Paulo António Rodrigues Pereira
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Data da última atualização
»Last update
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30/11/2016 |
Dados pessoais (Personal data)
Nome completo
Full name |
Paulo António Rodrigues Pereira |
Nome em citações bibliográficas
Quoting name |
Pereira, Paulo |
Endereço profissional
Professional address |
Instituto Português do Sangue e da Transplantação, I.P. Gabinete de Investigação, Inovação e Desenvolvimento Gabinete de Gestão da Qualidade Av. Miguel Bombarda 6 Lisboa 1000-208 Lisboa Portugal Telefone: (+351)210063047 Fax: (+351)210063070 Correio electrónico: paulo.pereira@ipst.min-saude.pt Homepage: http://www.ipst.pt |
Sexo
Gender |
Masculino»Male |
Graus Académicos
(Academic Degrees)
2015-2016 |
Doutoramento Phd |
Doutoramento em Biotecnologia, Especialidade de Microbiologia
(1 anos » years)
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Universidade Católica Portuguesa,
Portugal.
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2000-2005 |
Mestrado Master degree |
Engenharia da Saúde
(3 anos » years)
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Universidade Católica Portuguesa,
Portugal.
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Línguas (Languages)
Compreende Understandig |
Inglês (Bem). |
Fala Speaking |
Inglês (Bem). |
Lê Reading |
Inglês (Bem). |
Escreve Writing |
Inglês (Bem). |
Produção científica, técnica e artística/cultural
(Scientific, technical and artistical/cultural
production)
Artigos em revistas sem arbitragem científica Papers in periodics without scientific refereeing |
1. |
Pereira, Paulo; Westgard, James O; Encarnação, Pedro; Seghatchian, Jerard. 2015. "Evaluation of the measurement uncertainty in screening immunoassays in blood establishments: Computation of diagnostic accuracy
models ", Transfusion and Apheresis Science 52, 1: 35 - 41. The European Union regulation for blood establishments does not require the evaluation of measurement uncertainty in virology
screening tests, which is required by ISO 15189 guideline following GUM principles. GUM modular approaches have been discussed
by medical laboratories researchers but no consensus has been achieved regarding practical application. Meanwhile, the application
of empirical approaches fulfilling GUM principles has gained support. Blood establishments' screening tests accredited by
ISO 15189 need to select an appropriate model even GUM models are intended uniquely for quantitative examination procedures.
Alternative (to GUM) models focused on probability have been proposed in medical laboratories' diagnostic tests. This article
reviews, discusses and proposes models for diagnostic accuracy in blood establishments' screening tests. The output of these
models is an alternative to VIM's measurement uncertainty concept. Example applications are provided for an anti-HCV test
where calculations were performed using a commercial spreadsheet. The results show that these models satisfy ISO 15189 principles
and that the estimation of clinical sensitivity, clinical specificity, binary results agreement and area under ROC curve area
an alternative to the measurement uncertainty concept.
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2. |
Pereira, Paulo; Westgard, James O; Encarnação, Pedro; Seghatchian, Jerard; Sousa, Gracinda. 2015. "The role of uncertainty regarding the results of screening immunoassays in blood establishments ", Transfusion and Apheresis Science 52, 2: 252 - 2. The risk of uncertain results in infectious agents' tests is recognized in blood establishments, being particularly evident
during the blood donor selection. The current risk-based approaches require risk assessment and "risk-based thinking". Accordingly,
the blood establishment should consider the effect of uncertainty in all the technical decisions taken in a screening laboratory.
Since the post-transfusion safety is one of the blood establishments' goals, the risk of post-transfusion infection should
be evaluated and actions taken to decrease the chance of blood donations validation use false negative results. This article
reviews and discusses the sources of uncertainty of infectious agents' reported results in blood establishments. It describes
a set of sources of uncertainty that should be considered in screening immunoassay's decisions. The infectious agents' uncertainty
concern is critical for reporting reliable results.
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3. |
Pereira, Paulo; Westgard, James O; Encarnação, Pedro; Seghatchian, Jerard; Sousa, Gracinda. 2015. "Scheme for the selection of measurement uncertainty models in blood establishments' screening immunoassays ", Transfusion and Apheresis Science 52, 1: 42 - 47. Blood establishments routinely perform screening immunoassays to assess safety of the blood components. As with any other
screening test, results have an inherent uncertainty. In blood establishments the major concern is the chance of false negatives,
due to its possible impact on patients' health. This article briefly reviews GUM and diagnostic accuracy models for screening
immunoassays, recommending a scheme to support the screening laboratories' staffs on the selection of a model considering
the intended use of the screening results (i.e., post-transfusion safety). The discussion is grounded on a “risk-based thinking¿?,
risk being considered from the donor screening interview to the blood components screening immunoassays. A combination of
GUM and diagnostic accuracy models to evaluate measurement uncertainty in blood establishments is recommended.
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Apresentação oral de trabalho Oral work presentation |
1. |
Pereira, Paulo. Measurement uncertainty in screening immunoassays in blood establishments,2016 (Outra). Thesis submitted to attain the degree of PhD in Biotechnology with specialization in Microbiology. |
Indicadores de produção
(Production indicators)
Visualizações do curriculum [
697
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