection,Braga,2014 (Seminário).

2.	Fraga, Alexandra G. Animal model of resistance to experimental Buruli ulcer: characterization of Mycobacterium ulcerans infection in the guinea-pig,Fundamentals in Immunology and Infection,Braga,2013 (Seminário).

3.	Fraga, Alexandra G. Experimental Buruli ulcer- understanding host-pathogen interactions,Fundamentals in Immunology and Infection,Braga,2012 (Seminário).

4.	Fraga, Alexandra G. Mouse model of Buruli Ulcer: protection conferred by Mycobacterium bovis BCG or with a mycolactone negative strain of M. ulcerans,WHO Annual Meeting on Buruli Ulcer,Geneva,2011 (Conferência ou palestra).

5.	Fraga, Alexandra G. Experimental Buruli ulcer: Insight on immunological responses during vaccination and treatment in the mouse model,Buruli Ulcer Symposium,Antwerp,2011 (Comunicação).

6.

Fraga, Alexandra G; Cruz, A.; Martins, T. G; Torrado, E.; Saraiva, M.; Pereira, D. R; Meyers, W. M; Portaels, F.; Silva, M. T; Castro, A. G; Pedrosa, J.. The role of adaptive immunity in Mycobacterium ulcerans infection ,Sociedade Portuguesa de Imunologia - International School of Immunology,Tavira,2010 (Comunicação).

7.

Fraga, A. G; Braga, J. E; Cruz, A.; Martins, T. G; Ramos-Pereira, D.; Meyers, W. M; Portaels, F.; Castro, A. G; Pedrosa, J.. Failure of the host to generate a protective response against infection with mycolactone-producing Mycobacterium ulcerans is not associated with an impaired development of a Tcell-mediated response in the draining lymph node.,European Society of Mycobacteriology ,Porto,2009 (Congresso).

8.

Torrado, E.; Fraga, A. G; Logarinho, E.; Carmona, J. A; Gama, J. B; Carvalho, M. A; Proenca, F.; Castro, A. G; Pedrosa, J.. The protective IFN-gamma-dependent activation of macrophages induced during infection with Mycobacterium ulcerans is impaired by the exotoxin mycolactone,Microbiotec,Vila Moura,2009 (Congresso).

9.	Fraga, A. G; Torrado, E.; Campos, S. A; Castro, A. G; Pedrosa, J.. Infection with virulent Mycobacterium ulcerans compromises the development of an immune response in the draining lymph nodes ,Congresso da Sociedade Portuguesa de Microscopia,Coimbra,2007 (Congresso).

Outra produção técnica Other technical production

1.	Fraga, Alexandra G. Susceptibility to Buruli Ulcer: multiple immune-genetic polymorphism dissection through a Benin (Africa) population case-control study,2013.

2.	Fraga, Alexandra G. Animal model of resistance to experimental Buruli ulcer: characterization of Mycobacterium ulcerans infection in the guinea-pig,2012.

3.	Fraga, Alexandra G; Martins, T. G; Torrado, E.; Portaels, F.; Silva, M. T; Castro, A. G; Pedrosa, J.. Cellular immunity confers transient protection in experimental Buruli ulcer following BCG or mycolactone-negative Mycobacterium ulcerans vaccination ,2011.

4.	Fraga, Alexandra G; Cruz, A.; Martins, T. G; Torrado, E.; Saraiva, M.; Pereira, D. R; Meyers, W. M; Portaels, F.; Silva, M. T; Castro, A. G; Pedrosa, J.. The role of adaptive immunity in Mycobacterium ulcerans infection ,2010.

5.	Torrado, E.; Fraga, A. G; Logarinho, E.; Martins, T. G; Carmona, J. A; Gama, J. B; Carvalho, M. A; Proenca, F.; Castro, A. G; Pedrosa, J.. Mycolactone interferes with the protective IFN-gamma-dependent activation of macrophages during infection with Mycobacterium ulcerans ,2009.

6.	Fraga, A. G; Braga, J. E; Cruz, A.; Martins, T. G; Pereira, D. R; Portaels, F.; Castro, A. G; Pedrosa, J.. Failure to generate a protective response against M. ulcerans is not associated with an impaired development of specific T cells in the draining lymph node. ,2009.

7.	Cruz, A.; Fraga, A. G; Pereira, D. R; Saraiva, A. L; Saraiva, M.; Correia-Neves, M.; Cooper, A. M; Pedrosa, J.; Castro, A. G. Control of Mycobacterium tuberculosis infection depends on the time of previous exposure to BCG vaccination,2009.

8.	Fraga, A. G; Torrado, E.; Braga, J. E; Castro, A. G; Pedrosa, J.. Mycobacterium ulcerans induces massive apoptosis in the draining lymph node of infected mice ,2008.

9.	Fraga, A. G; Torrado, E.; Campos, S. A; Castro, A. G; Pedrosa, J.. Lymph node dynamics during experimental infection by Mycobacterium ulcerans.,2007.

10.	Fraga, A. G; Torrado, E.; Castro, A. G; Pedrosa, J.. IFN-gamma induces LRG47 and nitric oxide in macrophages, playing a protective role following infection by a mycolactone-negative strain of Mycobacterium ulcerans,2006.

11.	Cruz, A.; Khader, S. A; Torrado, E.; Fraga, A. G; Pearl, J. E; Pedrosa, J.; Cooper, A. M; Castro, A. G. IL-17-producing CD4 T cells induced during mycobacterial infection are regulated by IFN-gamma,2006.

12.	Cruz, A.; Fraga, A. G; Torrado, E.; Cooper, A. M; Pedrosa, J.; Castro, A. G. Th17 cells inducing a massive recruitment of neutrophils may play a role in Koch´s reaction,2006.

13.	Fraga, A. G; Torrado, E.; Castro, A. G; Pedrosa, J.. IFN-gamma by inducing LRG-47 and Nitric Oxide plays a protective role following infection by low virulent strains of Mycobacterium ulcerans,2006.

14.	Torrado, E.; Fraga, A. G; Castro, A. G; Pedrosa, J.. TNF plays a protective role in infections by low virulent strains of Mycobacterium ulcerans,2006.

15.	Torrado, E.; Fraga, A. G; Castro, A. G; Silva, M. T; Pedrosa, J.. Intramacrophage growth of Mycobacterium ulcerans,2006.

16.	Torrado, E.; Fraga, A. G; Castro, A. G; Silva, M. T; Pedrosa, J.. Mycobacterium ulcerans growth within murine macrophages,2006.

17.	Torrado, E.; Fraga, A. G; Castro, A. G; Silva, M. T; Pedrosa, J.. TNF plays a protective role in infections by low virulent strains of Mycobacterium ulcerans,2006.

18.	Cruz, A.; Khader, S. A; Torrado, E.; Fraga, A. G; Pearl, J. E; Pedrosa, J.; Cooper, A. M; Castro, A. G. IFN-gamma limits the accumulation of CD4 , antigen specific, IL-17 producing T cells,2006.

19.	Oliveira, M. S; Fraga, A. G; Milanezi, F.; Schmitt, F. C; Portaels, F.; Silva, M. T; Castro, A. G; Pedrosa, J.. Study of the virulence of different Mycobacterium ulcerans strains in the footpad mouse model and characterization of the respective host inflammatory responses. ,2004.

20.	Oliveira, M. S; Fraga, A. G; Silva, M. T; Castro, A. G; Pedrosa, J.. Characterization of the virulence and pathology induced by different Mycobacterium ulcerans strains in the footpad mouse model.,2003.

Orientações Orientations

Orientações Orientations

Dissertação de Mestrado Master degree dissertation

Concluídas Completed

1.	Ana Rita de Araújo e Silva Gomes, The impact of immune gene polymorphisms in human Mycobacterium ulcerans infection, 2014. Dissertação (Ciências da Saúde) - Universidade do Minho (Orientador).

Trabalho de conclusão de curso de Bacharelato/Licenciatura Bachelor/Licenciate degree conclusion work

Concluídas Completed

1.	Ana Rita de Araújo e Silva Gomes, Úlcera de Buruli: Análise comparativa do modelo murino e do porquinho-da-índia durante a infeção por Mycobacterium ulcerans, 2012. Trabalho de Conclusão de Curso (Licenciatura em Bioquímica) - Universidade do Minho (Orientador).

Produção científica Scientific production

Produção técnica Technical production

Dados complementares data

Total

Produção científica Scientific production

18

Artigos científicos em revistas Papers in periodics

18

Com arbitragem científica With scientific refereeing

17

Sem arbitragem científica Without scientific refereeing

1

Total

Produção técnica Technical production

29

Outros tipos de produção técnica Other technical production

29

Total

Dados complementares (Additional data)

2

Orientações Orientations

2

	Andrea Patricia Ribeiro da Cruz
	António Gil Pereira de Castro
	Gabriela Alexandra Trigo Branquinho
	Jenny Andrea Carmona Valencia
	Jorge Manuel Rolo Pedrosa
	José Bernardo da Costa Gama
	Teresa Maria Gonçalves Martins

Jorge Manuel Rolo Pedrosa