Alexandra Gabriel Fraga
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Data da última atualização
»Last update
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29/09/2014 |
Dados pessoais (Personal data)
Nome completo
Full name |
Alexandra Gabriel Fraga |
Nome em citações bibliográficas
Quoting name |
Fraga, Alexandra Gabriel |
Categoria profissional
Position |
Investigador Auxiliar |
Domínio científico de atuação
Scientific domain |
Ciências Médicas-Medicina Básica. Ciências Naturais-Ciências Biológicas.
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Endereço profissional
Professional address |
Universidade do Minho Escola de Ciências da Saúde Instituto de Investigação em Ciências da Vida e da Saúde (ICVS) Campus de Gualtar Gualtar 4710-057 Braga Portugal Telefone: (+351)253604834 Correio electrónico: afraga@ecsaude.uminho.pt |
Sexo
Gender |
Feminino»Female |
Graus Académicos
(Academic Degrees)
2006-2010 |
Doutoramento Phd |
Ciências da Saúde.
Universidade do Minho,
Portugal.
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1999-2003 |
Licenciatura Licentiate degree |
Biologia Aplicada
(4 anos » years)
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Universidade do Minho,
Portugal.
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Formação complementar ( studies)
2011 |
Pós-Doutoramento Postdoctorate |
Universidade do Minho,
Portugal.
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Vínculos profissionais
(Professional Positions)
Mar/2003-Actual |
Investigador Auxiliar |
Projetos de Investigação (Research projects)
Participação como Investigador Participation as Researcher |
2010-2013 BURULIVAC- Identificação e desenvolvimento de vacinas candidatas para a Úlcera do Buruli-BuruliVac-Identification and development of vaccine candidates for Buruli Ulcer disease |
Referência do projeto»Project reference: 241500. Seventh Framework Project
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2006-2009 Role of Interleukin-23 (IL-23) and IL-17 in the regulation of the immune response to the infection by Mycobacterium tuberculosis
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Referência do projeto»Project reference: PTDC/SAU-MII/70895/2006. FCT
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2006-2009 Úlcera do Buruli - Da compreensão dos mecanismos de resistência do hospedeiro ao desenvolvimento de novas intervenções contra
uma micobacteriose emergente- Buruli Ulcer – understanding of the mechanisms of host resistance and development of new interventions against an emergent
mycobacteriosis
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Referência do projeto»Project reference: Fundação Calouste Gulbenkian.
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2003-2005 Impacto em saúde pública de micobacterioses de difícil tratamento: tuberculose multi-resistente e úlcera do Buruli-Impact of difficult-to-treat mycobacterioses in public health: multi-drug resistant Tuberculosis and Buruli ulcer |
Referência do projeto»Project reference: Fundação Calouste Gulbenkian.
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Línguas (Languages)
Compreende Understandig |
Português (Bem), Inglês (Bem). |
Fala Speaking |
Português (Bem), Inglês (Bem). |
Lê Reading |
Português (Bem), Inglês (Bem). |
Escreve Writing |
Português (Bem), Inglês (Bem). |
Prémios e títulos (Awards Prizes, and Honours)
2006 |
Best Poster at II Simpósio Nacional de Citocinas,
Citomed.
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2006 |
Prémio de Excelência em Imunologia Arala Chaves,
Sociedade Portuguesa de Imunologia.
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2010 |
SPI Best Papr Award 2010,
Sociedade Portuguesa de Imunologia.
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2010 |
Prémio Pulido Valente Ciência 2010,
Fundação Francisco Pulido Valente.
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Membro de Associações Profissionais/Científicas (Professional/Scientific Association membership)
Actual |
Sociedade Portuguesa de Imunologia, Membro.
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Produção científica, técnica e artística/cultural
(Scientific, technical and artistical/cultural
production)
Artigos em revistas com arbitragem científica Papers in periodics with scientific refereeing |
1. |
Trigo, Gabriela; Martins, Teresa G; Fraga, Alexandra G; Longatto-Filho, Adhemar; Castro, António G; Azeredo, Joana; Pedrosa, Jorge. 2013. "Phage Therapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad Model", PLoS Neglected Tropical Diseases 7, 4: e2183 - e2183.
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2. |
Martins, Teresa G; Gama, José B; Fraga, Alexandra G; Saraiva, Margarida; Silva, Manuel T; Castro, António G; Pedrosa, Jorge. 2012. "Local and Regional Re-Establishment of Cellular Immunity during Curative Antibiotherapy of Murine Mycobacterium ulcerans Infection", PLoS ONE 7, 2: 32740 - 32740.
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3. |
Fraga, Alexandra G; Martins, Teresa G; Torrado, Egídio; Huygen, Kris; Portaels, Françoise; Silva, Manuel T; Castro, António G; Pedrosa, Jorge. 2012. "Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer following BCG or Mycolactone-Negative Mycobacterium
ulcerans Vaccination", PLoS ONE 7, 3: 33406 - 33406.
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4. |
Martins, Teresa G; Trigo, Gabriela; Fraga, Alexandra G; Gama, José B; Longatto-Filho, Adhemar; Saraiva, Margarida; Silva, Manuel T; Castro, António G; Pedrosa, Jorge. 2012. "Corticosteroid-Induced Immunosuppression Ultimately Does Not Compromise the Efficacy of Antibiotherapy in Murine Mycobacterium
ulcerans Infection", PLoS Neglected Tropical Diseases 6, 11: e1925 - e1925.
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5. |
Fraga, A. G; Cruz, A.; Martins, T. G; Torrado, E.; Saraiva, M.; Pereira, D. R; Meyers, W. M; Portaels, F.; Silva, M. T; Castro, A. G; Pedrosa, J.. 2011. "Mycobacterium ulcerans triggers T cell immunity followed by local and regional but not systemic immunosuppression", Infection and Immunity 79, 1: 421 - 430. |
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6. |
Torrado, E. *; Fraga, A. G. *; Logarinho, E.; Martins, T. G; Carmona, J. A; Gama, J. B; Carvalho, M. A; Proenca, F.; Castro, A. G; Pedrosa, J.. 2010. "IFN-gamma-dependent activation of macrophages during experimental infections by Mycobacterium ulcerans is impaired by the
toxin mycolactone.", J Immunol 184, 2: 947 - 955. * E. Torrado and A. G. Fraga share co-authorship. |
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7. |
Cruz, A.; Fraga, A. G; Fountain, J. J; Rangel-Moreno, J.; Torrado, E.; Saraiva, M.; Pereira, D. R; Randall, T. D; Pedrosa, J.; Cooper, A. M; Castro, A. G. 2010. "Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis.", J Exp Med 207, 8: 1609 - 1616. |
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8. |
Kibadi, K.; Boelaert, M.; Fraga, A. G; Kayinua, M.; Longatto-Filho, A.; Minuku, J. B; Mputu-Yamba, J. B; Muyembe-Tamfum, J. J; Pedrosa, J.; Roux, J. J; Meyers, W. M; Portaels, F.. 2010. "Response to treatment in a prospective cohort of patients with large ulcerated lesions suspected to be Buruli Ulcer (Mycobacterium
ulcerans disease).", PLoS Negl Trop Dis 4, 7: 7361 - 8. |
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9. |
Eddyani, M.; Fraga, A. G; Schmitt, F.; Uwizeye, C.; Fissette, K.; Johnson, C.; Aguiar, J.; Sopoh, G.; Barogui, Y.; Meyers, W. M; Pedrosa, J.; Portaels, F.. 2009. "Fine-needle aspiration, an efficient sampling technique for bacteriological diagnosis of nonulcerative Buruli ulcer.", J Clin Microbiol 47, 6: 1700 - 1704. |
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10. |
Kibadi, K.; Panda, M.; Tamfum, J. J; Fraga, A. G; Longatto Filho, A; Anyo, G.; Pedrosa, J.; Nakazawa, Y.; Suykerbuyk, P.; Meyers, W. M; Portaels, F.. 2008. "New foci of Buruli ulcer, Angola and Democratic Republic of Congo.", Emerg Infect Dis 14, 11: 1790 - 1792. |
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11. |
Gaspar, M. M; Cruz, A.; Fraga, A. G; Castro, A. G; Cruz, M. E; Pedrosa, J.. 2008. "Developments on drug delivery systems for the treatment of mycobacterial infections.", Curr Top Med Chem 8, 7: 579 - 591. |
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12. |
Gaspar, M. M; Cruz, A.; Penha, A. F; Reymao, J.; Sousa, A. C; Eleuterio, C. V; Domingues, S. A; Fraga, A. G; Filho, A. L; Cruz, M. E; Pedrosa, J.. 2008. "Rifabutin encapsulated in liposomes exhibits increased therapeutic activity in a model of disseminated tuberculosis.", Int J Antimicrob Agents 31, 1: 37 - 45. |
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13. |
Portaels, F.; Meyers, W. M; Ablordey, A.; Castro, A. G; Chemlal, K.; de Rijk, P; Elsen, P.; Fissette, K.; Fraga, A. G; Lee, R.; Mahrous, E.; Small, P. L; Stragier, P.; Torrado, E.; Van Aerde, A; Silva, M. T; Pedrosa, J.. 2008. "First cultivation and characterization of Mycobacterium ulcerans from the environment.", PLoS Negl Trop Dis 2, 3: 178 - 178. |
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14. |
Torrado, E.; Adusumilli, S.; Fraga, A. G; Small, P. L; Castro, A. G; Pedrosa, J.. 2007. "Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has
implications for the control of infection.", Infect Immun 75, 8: 3979 - 3988. |
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15. |
Torrado, E.; Fraga, A. G; Castro, A. G; Stragier, P.; Meyers, W. M; Portaels, F.; Silva, M. T; Pedrosa, J.. 2007. "Evidence for an intramacrophage growth phase of Mycobacterium ulcerans.", Infect Immun 75, 2: 977 - 987. |
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16. |
Cruz, A.; Khader, S. A; Torrado, E.; Fraga, A. G; Pearl, J. E; Pedrosa, J.; Cooper, A. M; Castro, A. G. 2006. "Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection.", J Immunol 177, 3: 1416 - 1420. |
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17. |
Oliveira, M. S; Fraga, A. G; Torrado, E.; Castro, A. G; Pereira, J. P; Filho, A. L; Milanezi, F.; Schmitt, F. C; Meyers, W. M; Portaels, F.; Silva, M. T; Pedrosa, J.. 2005. "Infection with Mycobacterium ulcerans induces persistent inflammatory responses in mice.", Infect Immun 73, 10: 6299 - 6310. * M. S. Oliveira and A. G. Fraga share co-authorship. |
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Artigos em revistas sem arbitragem científica Papers in periodics without scientific refereeing |
1. |
Gama, José B; Ohlmeier, Steffen; Martins, Teresa G; Fraga, Alexandra G; Sampaio-Marques, Belém; Carvalho, Maria A; Proença, Fernanda; Silva, Manuel T; Pedrosa, Jorge; Ludovico, Paula. 2014. "Proteomic Analysis of the Action of the Mycobacterium ulcerans Toxin Mycolactone: Targeting Host Cells Cytoskeleton and Collagen", PLoS Neglected Tropical Diseases 8, 8: e3066 - e3066.
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Apresentação oral de trabalho Oral work presentation |
1. |
Fraga, Alexandra G. Genetic determinants of susceptibility - Buruli ulcer and invasive fungi cases,Fundamentals in Immunology and Infection,Braga,2014 (Seminário). |
2. |
Fraga, Alexandra G. Animal model of resistance to experimental Buruli ulcer: characterization of Mycobacterium ulcerans infection in the guinea-pig,Fundamentals in Immunology and Infection,Braga,2013 (Seminário). |
3. |
Fraga, Alexandra G. Experimental Buruli ulcer- understanding host-pathogen interactions,Fundamentals in Immunology and Infection,Braga,2012 (Seminário). |
4. |
Fraga, Alexandra G. Mouse model of Buruli Ulcer: protection conferred by Mycobacterium bovis BCG or with a mycolactone negative strain of M. ulcerans,WHO Annual Meeting on Buruli Ulcer,Geneva,2011 (Conferência ou palestra). |
5. |
Fraga, Alexandra G. Experimental Buruli ulcer: Insight on immunological responses during vaccination and treatment in the mouse model,Buruli Ulcer Symposium,Antwerp,2011 (Comunicação). |
6. |
Fraga, Alexandra G; Cruz, A.; Martins, T. G; Torrado, E.; Saraiva, M.; Pereira, D. R; Meyers, W. M; Portaels, F.; Silva, M. T; Castro, A. G; Pedrosa, J.. The role of adaptive immunity in Mycobacterium ulcerans infection ,Sociedade Portuguesa de Imunologia - International School of Immunology,Tavira,2010 (Comunicação). |
7. |
Fraga, A. G; Braga, J. E; Cruz, A.; Martins, T. G; Ramos-Pereira, D.; Meyers, W. M; Portaels, F.; Castro, A. G; Pedrosa, J.. Failure of the host to generate a protective response against infection with mycolactone-producing Mycobacterium ulcerans
is not associated with an impaired development of a Tcell-mediated response in the draining lymph node.,European Society of Mycobacteriology ,Porto,2009 (Congresso). |
8. |
Torrado, E.; Fraga, A. G; Logarinho, E.; Carmona, J. A; Gama, J. B; Carvalho, M. A; Proenca, F.; Castro, A. G; Pedrosa, J.. The protective IFN-gamma-dependent activation of macrophages induced during infection with Mycobacterium ulcerans is impaired
by the exotoxin mycolactone,Microbiotec,Vila Moura,2009 (Congresso). |
9. |
Fraga, A. G; Torrado, E.; Campos, S. A; Castro, A. G; Pedrosa, J.. Infection with virulent Mycobacterium ulcerans compromises the development of an immune response in the draining lymph nodes
,Congresso da Sociedade Portuguesa de Microscopia,Coimbra,2007 (Congresso). |
Outra produção técnica Other technical production |
1. |
Fraga, Alexandra G. Susceptibility to Buruli Ulcer: multiple immune-genetic polymorphism dissection through a Benin (Africa) population case-control
study,2013. |
2. |
Fraga, Alexandra G. Animal model of resistance to experimental Buruli ulcer: characterization of Mycobacterium ulcerans infection in the guinea-pig,2012. |
3. |
Fraga, Alexandra G; Martins, T. G; Torrado, E.; Portaels, F.; Silva, M. T; Castro, A. G; Pedrosa, J.. Cellular immunity confers transient protection in experimental Buruli ulcer following BCG or mycolactone-negative Mycobacterium
ulcerans vaccination ,2011. |
4. |
Fraga, Alexandra G; Cruz, A.; Martins, T. G; Torrado, E.; Saraiva, M.; Pereira, D. R; Meyers, W. M; Portaels, F.; Silva, M. T; Castro, A. G; Pedrosa, J.. The role of adaptive immunity in Mycobacterium ulcerans infection ,2010. |
5. |
Torrado, E.; Fraga, A. G; Logarinho, E.; Martins, T. G; Carmona, J. A; Gama, J. B; Carvalho, M. A; Proenca, F.; Castro, A. G; Pedrosa, J.. Mycolactone interferes with the protective IFN-gamma-dependent activation of macrophages during infection with Mycobacterium
ulcerans ,2009. |
6. |
Fraga, A. G; Braga, J. E; Cruz, A.; Martins, T. G; Pereira, D. R; Portaels, F.; Castro, A. G; Pedrosa, J.. Failure to generate a protective response against M. ulcerans is not associated with an impaired development of specific T
cells in the draining lymph node. ,2009. |
7. |
Cruz, A.; Fraga, A. G; Pereira, D. R; Saraiva, A. L; Saraiva, M.; Correia-Neves, M.; Cooper, A. M; Pedrosa, J.; Castro, A. G. Control of Mycobacterium tuberculosis infection depends on the time of previous exposure to BCG vaccination,2009. |
8. |
Fraga, A. G; Torrado, E.; Braga, J. E; Castro, A. G; Pedrosa, J.. Mycobacterium ulcerans induces massive apoptosis in the draining lymph node of infected mice ,2008. |
9. |
Fraga, A. G; Torrado, E.; Campos, S. A; Castro, A. G; Pedrosa, J.. Lymph node dynamics during experimental infection by Mycobacterium ulcerans.,2007. |
10. |
Fraga, A. G; Torrado, E.; Castro, A. G; Pedrosa, J.. IFN-gamma induces LRG47 and nitric oxide in macrophages, playing a protective role following infection by a mycolactone-negative
strain of Mycobacterium ulcerans,2006. |
11. |
Cruz, A.; Khader, S. A; Torrado, E.; Fraga, A. G; Pearl, J. E; Pedrosa, J.; Cooper, A. M; Castro, A. G. IL-17-producing CD4 T cells induced during mycobacterial infection are regulated by IFN-gamma,2006. |
12. |
Cruz, A.; Fraga, A. G; Torrado, E.; Cooper, A. M; Pedrosa, J.; Castro, A. G. Th17 cells inducing a massive recruitment of neutrophils may play a role in Koch´s reaction,2006. |
13. |
Fraga, A. G; Torrado, E.; Castro, A. G; Pedrosa, J.. IFN-gamma by inducing LRG-47 and Nitric Oxide plays a protective role following infection by low virulent strains of Mycobacterium
ulcerans,2006. |
14. |
Torrado, E.; Fraga, A. G; Castro, A. G; Pedrosa, J.. TNF plays a protective role in infections by low virulent strains of Mycobacterium ulcerans,2006. |
15. |
Torrado, E.; Fraga, A. G; Castro, A. G; Silva, M. T; Pedrosa, J.. Intramacrophage growth of Mycobacterium ulcerans,2006. |
16. |
Torrado, E.; Fraga, A. G; Castro, A. G; Silva, M. T; Pedrosa, J.. Mycobacterium ulcerans growth within murine macrophages,2006. |
17. |
Torrado, E.; Fraga, A. G; Castro, A. G; Silva, M. T; Pedrosa, J.. TNF plays a protective role in infections by low virulent strains of Mycobacterium ulcerans,2006. |
18. |
Cruz, A.; Khader, S. A; Torrado, E.; Fraga, A. G; Pearl, J. E; Pedrosa, J.; Cooper, A. M; Castro, A. G. IFN-gamma limits the accumulation of CD4 , antigen specific, IL-17 producing T cells,2006. |
19. |
Oliveira, M. S; Fraga, A. G; Milanezi, F.; Schmitt, F. C; Portaels, F.; Silva, M. T; Castro, A. G; Pedrosa, J.. Study of the virulence of different Mycobacterium ulcerans strains in the footpad mouse model and characterization of the
respective host inflammatory responses. ,2004. |
20. |
Oliveira, M. S; Fraga, A. G; Silva, M. T; Castro, A. G; Pedrosa, J.. Characterization of the virulence and pathology induced by different Mycobacterium ulcerans strains in the footpad mouse model.,2003. |
Dados Complementares (Additional data)
Dissertação de Mestrado Master degree dissertation |
1. |
Ana Rita de Araújo e Silva Gomes, The impact of immune gene polymorphisms in human Mycobacterium ulcerans infection, 2014. Dissertação (Ciências da Saúde) - Universidade do Minho (Orientador). |
Trabalho de conclusão de curso de Bacharelato/Licenciatura Bachelor/Licenciate degree conclusion work |
1. |
Ana Rita de Araújo e Silva Gomes, Úlcera de Buruli: Análise comparativa do modelo murino e do porquinho-da-índia durante a infeção por Mycobacterium ulcerans, 2012. Trabalho de Conclusão de Curso (Licenciatura em Bioquímica) - Universidade do Minho (Orientador). |
Indicadores de produção
(Production indicators)
Visualizações do curriculum [
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